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Browse our Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A)

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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A)
On www.antibodies-online.com are 50 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Proteins from 13 different suppliers available. Additionally we are shipping Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies (651) and Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (75) and many more products for this protein. A total of 790 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) products are currently listed.
Synonyms:
AA959795, bHLHe78, hif-1a, HIF-1alpha, HIF1, HIF1-alpha, hif1a, HIF1alpha, MOP1, PASD8
list all proteins Gene Name GeneID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
HIF1A 29560 O35800

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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A) by Origin

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Top referenced Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins

  1. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN2004948 : Carbia-Nagashima, Gerez, Perez-Castro, Paez-Pereda, Silberstein, Stalla, Holsboer, Arzt: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. in Cell 2007 (PubMed)
    Show all 5 references for ABIN2004948

  2. Human HIF1A Protein expressed in Wheat germ - ABIN1306618 : Vadivel, Alphonse, Etches, van Haaften, Collins, OReilly, Eaton, Thébaud: Hypoxia-inducible factors promote alveolar development and regeneration. in American journal of respiratory cell and molecular biology 2014 (PubMed)
    Show all 3 references for ABIN1306618

  3. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN667224 : Okuyama, Krishnamachary, Zhou, Nagasawa, Bosch-Marce, Semenza: Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. in The Journal of biological chemistry 2006 (PubMed)

More Proteins for Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Interaction Partners

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. oxygen, via HIF1alpha activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet (show FBXL15 Proteins) lag (show STMN1 Proteins).

  2. induction of clock and HIF1alpha target genes in response to strenuous exercise varied according to the time of day in wild-type mice.

  3. HIF-1alpha activation via cytosolic Ca(2 (show CA2 Proteins)+) signaling pathway play a role in the mechanism of isoflurane-induced neurodegeneration in neonatal rodents, suggesting HIF-1alpha as a potential therapeutic target for the prevention of the deleterious effects of prolonged exposures to anesthetics.

  4. these data show a key role for HIF-1alpha in regulating the expression of CD55 (show CD55 Proteins) on airway epithelium.

  5. Results suggest that sustained activation of HIF-1alpha through dimethyloxaloylglycine administration provides significant neuroprotection following traumatic brain injury

  6. Deficiency of smooth muscle cell-derived hypoxia-inducible factor-1alpha augments aortic aneurysms, accompanied by disruption of elastin (show ELN Proteins) fiber formation, but not changes of elastin (show ELN Proteins) fiber degradation.

  7. HIF-1alpha expression in macrophages affects their intrinsic inflammatory profile and promotes development of atherosclerosis.

  8. A deficiency of KLF2 (show KLF2 Proteins) increased the expression of Notch ligand (show JAG2 Proteins) Jagged2 (show JAG2 Proteins) via hypoxia-inducible factor 1alpha (HIF-1alpha), which led to Th2 amplification.

  9. These findings reveal VHL (show VHL Proteins)-HIF-mediated metabolic compartmentalization in the developing heart and the connection between metabolism and myocardial differentiation.

  10. The authors determined that siderophore-secreting Klebsiella pneumoniae stabilized HIF-1alpha in vivo and that bacterial dissemination to the spleen required alveolar epithelial HIF-1alpha.

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. SMARCE1 (show SMARCE1 Proteins) plays an essential role in breast cancer metastasis by protecting cells against anoikis through the HIF1A/PTK2 (show PTK2 Proteins) pathway.

  2. the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (show HDAC5 Proteins) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 (show HIPK2 Proteins) in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (show HDAC5 Proteins)-homeodomain-interacting protein kinase-2 (show HIPK2 Proteins)-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.

  3. Univariate analysis of the overall survival demonstrates that HIF-2a expression but not HIF-1a was related to poor outcome ( p = 0.005) and it retained significance in multivariate analysis ( p = 0.046). In conclusion, HIF-2a expression was related to tumor size, lymph node metastasis, tumor stage and histology. We also found a positive prognostic value of HIF-2a protein expression.

  4. Data suggest that, compared with obese white women, obese black women exhibit higher expression of HIF1A (hypoxia inducible factor 1 alpha), COL5A1 (collagen Valpha1), and COL6A1 (show COL6A1 Proteins) (collagen VIalpha1) in gluteal but not abdominal subcutaneous adipose tissue depots; up-regulation of expression of these proteins correlates with reduced insulin (show INS Proteins) sensitivity in black women only.

  5. HIF1alpha and LDH5 are markers of poor outcome in patients with bladder cancer treated with radiotherapy. Blockage of anaerobic metabolism may prove of importance in clinical radiotherapy.

  6. No association has been found between HIF1A and VEGFR2 (show KDR Proteins) SNPs and the development of chronic obstructive pulmonary disease.

  7. Hypoxia and upregulated HIF-1a both upregulated the P2Y2 (show P2RY2 Proteins) levels in hepatocellular carcinoma cells and increased their survival.

  8. showed that NF-KBp50, p65 (show GORASP1 Proteins) and HIF1a form higher order heteromultimeric complexes overlapping rs7901656, implying synergism of action among TFs governing cellular response to infection and hypoxia

  9. oxoglutarate dehydrogenase (OGDH (show alphaKGDHC Proteins)) and lipoic acid synthase (LIAS (show LIAS Proteins)), which when mutated stabilize HIF1alpha in a non-hydroxylated form.

  10. HIF-1alpha and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (show HSP70 Proteins)) was noted

  2. Induction of ischemic osteonecrosis results in IL-6 (show IL6 Proteins) production in the articular cartilage through an HIF-1-dependent pathway.

  3. Upregulation of VEGF (show VEGFA Proteins) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  4. HIF-1alpha activates Sox9 (show SOX9 Proteins) expression and enhances Sox9 (show SOX9 Proteins)-mediated transcriptional activity.

  5. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  6. immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Proteins) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Proteins) was present at sites of intramembranous ossification

  7. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Proteins) and recapitulates hypoxia preconditioning in cardiac myocytes.

  8. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow

  2. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  3. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  4. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  5. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (show HSP70 Proteins) overexpression increased the expression levels of ECM (show MMRN1 Proteins) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Proteins) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.

  2. HIF-1-mediated activation of 5-HT (show DDC Proteins) signalling promotes axon regeneration by activating both the RhoA (show RHOA Proteins) and cAMP pathways.

  3. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Proteins)).

  4. AMPK (show PRKAA1 Proteins) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Proteins)

  5. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  6. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Proteins) compromised C. elegans dauer larvae.

  7. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  8. Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Proteins), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Proteins) and hydrogen cyanide.

  9. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  10. Data show that that reactive oxygen species (ROS (show ROS1 Proteins)) are increased in respiration mutants and that mild increases in ROS (show ROS1 Proteins) can stimulate HIF-1 to activate gene expression and promote longevity.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Protein Profile

Protein Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)

  • hypoxia inducible factor 1 alpha (hif-1a)
  • hypoxia inducible factor 1, alpha subunit (Hif1a)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • hypoxia-inducible factor 1 alpha (hif-1a)
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • Protein HIF-1 (hif-1)
  • AA959795 protein
  • bHLHe78 protein
  • hif-1a protein
  • HIF-1alpha protein
  • HIF1 protein
  • HIF1-alpha protein
  • hif1a protein
  • HIF1alpha protein
  • MOP1 protein
  • PASD8 protein

Protein level used designations for HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPECIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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