Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Study reports that p27 normally exerts a negative feedback on p21 (show D4S234E Antibodies) expression: p27 directly represses the expression of the transcription factor Pitx2 (show PITX2 Antibodies) which in turn maintains decreased p21 (show D4S234E Antibodies) levels. Consequently, in cells lacking p27, de-repression of Pitx2 (show PITX2 Antibodies) causes the up-regulation of p21 (show D4S234E Antibodies) showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (show PITX2 Antibodies) and p21 (show D4S234E Antibodies).
Fbxo7 (show FBXO7 Antibodies)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (show CDK6 Antibodies) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Antibodies) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (show PGR Antibodies)-E2F (show E2F1 Antibodies) and p27-CDK (show CDK4 Antibodies) regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53 (show TP53 Antibodies), promotes ovarian tumor development from the benign adenomas of germ cell-deficient (show FANCL Antibodies) ovaries.
p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha (show TNF Antibodies)/nuclear factor-kappa b pathway. T
Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway.
These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1), GATA3 (show GATA3 Antibodies), and POU4F3 (show POU4F3 Antibodies) as additional therapeutic targets for ATOH1 (show ATOH1 Antibodies)-mediated auditory hair cells regeneration.
Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR (show MLXIP Antibodies)-24 and targeted by the transcription factors FOXO4 (show FOXO4 Antibodies) and AP4 (show REPIN1 Antibodies) in the peroxidasin (Pxdn (show PXDN Antibodies)) mutation-induced eye disorders, such as glaucoma.
These results suggest that fad24 (show NOC3L Antibodies) may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level
The down-regulation of p27 and the activation of mTOR (show FRAP1 Antibodies) pathway may be involved in miR (show MLXIP Antibodies)-222-induced heart failure and autophagy inhibition.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (By similarity).
Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor p27/Kip1
, cyclin-dependent kinase inhibitor 1B
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, cyclin-dependent kinase inhibitor 1B (p27, Kip1)