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Human Monoclonal ISL1 Primary Antibody for BI, IHC (f) - ABIN2689799
Bu, Jiang, Martin-Puig, Caron, Zhu, Shao, Roberts, Huang, Domian, Chien: Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. in Nature 2009
Show all 7 Pubmed References
Human Monoclonal ISL1 Primary Antibody for IF, ELISA - ABIN561536
Guo, Wang, Zhang, Liu, Chen, Ma, Zhou: ISL1 promotes pancreatic islet cell proliferation. in PLoS ONE 2011
Show all 5 Pubmed References
Human Monoclonal ISL1 Primary Antibody for ICC, ELISA - ABIN969220
Elshatory, Gan: The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.
Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.
Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1 (show CCNB1 Antibodies)), cyclin B2 (CCNB2 (show CCNB2 Antibodies)) and c-myc (c-MYC (show MYC Antibodies)) genes by binding to the conserved binding sites on their promoters or enhancers.
results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations.
ISL-1 is widely expressed in Olfactory neuroblastoma (show ARHGEF16 Antibodies) tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis
Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway showed increased gene expression of ISL1, OCT4 (show POU5F1 Antibodies), KDR (show KDR Antibodies) and NKX2.5 (show NKX2-5 Antibodies).
In bladder exstrophy there is a clear correlation with the a mutation of the chromosome 5 ISL1 (5q11.1) gene.
SSBP3 (show SSBP3 Antibodies) Interacts With Islet-1 and Ldb1 (show LDB1 Antibodies) to Impact Pancreatic beta-Cell Target Genes
Concurrent ISL1/HOXA9 (show HOXA9 Antibodies) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality
Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.
The present study identified the first genome-wide significant locus for classic bladder exstrophy at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.
Suggest that ISL-1 may be a useful prognostic biomarker and may represent a novel therapeutic target for gastric adenocarcinoma.
CITED2 (show CITED2 Antibodies) and ISL1 proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes.
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (show PAX6 Antibodies) and the LIM protein (show PDLIM1 Antibodies) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
PDX1 (show PDX1 Antibodies) and ISL1 regulation of insulin (show INS Antibodies) gene expression in pancreatic beta cells, was investigated.
Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 (show LHX3 Antibodies) in nascent motor neurons and Isl1/Onecut1 (show ONECUT1 Antibodies) in maturing hypaxial motor neurons.
These data reveal functional roles for an ISLET1-dependent network integrating beta-catenin (show CTNNB1 Antibodies)/SHH (show SHH Antibodies) signals in mesenchymal cell survival and outgrowth of the mandible during development.
ISL1 and JMJD3 (show Kdm6b Antibodies) partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.
Pax2 (show PAX2 Antibodies)-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
These results show that ISL1 is necessary for maximal thyrotrope response to hypothyroidism, in addition to its role in development of Rathke's pouch.
the Isl1/Ldb1 (show LDB1 Antibodies) complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.
prdm1a (show PRDM1 Antibodies) Regulates sox10 (show SOX10 Antibodies) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
Nkx6 proteins regulate MiP (show MIP Antibodies) motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP (show MIP Antibodies) subtype and to suppress interneuron development.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
, ISL1 transcription factor, LIM/homeodomain, (islet-1)
, domesticus (clone 1.7 kB) islet-1
, insulin gene enhancer protein ISL-1
, ISL1 transcription factor, LIM/homeodomain
, ISL1 transcription factor LIM/homeodomain (islet-1)
, ISL1 transcription factor, LIM/homeodomain 1
, isl-1 homeobox
, Insulin gene enhancer protein ISL-1
, Islet 1
, Lim-homeodomain protein Islet1
, insulin related protein
, insulin gene enhancer protein isl-1