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Dpr1 promotes the ubiquitination of Dvl2 (show DVL2 ELISA Kits) by pVHL (show VHL ELISA Kits) and mediates the protein aggregate-elicited autophagy initiation
Expression analysis of Dact1-LacZ (show GLB1 ELISA Kits) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.
These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (show DVL1 ELISA Kits) and possibly Disrupted in Schizophrenia-1 (show DISC1 ELISA Kits), in the formation of synapses on cortical interneuron dendrites.
Depletion of Dapper-1 and dishevelled-2 (show DVL2 ELISA Kits) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (show DVL2 ELISA Kits) and that activity of both Dapper-1 and dishevelled-2 (show DVL2 ELISA Kits) is essential for activating canonical Wnt (show WNT2 ELISA Kits) signaling.
conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (show DVL1 ELISA Kits).
Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (show DVL2 ELISA Kits) activity and leads to posterior malformation in mice.
This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (show AKT1 ELISA Kits)
Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis
Dact1 is detected in the presomitic mesoderm and somites during segmentation, in the limb bud mesenchyme and other mesoderm-derived tissues, and in the central nervous system
frd1 is expressed in the developing brain and mesoderm.
two Dvl (show DVL2 ELISA Kits)-associated paralogs, Dpr1 and Dpr2, participate in distinct Wnt (show WNT2 ELISA Kits)-dependent developmental processes
target of beta-catenin (show CTNNB1 ELISA Kits) and/or an unknown downstream effector in development
An inhibitory role for DACT1 in leukemogenesis.
Dact1 is up-regulated by TGF-beta1 (show TGFB1 ELISA Kits), inducing apoptosis in mesangial cells.
The simultaneous methylation of DACT1 and DACT2 may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (show WNT2 ELISA Kits)/beta catenin (show CTNNB1 ELISA Kits) signaling.
our results suggested that DACT1 was upregulated during human placenta development.
There was no statistical difference between groups concerning DACT1 and DACT2 either in promoter hypermethylation or transcript levels. Age was associated with DACT2 promoter hypermethylation, especially over 56 years old.
Overexpression of Dapper-1 allows the translocation of MIZ-1 (show ZBTB17 ELISA Kits) from the nucleus to the cytoplasm.
Dpr1 directly interacts with Beclin1 (show BECN1 ELISA Kits) and Atg14L and enhances the Beclin1 (show BECN1 ELISA Kits)-Vps34 (show PIK3C3 ELISA Kits) interaction and Vps34 (show PIK3C3 ELISA Kits) activity.
Data indicate that Sestd1 cooperates with Dact1 in Vangl2 (show VANGL2 ELISA Kits) regulation and in the planar cell polarity (PCP (show PRCP ELISA Kits)) pathway during mammalian embryonic development.
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
, dapper 1
, dapper, antagonist of beta-catenin
, dapper, antagonist of beta-catenin, homolog 1
, dapper homolog 1-like
, dapper antagonist of catenin 1
, dapper homolog 1
, frodo homolog
, thymus expressed gene 3
, thymus-expressed novel gene 3 protein
, dishevelled-interacting protein
, frodo 1
, hepatocellular carcinoma novel gene 3 protein
, heptacellular carcinoma novel gene 3
, dapper 1-B
, dapper homolog 1, antagonist of beta-catenin