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Rat (Rattus) FFAR1 ELISA Kit for Sandwich ELISA - ABIN433309
Wu, Li, Li, Sui, Yang, Dong, Xie, Sun: Inhibition of Advanced Glycation Endproduct Formation by Lotus Seedpod Oligomeric Procyanidins through RAGE-MAPK Signaling and NF-κB Activation in High-Fat-Diet Rats. in Journal of agricultural and food chemistry 2015
It regulates insulin (show INS ELISA Kits) secretion in pancreatic beta-cells. (review)
Data from molecular docking simulations suggest that the binding pocket of GPR40 exhibits binding of free fatty acids (FFA) with chain lengths of C15 or fewer; for FFA with lengths longer than C15, part of alkyl chain extends out of binding pocket.
GPR120 (show O3FAR1 ELISA Kits) negatively and GPR40 positively regulate cellular functions during tumor progression in lung cancer cells.
Increased membrane permeability induced by linoleic acid is mediated by an intracellular signaling pathway activated by GPR40 that leads to an increase in membrane levels of Cx43 (show GJA1 ELISA Kits) phosphorylated at serine 373 via Akt (show AKT1 ELISA Kits).
These data demonstrate that R104 in GPR40 is critically involved in the normal receptor functions. Interestingly, R104P is a registered single-nucleotide polymorphism of GPR40.
Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120 (show O3FAR1 ELISA Kits)/FFA4
results suggest that FFAR1 is the functionally dominant free fatty acid receptor in both human and guinea pig airway smooth muscle.
upregulation of GPR40 expression enhances the mitogenic response to epoxyeicosatrienoic acids
Palmitic acid boosted inflammatory response of microvascular endothelial cells to LPS (show IRF6 ELISA Kits) via GPR40 and nSMase (show SMPD2 ELISA Kits).
knocking down the expression of the regulatory subunit PKAR1alpha, thereby reproducing the effects of IL-1beta (show IL1B ELISA Kits) and PGE (show LIPF ELISA Kits) on VSMCs, we demonstrated the contribution of PKA activity to the observed behavior of VSMCs
Results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain.
Data revealed a weak influence of GPR40 agonist on osteoblast markers expression. Nevertheless, a significant increase in OPG (show TNFSF11 ELISA Kits) expression was observed upon GW9508 treatment that contribute to explain the GPR40-related osteoporosis prevention
In the retinas of Vldlr (show VLDLR ELISA Kits)(-/-) mice with low fatty acid uptake but high circulating lipid levels, we found that Ffar1 suppresses expression of the glucose transporter Glut1 (show SLC2A1 ELISA Kits)
activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin (show POMC ELISA Kits) release via PC2, and regulate the endogenous pain control system
These results suggest that both PPARgamma and GRP40 are required for RSG-induced inhibition of mouse calvaria osteoblast differentiation, which is mediated through GSK3beta-dependent pathway.
GPR40 signaling pathway plays an important suppressive role in spinal nociceptive processing after inflammation or nerve injury
GPR 40/120 double-knockout mice are impaired in post-oral fat sensing.
GPR40/FFAR1 indirectly modulates organ-specific effects of CLAs.
GPR40 functions via both G protein-mediated and beta-arrestin-mediated mechanisms; endogenous and synthetic ligands differentially engage these pathways to promote insulin (show INS ELISA Kits) secretion.
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
free fatty acid receptor 1
, G protein-coupled receptor 40
, G-protein coupled receptor 40
, G protein-coupled receptor GPR40