Browse our Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A)

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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A)
On www.antibodies-online.com are 50 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Proteins from 13 different suppliers available. Additionally we are shipping Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies (665) and Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (81) and many more products for this protein. A total of 811 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) products are currently listed.
Synonyms:
AA959795, bHLHe78, hif-1a, HIF-1alpha, HIF1, HIF1-alpha, hif1a, HIF1alpha, MOP1, PASD8
list all proteins Gene Name GeneID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
HIF1A 29560 O35800

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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A) by Origin

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Top referenced Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins

  1. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN2004948 : Carbia-Nagashima, Gerez, Perez-Castro, Paez-Pereda, Silberstein, Stalla, Holsboer, Arzt: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. in Cell 2007 (PubMed)
    Show all 5 references for 2004948

  2. Human HIF1A Protein expressed in Wheat germ - ABIN1306618 : Vadivel, Alphonse, Etches, van Haaften, Collins, OReilly, Eaton, Thébaud: Hypoxia-inducible factors promote alveolar development and regeneration. in American journal of respiratory cell and molecular biology 2014 (PubMed)
    Show all 3 references for 1306618

  3. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN667163 : Okuyama, Krishnamachary, Zhou, Nagasawa, Bosch-Marce, Semenza: Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. in The Journal of biological chemistry 2006 (PubMed)

More Proteins for Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Interaction Partners

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. We conclude that HIF-1 is not a major regulator of Vegfa (show VEGFA Proteins) expression during wound healing; rather, it serves to maintain basal levels of expression of Vegfa (show VEGFA Proteins) and its target genes in intact skin, which are required for optimal granulation tissue formation in response to wounding.

  2. hypoxic IL-22 (show IL22 Proteins) upregulation is dependent on HIF-1alpha

  3. Lactic Acid Suppresses IL-33 (show IL33 Proteins)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (show MLXIP Proteins)-155 Suppression

  4. Lactic Acid Suppresses IL-33 (show IL33 Proteins)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (show MLXIP Proteins)-155 Suppression

  5. HIF-1alpha and GDF15 (show GDF15 Proteins) expression are inversely related under normoxia and hyperoxia.

  6. HIF-1alpha induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (show MLXIP Proteins)-21 via inhibiting a novel target gene TSP-1 (show GZMA Proteins). Both of them may contribute to the protective effect of HIF-1alpha on renal I/R injury.

  7. studies in humans and mice reveal that Akt2 (show AKT2 Proteins) controls hepatic tumorigenesis through crosstalk between HNF1alpha (show HNF1A Proteins) and PPARgamma (show PPARG Proteins).

  8. We conclude that HIF1alpha is activated in alveolar type II cells after lung injury and promotes proliferation and spreading during repair.

  9. HIF1alpha-dependent glycolytic activity is responsible for mTOR (show FRAP1 Proteins)-deficient, increased myeloid-derived suppressive cell functional changes in IMH inflammation.

  10. Activation of HIF1A by prolonged in vivo hyperinsulinemia potentiates cancerous progression in estrogen receptor (show ESR1 Proteins)-positive breast cancer cells.

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. HIF1a is elevated in HUVECs exposed to heme and treatment with hydroxyurea and simvastatin reduced the production.

  2. Results indicated that hypoxia-induced Mxd1 (show MXD1 Proteins) expression was mediated by HIF-1alpha in osteosarcoma cells.

  3. HIF-1alpha was destabilised in the presence of bile acids in all tested, human tumor cell lines.

  4. these data suggest that HIF-1alpha expression represents a candidate prognostic biomarker for clinical application in high-grade leiomyosarcoma and undifferentiated pleomorphic sarcoma

  5. HIF-1alpha and GDF15 (show GDF15 Proteins) expression are inversely related under normoxia and hyperoxia.

  6. Our findings suggest that GATA3 (show GATA3 Proteins) stabilizes HIF-1alpha to enhance cancer invasiveness under hypoxia

  7. Aldolase A promotes lung cancer metastasis via PHD (show PDC Proteins)-mediated stabilization of HIF-1alpha and the subsequent activation of MMP9 (show MMP9 Proteins).

  8. Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha) is phylogenetically conserved among most metazoans, whereas HIF-2alpha (show EPAS1 Proteins) protein appeared later.

  9. present study identifies the crucial regulation of hsa_circ_0010729 on vascular endothelial cell proliferation and apoptosis via targeting miR (show MLXIP Proteins)-186/HIF-1alpha axis

  10. TrpC5 (show TRPC5 Proteins) induces the epithelial-mesenchymal transition through the HIF-1alpha-Twist signaling pathway to promote tumor metastasis in colon cancer.

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (show HSP70 Proteins)) was noted

  2. Induction of ischemic osteonecrosis results in IL-6 (show IL6 Proteins) production in the articular cartilage through an HIF-1-dependent pathway.

  3. Upregulation of VEGF (show VEGFA Proteins) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  4. HIF-1alpha activates Sox9 (show SOX9 Proteins) expression and enhances Sox9 (show SOX9 Proteins)-mediated transcriptional activity.

  5. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  6. immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Proteins) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Proteins) was present at sites of intramembranous ossification

  7. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Proteins) and recapitulates hypoxia preconditioning in cardiac myocytes.

  8. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow

  2. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  3. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  4. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  5. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (show HSP70 Proteins) overexpression increased the expression levels of ECM (show MMRN1 Proteins) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Proteins) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.

  2. HIF-1-mediated activation of 5-HT (show DDC Proteins) signalling promotes axon regeneration by activating both the RhoA (show RHOA Proteins) and cAMP pathways.

  3. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Proteins)).

  4. AMPK (show PRKAA1 Proteins) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Proteins)

  5. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  6. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Proteins) compromised C. elegans dauer larvae.

  7. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  8. Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Proteins), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Proteins) and hydrogen cyanide.

  9. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  10. Data show that that reactive oxygen species (ROS (show ROS1 Proteins)) are increased in respiration mutants and that mild increases in ROS (show ROS1 Proteins) can stimulate HIF-1 to activate gene expression and promote longevity.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Protein Profile

Protein Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)

  • hypoxia inducible factor 1 alpha (hif-1a)
  • hypoxia inducible factor 1, alpha subunit (Hif1a)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • hypoxia-inducible factor 1 alpha (hif-1a)
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • Protein HIF-1 (hif-1)
  • AA959795 protein
  • bHLHe78 protein
  • hif-1a protein
  • HIF-1alpha protein
  • HIF1 protein
  • HIF1-alpha protein
  • hif1a protein
  • HIF1alpha protein
  • MOP1 protein
  • PASD8 protein

Protein level used designations for HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPECIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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