Browse our CD74 Proteins (CD74)

Full name:
HLA-DR-gamma Proteins (CD74)
On www.antibodies-online.com are 16 HLA-DR-gamma (CD74) Proteins from 8 different suppliers available. Additionally we are shipping CD74 Antibodies (444) and CD74 Kits (12) and many more products for this protein. A total of 484 CD74 products are currently listed.
Synonyms:
CLIP, DHLAG, HLADG, Ia-GAMMA, II, INVG34
list all proteins Gene Name GeneID UniProt
CD74 16149 P04441
CD74 972 P04233
Rat CD74 CD74 25599 P10247

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CD74 Proteins (CD74) by Origin

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Top referenced CD74 Proteins

  1. Human CD74 Protein expressed in Human Cells - ABIN2003968 : Henne, Schwenk, Koch, Möller: Surface expression of the invariant chain (CD74) is independent of concomitant expression of major histocompatibility complex class II antigens. in Immunology 1995 (PubMed)
    Show all 5 references for 2003968

  2. Human CD74 Protein expressed in HEK-293 Cells - ABIN2180835 : Scanlon: The evolution of surgical oncology. Presidential address: James Ewing society, New Orleans, 1975. in Cancer 1976 (PubMed)
    Show all 3 references for 2180835

  3. Human CD74 Protein expressed in Wheat germ - ABIN1348699 : Baerlecken, Nothdorft, Stummvoll, Sieper, Rudwaleit, Reuter, Matthias, Schmidt, Witte: Autoantibodies against CD74 in spondyloarthritis. in Annals of the rheumatic diseases 2014 (PubMed)

More Proteins for CD74 Interaction Partners

Mouse (Murine) HLA-DR-gamma (CD74) interaction partners

  1. MIF (show MIF Proteins)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA Proteins) secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show MIF Proteins) signaling or its receptor CD74 promotes IFN-gamma (show IFNG Proteins) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.

  2. CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction.

  3. explored CD74 expression, which can form a complex with CD44 (show CD44 Proteins), in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis

  4. Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Proteins) chemokine (show CCL1 Proteins) expression by modulation of CD74 antigen processing.

  5. Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.

  6. CD74 plays a critical role in the MIF (show MIF Proteins) inhibition of osteoclastogenesis.

  7. Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.

  8. SPPL2a (show SPPL2A Proteins)-mediated processing of CD74 NTF (show TNF Proteins) is indispensable to maintain appropriate levels of tonic BCR (show BCR Proteins) signaling to promote B cell maturation (show TNFRSF17 Proteins).

  9. Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74

  10. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina.

Human HLA-DR-gamma (CD74) interaction partners

  1. MIF (show AMH Proteins)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA Proteins) secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show AMH Proteins) signaling or its receptor CD74 promotes IFN-gamma (show IFNG Proteins) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.

  2. High CD74 expression is associated with colorectal cancer.

  3. the roles of CD74 and MIF (show AMH Proteins) in the immune surveillance escape process

  4. CD74 downregulation in placental macrophages is present in preeclampsia.

  5. CD74 was increased in burn patients.

  6. predicted binding of one CD74 trimer to a single RTL1000 antagonist utilized the same two 5 residue determinants

  7. an inverse correlation with the tumor size for stromal MIF (show AMH Proteins) and a positive correlation with the triple receptor negative tumor status for stromal CD74 seem to be showed

  8. Studies indicate that the invariant chain (CD74) is critical for antigen presentation.

  9. FOXP1 (show FOXP1 Proteins) represents a novel regulator of genes targeted by the class II MHC (show HLAE Proteins) transactivator CIITA (show CIITA Proteins) and CD74.

  10. Interferon gamma (show IFNG Proteins) promotes melanoma cell survival regulating CD74-MIF (show AMH Proteins) interaction.

CD74 Protein Profile

Protein Summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with CD74

  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74)
  • CD74 molecule, major histocompatibility complex, class II invariant chain (CD74)
  • Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74)
  • CLIP protein
  • DHLAG protein
  • HLADG protein
  • Ia-GAMMA protein
  • II protein
  • INVG34 protein

Protein level used designations for HLA-DR-gamma Proteins (CD74)

H-2 class II histocompatibility antigen gamma chain , HLA-DR-GAMMA , Ia-associated invariant chain , MHC class II-associated invariant chain , class II-associated invariant chain peptide , dinucleotide microsatellite , histocompatibility: class II antigens, gamma chain of , ia antigen-associated invariant chain , invariant polypeptide of major histocompatibility complex, class II antigen-associated , CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) , HLA class II histocompatibility antigen gamma chain , HLA-DR antigens-associated invariant chain , HLA-DR-gamma , MHC HLA-DR gamma chain , gamma chain of class II antigens , p33 , ii

GENE ID SPECIES
16149 Mus musculus
972 Homo sapiens
25599 Rattus norvegicus
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