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High CCK2R expression is associated with cancer.
These results suggest that Z-360 exerts an anti-tumor effect through a reduction in anti-apoptosis factors by blocking CCK2R
High CCK-BR expression is associated with Gastric Cancer.
There is no identifiable link between nuclear CCK2R expression and all the clinicopathological characteristics examined in a cohort of Taiwanese colon cancer patients.
Our study showed significantly higher expression of CCKAR and down regulation of CCKBR in pancreatic cancer as compared to control while CCKBR/GR was detected in majority of stomach cancer samples. Thus, our study suggests that CCK (show CCK Proteins) and Gs receptors may have diagnostic and therapeutic implications.
Data indicate that variant c.811+32C>A in cholecystokinin-B receptor gene (CCKBR) does not have a significant impact on pancreatic cancer risk or survival in a Hungarian cohort.
The neurotransmitter cholecystokinin (CCK (show CCK Proteins)), along with its receptors, CCKAR and CCKBR, have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort
There is functional synergy between cholecystokinin (show CCK Proteins) receptors CCKAR and CCKBR in mammalian brain development.
CCK-BR SNP predicts survival and should be studied as a candidate genetic biomarker for those at risk of pancreatic cancer.
treatment with gastrin (show GAST Proteins), a CCK2R agonist, stimulated the secretion of GLP-1 (show GCG Proteins), and that this effect was likely due to increased expression of proglucagon (show GCG Proteins) and PCSK1 (show PCSK1 Proteins) (also known as prohormone convertase 3 (PC3 (show PCSK1 Proteins) gene)).
CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake
findings provide novel evidence that Cnr1 (show CNR1 Proteins) contributes to cued fear expression via an interaction with the CCKB receptor.
mice lacking CCK (show CCK Proteins) receptors exhibited a functional shift from the gastrin (show GAST Proteins)-CCK (show CCK Proteins) pathways to the neuronal pathway in control of the ECL (show APOC4 Proteins) cells and eventually the acid secretion
CCK2R labels +4 antral stem cells that can be activated and expanded by progastrin, thus identifying one hormonal trigger for gastric stem cell interconversion and a potential target for gastric cancer chemoprevention and therapy.
CCK-1 (show CCL28 Proteins) and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 (show CCL28 Proteins) receptors may facilitate CCK (show CCK Proteins)-2 receptor signaling.
cholecystokinin receptor-2 has a role in stress-triggered fear memory and anxiety in the mouse
shift of breakpoint on Arrhenius plot established in CCK (show CCK Proteins)(2) receptor-deficiency confirms that such kind of alteration in Na(+),K(+)-ATPase (show ATP1A1 Proteins) temperature dependence is likely related to the homeostatic adjustment of altered function of the sodium pump.
Environmental enrichment has beneficial effects in neuropathic conditions and reinforce the causal link between CCK(2) receptors, mechanical sensitivity and the development of CCI-induced hypersensitivity.
The gastrin receptor promotes pancreatic growth in transgenic mice.
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
cholecystokinin B receptor
, gastrin/cholecystokinin type B receptor
, CCK-B receptor
, CCK2 receptor
, cholecystokinin-2 receptor
, gastrin receptor
, CCK(B) receptor
, CCK-B/gastrin receptor
, CCK2/gastrin receptor
, Cholecystokinin-2 receptor
, gastrin/CCK-B receptor
, cholecystokinin receptor