Browse our anti-CD74 (CD74) Antibodies

Full name:
anti-HLA-DR-gamma Antibodies (CD74)
On www.antibodies-online.com are 484 HLA-DR-gamma (CD74) Antibodies from 26 different suppliers available. Additionally we are shipping CD74 Proteins (16) and CD74 Kits (14) and many more products for this protein. A total of 526 CD74 products are currently listed.
Synonyms:
CLIP, DHLAG, HLADG, Ia-GAMMA, II, INVG34

Most Popular Reactivities for anti-CD74 (CD74) Antibodies

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anti-Mouse (Murine) CD74 Antibodies:

anti-Human CD74 Antibodies:

anti-Rat (Rattus) CD74 Antibodies:

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Top referenced anti-CD74 Antibodies

  1. Human Monoclonal CD74 Primary Antibody for ICC, FACS - ABIN361789 : Barrera, Beswick, Sierra, Bland, Espejo, Mifflin, Adegboyega, Crowe, Ernst, Reyes: Polarized expression of CD74 by gastric epithelial cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005 (PubMed)
    Show all 8 references for 361789

  2. Human Monoclonal CD74 Primary Antibody for FACS - ABIN2662681 : Beswick, Pinchuk, Minch, Suarez, Sierra, Yamaoka, Reyes: The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production. in Infection and immunity 2006 (PubMed)
    Show all 5 references for 2662681

  3. Human Monoclonal CD74 Primary Antibody for CyTOF, FACS - ABIN151486 : Lamb, Cresswell: Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes. in Journal of immunology (Baltimore, Md. : 1950) 1992 (PubMed)
    Show all 4 references for 151486

  4. Human Polyclonal CD74 Primary Antibody for IHC (p), IHC - ABIN443052 : Ishihara, Kariya, Okano, Zhao, Maeda, Nishizaki: Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media. in Acta oto-laryngologica 2016 (PubMed)
    Show all 3 references for 443052

  5. Human Monoclonal CD74 Primary Antibody for ICC, FACS - ABIN1724871 : Tian, Zhang, Li, Liu, Dong: CD74: a potential novel target for triple-negative breast cancer. in Tumour biology 2012 (PubMed)
    Show all 2 references for 1724871

  6. Human Monoclonal CD74 Primary Antibody for FACS, ELISA - ABIN1724870 : Zheng, Yang, Rong, Yuan, Ma, Wang, Shen, Cui: CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. in World journal of gastroenterology : WJG 2012 (PubMed)
    Show all 2 references for 1724870

  7. Human Monoclonal CD74 Primary Antibody for ICC, FACS - ABIN2481706 : Denzin, Robbins, Carboy-Newcomb, Cresswell: Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. in Immunity 1995 (PubMed)

More Antibodies against CD74 Interaction Partners

Mouse (Murine) HLA-DR-gamma (CD74) interaction partners

  1. We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a (show SPPL2A Antibodies)(-/-) mice, further supporting a CD74-intrinsic effect.

  2. MIF (show MIF Antibodies)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA Antibodies) secretion in microglia through phosphorylation of microglial ERK1/2 (show MAPK1/3 Antibodies) (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show MIF Antibodies) signaling or its receptor CD74 promotes IFN-gamma (show IFNG Antibodies) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.

  3. CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction.

  4. explored CD74 expression, which can form a complex with CD44 (show CD44 Antibodies), in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis

  5. Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Antibodies) chemokine (show CCL1 Antibodies) expression by modulation of CD74 antigen processing.

  6. Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.

  7. CD74 plays a critical role in the MIF (show MIF Antibodies) inhibition of osteoclastogenesis.

  8. Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.

  9. SPPL2a (show SPPL2A Antibodies)-mediated processing of CD74 NTF (show TNF Antibodies) is indispensable to maintain appropriate levels of tonic BCR (show BCR Antibodies) signaling to promote B cell maturation (show TNFRSF17 Antibodies).

  10. Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74

Human HLA-DR-gamma (CD74) interaction partners

  1. these observations are consistent with the view that CD74 expression in tumor cells promotes the intratumoral immune response and is associated with a better prognosis in basal-like breast cancer

  2. MIF (show AMH Antibodies)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA Antibodies) secretion in microglia through phosphorylation of microglial ERK1/2 (show MAPK1/3 Antibodies) (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show AMH Antibodies) signaling or its receptor CD74 promotes IFN-gamma (show IFNG Antibodies) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.

  3. High CD74 expression is associated with colorectal cancer.

  4. the roles of CD74 and MIF (show AMH Antibodies) in the immune surveillance escape process

  5. CD74 downregulation in placental macrophages is present in preeclampsia.

  6. CD74 was increased in burn patients.

  7. predicted binding of one CD74 trimer to a single RTL1000 antagonist utilized the same two 5 residue determinants

  8. an inverse correlation with the tumor size for stromal MIF (show AMH Antibodies) and a positive correlation with the triple receptor negative tumor status for stromal CD74 seem to be showed

  9. Studies indicate that the invariant chain (CD74) is critical for antigen presentation.

  10. FOXP1 (show FOXP1 Antibodies) represents a novel regulator of genes targeted by the class II MHC (show HLAE Antibodies) transactivator CIITA (show CIITA Antibodies) and CD74.

CD74 Antigen Profile

Antigen Summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with CD74

  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74) antibody
  • CD74 molecule, major histocompatibility complex, class II invariant chain (CD74) antibody
  • Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74) antibody
  • CLIP antibody
  • DHLAG antibody
  • HLADG antibody
  • Ia-GAMMA antibody
  • II antibody
  • INVG34 antibody

Protein level used designations for anti-HLA-DR-gamma (CD74) Antibodies

H-2 class II histocompatibility antigen gamma chain , HLA-DR-GAMMA , Ia-associated invariant chain , MHC class II-associated invariant chain , class II-associated invariant chain peptide , dinucleotide microsatellite , histocompatibility: class II antigens, gamma chain of , ia antigen-associated invariant chain , invariant polypeptide of major histocompatibility complex, class II antigen-associated , CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) , HLA class II histocompatibility antigen gamma chain , HLA-DR antigens-associated invariant chain , HLA-DR-gamma , MHC HLA-DR gamma chain , gamma chain of class II antigens , p33 , ii

GENE ID SPECIES
16149 Mus musculus
972 Homo sapiens
25599 Rattus norvegicus
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