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Data indicate higher ASXL2 expression in ERalpha (show ESR1 ELISA Kits)-positive patients, suggesting that ASXL2 could be a prognostic marker in breast cancer.
Mutation in ASXL2 is associated with core-binding factor (show CBFB ELISA Kits) acute myeloid leukemia (show BCL11A ELISA Kits).
ASXL2 mutation is associated with acute myeloid leukemia (show BCL11A ELISA Kits).
de novo truncating variants in ASXL2 underlie a neurodevelopmental syndrome with a clinically recognizable phenotype; this report expands the germline disorders that are linked to the ASXL genes
inactivation of the BAP1 (show RNF2 ELISA Kits)/ASXL2 axis might contribute to cancer development.
ASXL1, ASXL2 and ASXL3 are epigenetic scaffold proteins that are involved in the pathogenesis of non-cancerous diseases and cancers.[Review]
identify a high-frequency mutation in t(8;21)/RUNX1 (show RUNX1 ELISA Kits)-RUNX1T1 (show RUNX1T1 ELISA Kits) acute myekoid leukemia (AML (show RUNX1 ELISA Kits)) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 mutations in this unique subset of AML (show RUNX1 ELISA Kits)
WTIP interacts (show WTIP ELISA Kits) with ASXL2 and blocks ASXL2-mediated activation of retinoic acid (show WTIP ELISA Kits)signaling.
ASXL1 (show ASXL1 ELISA Kits) represses, whereas ASXL2 increases, the expression of adipogenic genes, most of which are PPARgamma (show PPARG ELISA Kits) targets
ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis
Asxl2-/- neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth.
ASXL2 and WTIP (show WTIP ELISA Kits) are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP (show WTIP ELISA Kits) participate in regulation of retinoic acid signaling during heart development.
ASXL2 and PRC2 interact in the adult heart and co-localize to target promoters.
Chromatin factors like Asxl2 function in the adult heart to regulate cell type- and stage-specific patterns of gene expression.
the knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts.
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003
additional sex combs like 2
, additional sex combs like 2 (Drosophila)
, chimeric MOZ-ASXH2 fusion protein-like
, putative Polycomb group protein ASXL2-like
, additional sex combs-like protein 2
, polycomb group protein ASXH2
, putative Polycomb group protein ASXL2
, polycomb group protein ASXH2 homolog