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Data indicate that LRP6 (show LRP6 Proteins), BCL2L14 (show BCL2L14 Proteins), DUSP16 (show DUSP16 Proteins), CREBL2, and CDKN1B (show CDKN1B Proteins) were involed in centromeric (12p11.21-12p13.2) deletion in ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins) B-cell precursor acute lymphoblastic leukemia (BCP (show OPN1SW Proteins)-ALL).
Results of the present study indicate that CREBL2 plays a critical role in adipogenesis and lipogenesis via interaction with CREB (show CREB1 Proteins).
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
cAMP responsive element binding protein-like 2
, MHBs-binding protein 1
, cAMP-responsive element-binding protein-like 2