Browse our anti-Prosaposin (PSAP) Antibodies

Full name:
anti-Prosaposin Antibodies (PSAP)
On www.antibodies-online.com are 128 Prosaposin (PSAP) Antibodies from 22 different suppliers available. Additionally we are shipping Prosaposin Kits (32) and Prosaposin Proteins (21) and many more products for this protein. A total of 191 Prosaposin products are currently listed.
Synonyms:
2310034O17Rik, AI037048, AI255158, AU018396, C77849, cb759, GLBA, PSAP, SAP1, Sftp1, Sftpa, Sftpl, SGP-1, SGP1A, SP-A, wu:fa14a06, wu:fb36e02, wu:fb58g07

Most Popular Reactivities for anti-Prosaposin (PSAP) Antibodies

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anti-Mouse (Murine) Prosaposin Antibodies:

anti-Human Prosaposin Antibodies:

anti-Rat (Rattus) Prosaposin Antibodies:

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Top referenced anti-Prosaposin Antibodies

  1. Mouse (Murine) Polyclonal Prosaposin Primary Antibody for IHC, WB - ABIN3022606 : OBrien, Kishimoto: Saposin proteins: structure, function, and role in human lysosomal storage disorders. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991 (PubMed)
    Show all 3 references for 3022606

  2. Human Polyclonal Prosaposin Primary Antibody for EIA, WB - ABIN453360 : Kuchar, Ledvinová, Hrebícek, Mysková, Dvoráková, Berná, Chrastina, Asfaw, Elleder, Petermöller, Mayrhofer, Staudt, Krägeloh-Mann, Paton, Harzer: Prosaposin deficiency and saposin B deficiency (activator-deficient metachromatic leukodystrophy): report on two patients detected by analysis of urinary sphingolipids and carrying novel PSAP gene mutations. in American journal of medical genetics. Part A 2009 (PubMed)
    Show all 2 references for 453360

  3. Human Monoclonal Prosaposin Primary Antibody for ICC, FACS - ABIN1098150 : Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. in The Biochemical journal 2011 (PubMed)
    Show all 2 references for 1098150

  4. Human Monoclonal Prosaposin Primary Antibody for IHC (p), IP - ABIN562465 : Koochekpour, Hu, Vellasco-Gonzalez, Bernardo, Azabdaftari, Zhu, Zhau, Chung, Vessella: Serum prosaposin levels are increased in patients with advanced prostate cancer. in The Prostate 2012 (PubMed)

  5. Human Polyclonal Prosaposin Primary Antibody for ELISA, WB - ABIN1535203 : Rorman, Grabowski: Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats. in Genomics 1990 (PubMed)

More Antibodies against Prosaposin Interaction Partners

Zebrafish Prosaposin (PSAP) interaction partners

Mouse (Murine) Prosaposin (PSAP) interaction partners

  1. Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB (show PC Antibodies) exposure.

  2. Prosaposin facilitates sortilin (show SORT1 Antibodies)-independent lysosomal trafficking of progranulin (show GRN Antibodies).

  3. Mesotrypsin (show PRSS3 Antibodies) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Antibodies) contributed to this process by activating mesotrypsinogen (show PRSS3 Antibodies) to mesotrypsin (show PRSS3 Antibodies). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  4. Low levels of prosaposin and its receptors in the mouse brain suggest the participation of prosaponin in pathological changes in the brains of dystrophic mdx (show DMD Antibodies) mice.

  5. These data show functional association between GPR37, prosaposin, and GM1 ganglioside in the plasma membrane.

  6. Prosaposin is involved in the regulation of muscle differentiation of regenerated fibres

  7. Saposins A and B deficiencies attenuated GalCer-beta-galactosylceramidase (show GALC Antibodies) and GM1-beta-galactosidase (show GLB1 Antibodies) functions in the degradation of lactosylceramide in the liver.

  8. These data suggest that prosaposin plays an important role in the neuronal maturation processes of the vestibular sensory epithelium and the maintenance of normal vestibular system function.

  9. The saposin C deficient mice backcrossed to point mutated GCase (show GBA Antibodies) mimics the central nervous system phenotype and biochemistry of some type 3 (neuronopathic) variants of Gaucher disease.

  10. UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin.

Human Prosaposin (PSAP) interaction partners

  1. This report documents the successful use of plasma lysoSLs profiling in the PSAP deficiency diagnosis, as a reliable and informative tool to obtain a preliminary information in infantile cases with complex traits displaying severe neurological signs and visceral involvement.

  2. an extensive review of all the PSAP-causative variants published in the literature to date, accounting for a total of 10 PSAP allele types (review)

  3. Our findings suggest a novel pharmacological approach to Sap (show APCS Antibodies) C deficiency directed to treat major secondary pathological aspects in this disorder.

  4. PSAP is a secreted biomarker.

  5. Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB (show PC Antibodies) exposure.

  6. Prosaposin facilitates sortilin (show SORT1 Antibodies)-independent lysosomal trafficking of progranulin (show GRN Antibodies).

  7. findings support a lung metastasis-promoting function of the miR (show MLXIP Antibodies)-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer

  8. Mesotrypsin (show PRSS3 Antibodies) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Antibodies) contributed to this process by activating mesotrypsinogen (show PRSS3 Antibodies) to mesotrypsin (show PRSS3 Antibodies). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  9. Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z (show CTSZ Antibodies) and cathepsin H (show CTSH Antibodies).

  10. Saposin C protects glucocerebrosidase (show GBA Antibodies) against alpha-synuclein (show SNCA Antibodies) inhibition.

Pig (Porcine) Prosaposin (PSAP) interaction partners

  1. identified 68 single-nucleotide polymorphisms and 9 indels in the pig PASP (show CPB1 Antibodies) gene, and three single-nucleotide polymorphisms were nonsynonymous substitutions

  2. Saposin B (Sap (show APCS Antibodies) B) is not a limiting factor of the coupled Sap (show APCS Antibodies) B-arylsulfatase A (show ARSA Antibodies) reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels.

Prosaposin (PSAP) Antigen Profile

Antigen Summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with Prosaposin (PSAP)

  • prosaposin (psap) antibody
  • prosaposin (PSAP) antibody
  • prosaposin (LOC100304726) antibody
  • prosaposin (LOC100526719) antibody
  • mitochondrial carrier homolog 1 (C. elegans) (Mtch1) antibody
  • prosaposin (Psap) antibody
  • prosaposin (LOC100359322) antibody
  • surfactant protein A1 (Sftpa1) antibody
  • 2310034O17Rik antibody
  • AI037048 antibody
  • AI255158 antibody
  • AU018396 antibody
  • C77849 antibody
  • cb759 antibody
  • GLBA antibody
  • PSAP antibody
  • SAP1 antibody
  • Sftp1 antibody
  • Sftpa antibody
  • Sftpl antibody
  • SGP-1 antibody
  • SGP1A antibody
  • SP-A antibody
  • wu:fa14a06 antibody
  • wu:fb36e02 antibody
  • wu:fb58g07 antibody

Protein level used designations for anti-Prosaposin (PSAP) Antibodies

prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) , prosaposin , proactivator polypeptide-like , mitochondrial carrier homolog 1 , mitochondrial carrier-like protein 1 , proactivator polypeptide , sphingolipid activator protein-1 , snoRNA MBII-198 , sulfated glycoprotein 1 , prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator) , PSAP , PSP-A , Surfactant-associated protein 1 (pulmonary surfactant protein SP-A) , Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A) , pulmonary surfactant-associated protein A , surfactant associated protein A , surfactant, pulmonary-associated protein A1

GENE ID SPECIES
140811 Danio rerio
450517 Pan troglodytes
709510 Macaca mulatta
100011417 Monodelphis domestica
100304726 Ictalurus punctatus
100399482 Callithrix jacchus
100526719 Ictalurus punctatus
100593695 Nomascus leucogenys
56462 Mus musculus
5660 Homo sapiens
19156 Mus musculus
25524 Rattus norvegicus
100359322 Oryctolagus cuniculus
100713024 Cavia porcellus
100153167 Sus scrofa
281433 Bos taurus
395602 Gallus gallus
479240 Canis lupus familiaris
100135695 Ovis aries
24773 Rattus norvegicus
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