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Data suggest that Rab35 (show RAB35 Proteins), interacting with TBC1D10A, functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2 (show CA2 Proteins)+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 (show ACAP2 Proteins) and Arf6 (show ARF6 Proteins). (Rab35 (show RAB35 Proteins) = rab (show HRB Proteins) GTP-binding protein 53 (show IGFBP3 Proteins); TBC1D10A = TBC1 domain family member 10A; ACAP2 (show ACAP2 Proteins) = centaurin beta2; Arf6 (show ARF6 Proteins) = ADP-ribosylation factor 6 (show ARF6 Proteins))
EPI64, a candidate GAP that is specific for Rab27 (show RAB27A Proteins).
Data suggest that EPI64A and B, which are ubiquitously expressed members of the EPI64 subfamily, inactivate Ras and certain Rabs at the periphery of cells.
EPI64 regulates membrane trafficking both by stabilizing Arf6 (show ARF6 Proteins)-GTP (show AK3 Proteins) and by inhibiting the recycling of membrane through the tubular endosome by decreasing Rab8a (show RAB8A Proteins)-GTP (show AK3 Proteins) levels.
analysis of recycling of the Ca2 (show CA2 Proteins)+-activated K+ channel (show KCNC4 Proteins), KCa2.3 (show KCNN3 Proteins), is dependent upon RME-1 (show EHD1 Proteins), Rab35 (show RAB35 Proteins)/EPI64C (show TBC1D10C Proteins), and an N-terminal domain
EPI64 is a GTPase-activating protein (show RASA1 Proteins) specific for Rab27A (show RAB27A Proteins)
These data reveal that microvilli have distinct cytoskeletal subdomains and that EPI64 regulates microvillar structure.
EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to immunological synapse formation, most likely by participating in TCR transport to the immunological synapse
Acts as GTPase-activating protein for RAB27A (By similarity).
EBP50-PDX interactor of 64 kDa
, EBP50-PDZ interactor of 64 kD
, TBC1 domain family member 10A