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C-terminal cytoplasmic fragment of PcdhgC5 (show PCDHGC5 ELISA Kits) acts as a scaffold for CaMKP and CaMKI (show CAMK1 ELISA Kits) to regulate CaMKP activity.
The POPX2 phosphatase regulates cancer cell motility and invasiveness.
The binding of POPX2 (PPM1F) to mDia1 or to an mDia-containing complex greatly decreases the ability of mDia1 to activate transcription from the serum response element (SRE).
This study, combined with our previous findings, suggests that a single ubiquitously expressed phosphatase POPX2 influences cancer metastasis via modulating multiple biological processes including MAPK (show MAPK1 ELISA Kits) signaling and exosome cytokine secretion.
Overexpression of PPM1F is associated with metastasis of hepatocellular carcinoma.
POPX2 affects trafficking by determining the phosphorylation status of KIF3A (show KIF3A ELISA Kits) at serine 690.
POPX2 might regulate cell motility through its regulation of the MAPK1 (show MAPK3 ELISA Kits)/3, leading to changes in the cytoskeleton and cell motility.
hCaMKP activity is reversibly regulated by oxidation/reduction at Cys (show DNAJC5 ELISA Kits)-359
FHOD1 (show FHOD1 ELISA Kits) and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR (show MLXIP ELISA Kits)-200c. Expression levels of FHOD1 (show FHOD1 ELISA Kits) and PPM1F were inversely correlated with miR (show MLXIP ELISA Kits)-200c level in breast cancer cell lines and breast cancer patient samples.
Data identify a biochemical pathway through which POPX2 exerts its apparent cellular function: the regulation of activity of glycogen synthase kinase-3 (show GSK3b ELISA Kits), which in turn modulates extracellular signal-regulated kinase and cell motility.
The p21 (show CDKN1A ELISA Kits)-activated kinase PAK is negatively regulated by POPX1 (show PPM1E ELISA Kits) and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (POPX1 (show PPM1E ELISA Kits); POPX2)
PPM1F plays a key role in the regulation of CaMKII (show CAMK2G ELISA Kits) intracellularly
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
ca(2+)/calmodulin-dependent protein kinase phosphatase
, caM-kinase phosphatase
, calcium/calmodulin-dependent protein kinase phosphatase
, partner of PIX2
, protein phosphatase 1F
, Ca(2+)/calmodulin-dependent protein kinase phosphatase
, CaM-kinase phosphatase
, PP2C phosphatase
, partner of PIX 2
, protein fem-2 homolog
, protein phosphatase 1F (PP2C domain containing)