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Browse our anti-GCK (GCK) Antibodies

Full name:
anti-Glucokinase (Hexokinase 4) Antibodies (GCK)
On www.antibodies-online.com are 107 Glucokinase (Hexokinase 4) (GCK) Antibodies from 18 different suppliers available. Additionally we are shipping GCK Proteins (64) and GCK Kits (37) and many more products for this protein. A total of 222 GCK products are currently listed.
Synonyms:
AI385662, BA4487, BL44, FGQTL3, GCK, gck-A, GK, GLK, Gls006, glucokinase, GLUKA, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, Rab8ip, RNGK2

Most Popular Reactivities for anti-GCK (GCK) Antibodies

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anti-Mouse (Murine) GCK Antibodies:

anti-Rat (Rattus) GCK Antibodies:

anti-Human GCK Antibodies:

All available anti-GCK Antibodies

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Top referenced anti-GCK Antibodies

  1. Human Polyclonal GCK Primary Antibody for EIA, IF - ABIN360273 : Pruhova, Ek, Lebl, Sumnik, Saudek, Andel, Pedersen, Hansen: Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha. in Diabetologia 2003 (PubMed)
    Show all 5 references for ABIN360273

  2. Human Polyclonal GCK Primary Antibody for EIA, IHC (p) - ABIN360274 : Chen, He, Wang, Zhao, Zhang: Expression of TNF-related apoptosis-inducing Ligand receptors and antitumor tumor effects of TNF-related apoptosis-inducing Ligand in human hepatocellular carcinoma. in World journal of gastroenterology : WJG 2003 (PubMed)
    Show all 5 references for ABIN360274

  3. Human Monoclonal GCK Primary Antibody for ELISA, WB - ABIN969172 : Barbetti, Cobo-Vuilleumier, Dionisi-Vici, Toni, Ciampalini, Massa, Rodriguez-Bada, Colombo, Lenzi, Garcia-Gimeno, Bermudez-Silva, Rodriguez de Fonseca, Banin, Aledo, Baixeras, Sanz, Cuesta-Muñoz: Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene. in Molecular endocrinology (Baltimore, Md.) 2009 (PubMed)
    Show all 2 references for ABIN969172

  4. Human Polyclonal GCK Primary Antibody for FACS, IF - ABIN411493 : Huang, Chou, Lee, Chen, Chen, Tao, Shih: MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ. in RNA (New York, N.Y.) 2015 (PubMed)

More Antibodies against GCK Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. This study using immunoreactive techniques, we have demonstrated in those specific areas of the rainbow trout brain previously described as glucosensor the presence of glucokinase in different cell types.

Xenopus laevis Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GKRP (show GCKR Antibodies) binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

Mouse (Murine) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.

  2. Absence of Gck expression did not prevent the glucose responsiveness of glucose-excited or glucose-inhibited Sf1 (show SF1 Antibodies) neurons in either sex. Thus Gck in the VMN plays a sex-specific role in the glucose-dependent control of autonomic nervous activity; this is, however, unrelated to the control of the firing activity of classical glucose-responsive neurons.

  3. Using a mutant GCK gene (GCK 262) with a knocked out cytosine at position 2643 results in lower protein expression and more ubiquitination-led protein degradation compared with wild-type GCK (GCK 261)

  4. lncLGR facilitates the recruitment of hnRNPL (show HNRNPL Antibodies) to the GCK promoter and suppresses GCK transcription.

  5. Given that acetylated GKRP (show GCKR Antibodies) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR Antibodies) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR Antibodies) pathway, for treating T2DM and other metabolic pathologies.

  6. These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin (show INS Antibodies) secretion through regulation of cytoplasmic Ca(2 (show CA2 Antibodies)+) levels.

  7. GHR (show GHR Antibodies) knockdown caused increased glucokinase mRNA and protein levels.

  8. results suggest that chronic suppression of hepatic glucokinase has a small influence on intertissue (liver-to-BAT (show BAAT Antibodies) as well as liver-to-beta-cell) metabolic communication

  9. Atf3 (show ATF3 Antibodies)-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin (show INS Antibodies) resistance.

  10. Suggest heterozygous glucokinase knockout mouse as a translatable model of human type 2 diabetes.

Human Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.

  2. GCK mutations are associated with MODY2.

  3. Glucokinase mutations are associated with Maturity-Onset Diabetes of the Young.

  4. The results show that p.Leu77Arg but not p.Val101Met GCK mutation is considered a pathogenic mutation associated with maturity onset diabetes of the young.

  5. GCK mutations are associated with Maturity onset diabetes of youth.

  6. glucokinase mutation is associated with Maturity-Onset Diabetes of the Young, Type 2.

  7. The number of mutations in GCK/MODY2 or even other MODY (show HNF4A Antibodies)-related genes is undoubtedly underestimated, as accepted criteria for performing genetic tests include family history of the pathology.

  8. Plasma ghrelin (show GHRL Antibodies) is higher in glucokinase-maturity onset diabetes of the young than in the common polygenic forms of diabetes.

  9. Given that acetylated GKRP (show GCKR Antibodies) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR Antibodies) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR Antibodies) pathway, for treating T2DM and other metabolic pathologies.

  10. The results of this study showed that mutations in the GCK gene are the leading cause of maturity-onset diabetes of the young in our population

GCK Antigen Profile

Antigen Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Alternative names and synonyms associated with GCK

  • glucokinase (hexokinase 4) (GCK) antibody
  • glucokinase (GCK) antibody
  • glucokinase (glcK) antibody
  • glucokinase (Bphyt_1025) antibody
  • glucokinase (Halhy_6548) antibody
  • glucokinase (gk) antibody
  • glucokinase (hexokinase 4) (gck) antibody
  • glucokinase (Gck) antibody
  • glucokinase (LOC100341946) antibody
  • glucokinase (hexokinase 4) (Gck) antibody
  • mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2) antibody
  • AI385662 antibody
  • BA4487 antibody
  • BL44 antibody
  • FGQTL3 antibody
  • GCK antibody
  • gck-A antibody
  • GK antibody
  • GLK antibody
  • Gls006 antibody
  • glucokinase antibody
  • GLUKA antibody
  • HHF3 antibody
  • HK4 antibody
  • HKIV antibody
  • HXKP antibody
  • LGLK antibody
  • MODY2 antibody
  • Rab8ip antibody
  • RNGK2 antibody

Protein level used designations for GCK

glucokinase , hexokinase 4 , HK IV , hexokinase type IV , hexokinase-4 , hexokinase-D , HK4 , ATP:D-hexose 6-phosphotransferase , hexokinase D, pancreatic isozyme , glucokinase (hexokinase 4, maturity onset diabetes of the young 2) , MAPK/ERK kinase kinase kinase 2 , MEK kinase kinase 2 , MEKKK 2 , RAB8 interacting protein , germinal center kinase , mitogen activated protein kinase kinase kinase kinase 2 , rab8-interacting protein

GENE ID SPECIES
100051836 Equus caballus
374086 Gallus gallus
606490 Canis lupus familiaris
1087979 Bacillus anthracis str. Ames
2797963 Listeria monocytogenes serotype 4b str. F2365
3728664 Carboxydothermus hydrogenoformans Z-2901
6284349 Burkholderia phytofirmans PsJN
10590758 Haliscomenobacter hydrossis DSM 1100
100135866 Oncorhynchus mykiss
378602 Xenopus laevis
100124905 Xenopus (Silurana) tropicalis
103988 Mus musculus
24385 Rattus norvegicus
100341946 Oryctolagus cuniculus
2645 Homo sapiens
100037406 Felis catus
616576 Bos taurus
430370 Gallus gallus
100514142 Sus scrofa
100717630 Cavia porcellus
26412 Mus musculus
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