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Rat (Rattus) HIF1A ELISA Kit for Sandwich ELISA - ABIN416136
Chen, Pan, Liu, Chen, Liu, Yeh, Tsai, Young, Zhang, Chao: The effects and underlying mechanisms of S-allyl l-cysteine treatment of the retina after ischemia/reperfusion. in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2012
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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN414447
Lu, Jiang, Chen, Xu, Hu, Zhao, Gao, Guo: Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis. in PLoS ONE 2013
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Mouse (Murine) HIF1A ELISA Kit for Sandwich ELISA - ABIN424082
Du, Lin, Wang, Zhang, Wu, Lu, Ji, Yu: Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1? in tumor and normal cells. in Cancer chemotherapy and pharmacology 2011
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Rat (Rattus) HIF1A ELISA Kit for Sandwich ELISA - ABIN368077
Rodríguez-Gómez, Banegas, Wangensteen, Quesada, Jiménez, Gómez-Morales, OValle, Duarte, Vargas: Influence of thyroid state on cardiac and renal capillary density and glomerular morphology in rats. in The Journal of endocrinology 2013
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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN366532
Jiang, Tang, Guo, Jiao: The role of insulin-like growth factor I and hypoxia inducible factor 1α in vascular endothelial growth factor expression in type 2 diabetes. in Annals of clinical and laboratory science 2013
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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN2344926
Ohyama, Toyomura, Tachibana, Isonishi, Takahashi, Ishikawa: Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary. in Human cell 2016
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN1081535
Sun, Wang, Liu, Lin, Hua: Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1? protein. in Molecular medicine reports 2014
Pig (Porcine) HIF1A ELISA Kit for Sandwich ELISA - ABIN368480
Gyöngyösi, Hemetsberger, Posa, Charwat, Pavo, Petnehazy, Petrasi, Pavo, Hemetsberger, Benedek, Benedek, Benedek, Kovacs, Kaun, Maurer: Hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction. in Journal of cardiovascular translational research 2010
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN1115458
Chandravanshi, Bhonde: Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia. in European journal of pharmacology 2016
induction of HIF-1alpha mediated transcriptional up-regulation of pro-apoptotic/inflammatory signaling contributes to astrocyte cell death during thiamine deficiency.
Smad3 (show SMAD3 ELISA Kits) binding to the -335 hypoxia-responsive element of the COL1A2 (show COL1A2 ELISA Kits) promoter required HIF-1alpha both in vitro and in kidney lysate from the disease model, suggesting formation of an HIF-1alpha-Smad3 (show SMAD3 ELISA Kits) transcriptional complex. Thus, HIF-1alpha-Smad3 (show SMAD3 ELISA Kits) has a novel interaction in glomerulosclerosis.
These results suggest that cyclosporine A (CsA (show HSPA9 ELISA Kits)) exhibits antifibrotic effects by degrading HIF-1alpha and that the CsA (show HSPA9 ELISA Kits)-HIF-1alpha axis provides new insights into therapeutic options for the treatment of pulmonary fibrosis.
HIF-1alpha protein levels in the ipsilateral hemisphere were higher in the WT mice than Par-1 (show MARK2 ELISA Kits) KO mice after glioma cell implantation.
We conclude that HIF-1 is not a major regulator of Vegfa (show VEGFA ELISA Kits) expression during wound healing; rather, it serves to maintain basal levels of expression of Vegfa (show VEGFA ELISA Kits) and its target genes in intact skin, which are required for optimal granulation tissue formation in response to wounding.
hypoxic IL-22 (show IL22 ELISA Kits) upregulation is dependent on HIF-1alpha
Lactic Acid Suppresses IL-33 (show IL33 ELISA Kits)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (show MLXIP ELISA Kits)-155 Suppression
HIF-1alpha and GDF15 (show GDF15 ELISA Kits) expression are inversely related under normoxia and hyperoxia.
HIF-1alpha induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (show MLXIP ELISA Kits)-21 via inhibiting a novel target gene TSP-1 (show GZMA ELISA Kits). Both of them may contribute to the protective effect of HIF-1alpha on renal I/R injury.
Knockdown or knockout of PHF8 (show PHF8 ELISA Kits) by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha.
HIF-1alpha overexpression is associated with oral squamous cell carcinoma.
Single-nucleotide polymorphism in HIF1A gene is associated with breast cancers.
Data suggest the possibility of testing hypoxia-inducible factor 1, alpha subunit (show POLG ELISA Kits) (HIF-1alpha) stabilizer PHD (show PDC ELISA Kits) inhibitors FG-449 to boost hematopoietic stem progenitor cells (HSPCs) mobilization in response to granulocyte colony-stimulating factor (G-CSF (show CSF3 ELISA Kits)) in humans.
Thyroid hormone (show PTH ELISA Kits) T3 induces fibronectin (show FN1 ELISA Kits) and HIF-1alpha synthesis via PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.
The study identifies an unanticipated role for the X-linked inhibitor of apoptosis (XIAP (show XIAP ELISA Kits)) protein as a regulator of Lys63-linked polyubiquitination of HIF1alpha.
We will also describe distinct crossroads between the regulation of longevity and cancer, e.g. specific regulation through the AMPKalpha (show GRK4 ELISA Kits) and HIF-alpha isoforms, the Warburg effect, mitochondrial dynamics, and cellular senescence. [review]
The authors demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depletion in low oxygen conditions, drastically abolishes hypoxic responses including angiogenesis. In addition, the data indicate an interaction of miR675-5p, HIF-1alpha mRNA and the RNA Binding Protein (show PTBP1 ELISA Kits) HuR (show ELAVL1 ELISA Kits) in hypoxia-induced responses.
Age-related increase is found in FtMt (show FTMT ELISA Kits) and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin (show FTMT ELISA Kits).
Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans, and suggest that it may be a new biomarker for placental insufficiency.
a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (show HSP70 ELISA Kits)) was noted
Induction of ischemic osteonecrosis results in IL-6 (show IL6 ELISA Kits) production in the articular cartilage through an HIF-1-dependent pathway.
Upregulation of VEGF (show VEGFA ELISA Kits) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
HIF-1alpha activates Sox9 (show SOX9 ELISA Kits) expression and enhances Sox9 (show SOX9 ELISA Kits)-mediated transcriptional activity.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 ELISA Kits) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 ELISA Kits) was present at sites of intramembranous ossification
Downregulation of miR (show MYLIP ELISA Kits)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 ELISA Kits) and recapitulates hypoxia preconditioning in cardiac myocytes.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.
inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow
Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.
hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity
VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself
Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
HIF-1alpha-induced HSP70 (show HSP70 ELISA Kits) overexpression increased the expression levels of ECM (show MMRN1 ELISA Kits) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 ELISA Kits) expression
Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.
Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.
HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.
Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1
Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.
rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.
Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion
blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.
HIF-1-mediated activation of 5-HT (show DDC ELISA Kits) signalling promotes axon regeneration by activating both the RhoA (show RHOA ELISA Kits) and cAMP pathways.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 ELISA Kits)).
AMPK (show PRKAA1 ELISA Kits) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 ELISA Kits)
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 ELISA Kits) compromised C. elegans dauer larvae.
These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.
Data show that that reactive oxygen species (ROS (show ROS1 ELISA Kits)) are increased in respiration mutants and that mild increases in ROS (show ROS1 ELISA Kits) can stimulate HIF-1 to activate gene expression and promote longevity.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, HIF1 alpha
, Hypoxia-inducible factor 1 alpha
, hypoxia-inducible factor 1-alpha
, ARNT-interacting protein
, ARNT interacting protein
, PAS domain-containing protein 8
, basic-helix-loop-helix-PAS protein MOP1
, class E basic helix-loop-helix protein 78
, hypoxia-inducible factor 1 alpha isoform I.3
, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
, hypoxia-inducible factor1alpha
, member of PAS protein 1
, member of PAS superfamily 1
, hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha subunit
, hypoxia inducible factor 1, alpha subunit