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Browse our Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A)

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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A)
On www.antibodies-online.com are 53 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Proteins from 14 different suppliers available. Additionally we are shipping Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies (668) and Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (65) and many more products for this protein. A total of 800 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) products are currently listed.
Synonyms:
AA959795, bHLHe78, hif-1a, HIF-1alpha, HIF1, HIF1-alpha, hif1a, HIF1alpha, MOP1, PASD8
list all proteins Gene Name GeneID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
HIF1A 29560 O35800

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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (HIF1A) by Origin

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Top referenced Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins

  1. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN2004948 : Carbia-Nagashima, Gerez, Perez-Castro, Paez-Pereda, Silberstein, Stalla, Holsboer, Arzt: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. in Cell 2007 (PubMed)
    Show all 5 references for ABIN2004948

  2. Human HIF1A Protein expressed in Wheat germ - ABIN1306618 : Vadivel, Alphonse, Etches, van Haaften, Collins, OReilly, Eaton, Thébaud: Hypoxia-inducible factors promote alveolar development and regeneration. in American journal of respiratory cell and molecular biology 2014 (PubMed)
    Show all 3 references for ABIN1306618

  3. Human HIF1A Protein expressed in Escherichia coli (E. coli) - ABIN667224 : Okuyama, Krishnamachary, Zhou, Nagasawa, Bosch-Marce, Semenza: Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. in The Journal of biological chemistry 2006 (PubMed)

More Proteins for Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Interaction Partners

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. methylation-based regulation of HIF-1alpha stability constitutes another layer of regulation that is independent of previously identified mechanisms.

  2. The in vivo anti-tumoral effect of lenalidomide is enhanced by HIF-1alpha suppression in myeloma cells.

  3. Overall, these data indicate that hypoxia or HIF-1alpha positively regulates MEF expression and function.

  4. our study demonstrated that over-expressing miR (show MLXIP Proteins)-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI (show CLU Proteins)) through enhancing HIF-1alpha activity by targeting CHIP, which may hold great therapeutic promise in treating CLI (show CLU Proteins)

  5. Chronic intermittent hypoxia induced an increase in endoplasmic reticulum stress markers and HIF-1 activity.

  6. Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR (show MLXIP Proteins)-122-mediated HIF-1alpha activation.

  7. Glrx (show GRX1 Proteins) ablation stabilizes HIF-1alpha by increasing GSH adducts on Cys (show DNAJC5 Proteins)(520) promoting in vivo HIF-1alpha stabilization, VEGF-A (show VEGFA Proteins) production, and revascularization in the ischemic muscles.

  8. RANTES (show CCL5 Proteins) produced by renal tubular cells act as a key chemokine (show CCL1 Proteins) in acute kidney injury and HIF-1alpha regulated LncRNA-PRINS might be involved in RANTES (show CCL5 Proteins) production.

  9. The positive correlation between DeltaR2(*) and HIF-2alpha, but not HIF-1alpha, suggested potential role of combined BOLD-MRI technique and HIF-1alpha staining in clinical diagnosis of renal carcinoma.

  10. Attenuated HIF-1alpha exacerbates the oxidative stress injury by advanced glycation end products in murine Leydig cells, and contributes to diabetic male infertility

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Obstructive sleep apnea-hypopnea syndrome pathogenesis was associated with changes in NF-kappaB (show NFKB1 Proteins), HIF-1alpha, and SPD (show HOXD13 Proteins) protein expression level

  2. HIF-1alpha is involved in the up-regulation of Notch (show NOTCH1 Proteins) genes in the hepatocellular carcinoma.

  3. HIF-1 alpha gene expression increased in earlier up to metastasis stages of CRC (show CALR Proteins), but the assessment of HIF-1 alpha gene expression has not important role in the diagnosis of cancer in early stages and classification of carcinoma because the increasing of HIF-1 alpha gene expression is not significant in early cancer stages.

  4. HIF-1alpha and VEGF (show VEGFA Proteins) expression was significantly related to liver tumor stage and lymph nodes and lung metastases (P < 0.05). HIF-1alpha expression correlated with VEGF (show VEGFA Proteins) expression in PLC (show HSPG2 Proteins) (r = 0.665, P < 0.05).

  5. We show that the combination of GLDC (show GLDC Proteins) and HIF-1alpha expression is an independent prognostic factor in early-stage lung non-small cell cancer

  6. LPA2 (show LPAR2 Proteins) expression was associated with HIF-1alpha expression and that a high level of LPA2 (show LPAR2 Proteins) was associated with shorter overall survival and was an independent prognostic predictor for breast cancer in Chinese women.

  7. Review of recent findings on the important roles of HIF-1alpha in immune cells and the possible pathologic roles of HIF-1alpha in autoimmune diseases.

  8. The PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway is also involved in regulating HSP70 (show HSP70 Proteins)/HIF-1alpha expression.

  9. Parkin (show PARK2 Proteins) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  10. HIF1a expression was observed in 44.8% of oral squamous cell carcinoma. HIF1a was expressed in the cytoplasm and cell membranes, and partially in the nucleus .

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Induction of ischemic osteonecrosis results in IL-6 (show IL6 Proteins) production in the articular cartilage through an HIF-1-dependent pathway.

  2. Upregulation of VEGF (show VEGFA Proteins) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  3. HIF-1alpha activates Sox9 (show SOX9 Proteins) expression and enhances Sox9 (show SOX9 Proteins)-mediated transcriptional activity.

  4. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  5. immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Proteins) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Proteins) was present at sites of intramembranous ossification

  6. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Proteins) and recapitulates hypoxia preconditioning in cardiac myocytes.

  7. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  2. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  3. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  4. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (show HSP70 Proteins) overexpression increased the expression levels of ECM (show MMRN1 Proteins) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Proteins) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. HIF-1-mediated activation of 5-HT (show DDC Proteins) signalling promotes axon regeneration by activating both the RhoA (show RHOA Proteins) and cAMP pathways.

  2. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Proteins)).

  3. AMPK (show PRKAA1 Proteins) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Proteins)

  4. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  5. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Proteins) compromised C. elegans dauer larvae.

  6. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  7. Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Proteins), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Proteins) and hydrogen cyanide.

  8. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  9. Data show that that reactive oxygen species (ROS (show ROS1 Proteins)) are increased in respiration mutants and that mild increases in ROS (show ROS1 Proteins) can stimulate HIF-1 to activate gene expression and promote longevity.

  10. These data support a model in which SWAN-1 (show DCAF7 Proteins), MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 (show SMOX Proteins) fast killing.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Protein Profile

Protein Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)

  • hypoxia inducible factor 1 alpha (hif-1a)
  • hypoxia inducible factor 1, alpha subunit (Hif1a)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • hypoxia-inducible factor 1 alpha (hif-1a)
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a)
  • Protein HIF-1 (hif-1)
  • AA959795 protein
  • bHLHe78 protein
  • hif-1a protein
  • HIF-1alpha protein
  • HIF1 protein
  • HIF1-alpha protein
  • hif1a protein
  • HIF1alpha protein
  • MOP1 protein
  • PASD8 protein

Protein level used designations for HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPECIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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