Browse our anti-MCU (MCU) Antibodies

Full name:
anti-Mitochondrial Calcium Uniporter Antibodies (MCU)
On www.antibodies-online.com are 5 Mitochondrial Calcium Uniporter (MCU) Antibodies from 3 different suppliers available. Additionally we are shipping MCU Kits (12) and MCU Proteins (6) and many more products for this protein. A total of 23 MCU products are currently listed.
Synonyms:
2010012O16Rik, AV064928, C10orf42, Ccdc109a, D130073L02Rik, Gm64
list all antibodies Gene Name GeneID UniProt
MCU 90550 Q8NE86
MCU 215999 Q3UMR5

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Most Popular Reactivities for anti-MCU (MCU) Antibodies

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anti-Human MCU Antibodies:

anti-Mouse (Murine) MCU Antibodies:

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Top referenced anti-MCU Antibodies

  1. Human Polyclonal MCU Primary Antibody for ICC, IF - ABIN4288500 : Baughman, Perocchi, Girgis, Plovanich, Belcher-Timme, Sancak, Bao, Strittmatter, Goldberger, Bogorad, Koteliansky, Mootha: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. in Nature 2011 (PubMed)
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More Antibodies against MCU Interaction Partners

Human Mitochondrial Calcium Uniporter (MCU) interaction partners

  1. Here, the authors determine the transmembrane orientation of EMRE, and show that its known MCU-activating function is mediated by the interaction of transmembrane helices from both proteins.

  2. It has been shown that the propagation of the TRPV1 (show TRPV1 Antibodies)-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX (show SLC24A6 Antibodies) and MCU.

  3. Regulation of mitochondrial Ca(2 (show CA2 Antibodies)+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis.

  4. MCU downregulation hampered cell motility and invasiveness and reduced tumor growth, lymph node infiltration, and lung metastasis in triple-negative breast cancer xenografts. In MCU-silenced cells, production of mitochondrial reactive oxygen species (mROS) is blunted and expression of the hypoxia-inducible factor-1alpha (HIF-1alpha (show HIF1A Antibodies)) is reduced, suggesting a signaling role for mROS and HIF-1alpha (show HIF1A Antibodies), downstream of mitochon...

  5. Reveal a distinct functional role for Cys (show DNAJC5 Antibodies)-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity.

  6. Study indicates that inhibition of mitochondrial calcium uniporter can inhibit excessive mitophagy and protect the neurocytes from ischemia/reperfusion injury.

  7. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 (show MICU1 Antibodies) and an original approach to investigate MCU/EMRE activation in intact cells.

  8. Data suggest that MCU regulator (EMRE) might be a structural factor for opening of the mitochondrial calcium uniporter (MCU)-forming pore.

  9. results suggest that N terminal domain of MCU is essential for the modulation of MCU function, although it does not affect the uniplex formation

  10. MCU-VDAC1 (show VDAC1 Antibodies) complex regulates mitochondrial Ca(2 (show CA2 Antibodies)+) uptake and oxidative stress-induced (show SQSTM1 Antibodies) apoptosis

Mouse (Murine) Mitochondrial Calcium Uniporter (MCU) interaction partners

  1. MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.

  2. Regulation of mitochondrial Ca(2 (show CA2 Antibodies)+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis.

  3. Reveal a distinct functional role for Cys (show DNAJC5 Antibodies)-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity.

  4. The m-AAA (show AAAS Antibodies) protease associated with neurodegeneration limits MCU activity in mitochondria.

  5. Data show that the serine/threonine kinase (show CDK4 Antibodies) LKB1 (show STK11 Antibodies) regulates mitochondrial calcium uniporter (MCU)-expression, mitochondria-dependent Ca2 (show CA2 Antibodies)+ clearance, and thereby, presynaptic release properties.

  6. the Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 (show CA3 Antibodies) and CA1 (show CA1 Antibodies) regions in the adult hippocampus.

  7. Absence of MCU expression does not affect basal cardiac function at either 12 or 20months of age in knockout mice.

  8. MCU is required to match energetics with contractile demand during stress. Deletion of Mcu protects against myocardial IR injury.

  9. Mice lacking MCU in the heart show no pathology. MCU selectively mediates acute mitochondria Ca2 (show CA2 Antibodies)+ loading to augment ATP synthesis.

  10. MCU is necessary for complete physiological heart rate acceleration

MCU Antigen Profile

Antigen Summary

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with MCU

  • mitochondrial calcium uniporter (MCU) antibody
  • mitochondrial calcium uniporter (Mcu) antibody
  • 2010012O16Rik antibody
  • AV064928 antibody
  • C10orf42 antibody
  • Ccdc109a antibody
  • D130073L02Rik antibody
  • Gm64 antibody

Protein level used designations for MCU

calcium uniporter protein, mitochondrial , coiled-coil domain-containing protein 109A , coiled-coil domain containing 109A

GENE ID SPECIES
90550 Homo sapiens
215999 Mus musculus
489042 Canis lupus familiaris
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