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NLRP1 senses cellular infection by distinct invasive pathogens.
NLRP1 promotes melanoma growth by enhancing inflammasome activation and suppressing apoptotic pathways.
Two new mutations in NLRP1 (c.3641C>G, p.Pro1214Arg and c.2176C>T; p.Arg726Trp) were found to cause a new autoinflammatory syndrome, NLRP1-associated autoinflammation with arthritis and dyskeratosis.
Th17 micro-milieu via IL-17A (show IL17A ELISA Kits) regulates NLRP1-dependent CASP5 (show CASP5 ELISA Kits) activity in psoriatic skin autoinflammation.
HO-1 (show HMOX1 ELISA Kits) inhibited expression of activating transcription factor 4 (ATF4 (show ATF4 ELISA Kits)), which is a transcription factor regulating NLRP1 expression
Simvastatin intake in peripheral arterial disease patients increases in vitro reactivity of NLRP1 inflammasome gene expression in endothelial cells.
these findings establish a group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin (show MEFV ELISA Kits) domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition.
The NLRP3 (show NLRP3 ELISA Kits) and NLRP1 inflammasomes are activated in Alzheimer's disease
NLRP1 inflammasome is activated by extracellular acidosis through ASIC1a (show ACCN2 ELISA Kits) signal pathway.
Nlrp1 inflammasome is downregulated in trauma patients
The findings indicate that NLRP1 inflammasome activation does not significantly contribute to acute neural injury in the murine model of moderate CCI injury.
the aim of this study was to evaluate the effects of chronic dexamethasone (DEX) treatment on nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 1 (NLRP-1) inflammasome in male mice.
NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18 (show IL18 ELISA Kits), preventing obesity and metabolic syndrome.
these data identify NLRP1 as an essential mediator of the host immune response during IBD and cancer.
Data show that eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 (show CASP1 ELISA Kits) activation by the NLR (show CXCR5 ELISA Kits) family leucine-rich repeat protein (show LRRC10 ELISA Kits) (NLRP)1 and NLRP3 (show NLRP3 ELISA Kits) inflammasomes.
The NOD-like receptor NLRP1a/Caspase-1 (show CASP1 ELISA Kits) pathway is the best candidate to mediate the parasite-induced cell death.
Caspase-8 (show CASP8 ELISA Kits) promotes NLRP1/NLRP3 (show NLRP3 ELISA Kits) inflammasome activation and IL-1beta (show IL1B ELISA Kits) production in acute glaucoma.
These findings reveal Toxoplasma gondii as a novel activator of the NLRP1 and NLRP3 (show NLRP3 ELISA Kits) inflammasomes in vivo and establish a role for these sensors in host resistance to toxoplasmosis.
Arsenicals, including arsenic trioxide and sodium arsenite, inhibited activation of the NLRP1, NLRP3 (show NLRP3 ELISA Kits), and NAIP5/NLRC4 (show NLRC4 ELISA Kits) inflammasomes.
the NLRP1 and NLRP3 (show NLRP3 ELISA Kits) inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
NACHT, leucine rich repeat and PYD containing 1
, NLR family protein 1
, NLR family, pyrin domain containing 1
, resistant anthrax lethal toxin
, NACHT, LRR and PYD domains-containing protein 1
, NLR family pyrin domain containing 1
, NACHT, LRR and PYD containing protein 1
, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1
, caspase recruitment domain protein 7
, caspase recruitment domain-containing protein 7
, death effector filament-forming Ced-4-like apoptosis protein
, nucleotide-binding domain and caspase recruitment domain
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
, NACHT/LRR/pyrin domain-containing protein 1
, caspase recruitment domain protein