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Hlx1 selectively marks sprouting endothelial cells during zebrafish development.Hlx1 is required for intersegmental vessel angiogenesis in zebrafish embryos.Hlx1 cell-autonomously maintains endothelial stalk cell potential.
HLX1 is significantly downregulated in HCC (show FAM126A Proteins) and suggests that HLX1 has suppressive effects on HCC (show FAM126A Proteins) growth and metastasis. Accordingly, HLX1 may act as a tumor suppressor in HCC (show FAM126A Proteins).
Studies have identified HLX as a novel key transcription factor involved in the regulation of early hematopoiesis and AML (show RUNX1 Proteins) pathogenesis.
The expression levels of Hlx, T-bet, and IFN-gamma (show IFNG Proteins) were significantly decreased.
Data suggest that HLX1 is downstream mediator of hepatocyte growth factor- (HGF (show HGF Proteins)-) induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF (show HGF Proteins) and HLX1 appear to be involved in normal placental development.
This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia (show BCL11A Proteins).
This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth.
a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease.
These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B (show UNC5B Proteins) and to down-modulate sprouting under normoxic conditions.
HLX is a mediator of HGF/c-met-dependent trophoblast migration but is not involved in the regulation of trophoblast invsion.
Cell cycle regulatory genes RB1 (show RB1 Proteins), MYC (show MYC Proteins), CCNB1 (show CCNB1 Proteins), ELK1 (show ELK1 Proteins), JUN (show JUN Proteins), and CDKN1C (show CDKN1C Proteins), which control important trophoblast cell functions, are targets of HLX.
methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Proteins)), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx.
Hlx regulates sprouting in vitro, but its role in sprouting is nonessential in vivo. HLX is regulated by shear stress and a subtle defect in vascular remodeling is present in knockout embryos.
Results shown that over-expressed Hlx in DC2.4 up-regulated the transcription and expression of IFN-gamma, increased the expression of maturation makers including CD40, CD80, CD86, MHC-I and MHC-II
Transient over-expression of Hlx in DC2.4 promotes DC2.4 maturation and up-regulates IL-12 (show IL12A Proteins), IL-10 (show IL10 Proteins) and TGF-beta (show TGFB1 Proteins) expression. H1x (show H1FX Proteins) modified DC2.4 cells seem to function as regulatory dendritic cells
Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma (show IFNG Proteins)
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
, H2.0-like homeobox protein
, H2.0-like homeo box 1
, H2.0-like homeo box-1
, H2.0-like homeobox 1
, homeobox protein HB24
, homeobox protein HLX1