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MCU expression returned to physiological levels in visceral adipose tissue of patients after weight loss by bariatric surgery. Altered mitochondrial calcium flux in fat cells may play a role in obesity and diabetes and may be associated with the differential metabolic profiles of visceral and subcutaneous adipose tissue.
Mitochondrial calcium uniporter plays an important role in hyperglycaemia-induced endothelial cell dysfunction.
The studies findings in aging human skeletal muscle confirm the data obtained in mice and propose mitochondrial calcium uniporter and mitochondria-related proteins as potential pharmacological targets to counteract age-related muscle loss.
decreased MCU expression in hypertensive with mutation cells contributed to dysregulated Ca(2 (show CA2 ELISA Kits)+) uptake into the mitochondria
The molecular structure and regulation of the MCU complex in addition to its pathophysiological role are discussed with particular attention to striated (show NSDHL ELISA Kits) muscle tissues. Review.
High MCU expression is associated with metastasis in hepatocellular carcinoma.
Here, the authors determine the transmembrane orientation of EMRE, and show that its known MCU-activating function is mediated by the interaction of transmembrane helices from both proteins.
It has been shown that the propagation of the TRPV1 (show TRPV1 ELISA Kits)-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX (show SLC24A6 ELISA Kits) and MCU.
Regulation of mitochondrial Ca(2 (show CA2 ELISA Kits)+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis.
MCU downregulation hampered cell motility and invasiveness and reduced tumor growth, lymph node infiltration, and lung metastasis in triple-negative breast cancer xenografts. In MCU-silenced cells, production of mitochondrial reactive oxygen species (mROS) is blunted and expression of the hypoxia-inducible factor-1alpha (HIF-1alpha (show HIF1A ELISA Kits)) is reduced, suggesting a signaling role for mROS and HIF-1alpha (show HIF1A ELISA Kits), downstream of mitochon...
These data indicate that Ca(2 (show CA2 ELISA Kits)+) uptake via mitochondrial uniporter contributes to palmitic acid-induced apoptosis in mouse podocytes.
a possible role for tissue-specific stoichiometry between the Ca(2 (show CA2 ELISA Kits)+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated.
MCUR1 binds to MCU and EMRE and function as a scaffold factor.
MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.
Reveal a distinct functional role for Cys (show DNAJC5 ELISA Kits)-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity.
The m-AAA (show AAAS ELISA Kits) protease associated with neurodegeneration limits MCU activity in mitochondria.
Data show that the serine/threonine kinase (show CDK4 ELISA Kits) LKB1 (show STK11 ELISA Kits) regulates mitochondrial calcium uniporter (MCU)-expression, mitochondria-dependent Ca2 (show CA2 ELISA Kits)+ clearance, and thereby, presynaptic release properties.
the Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 (show CA3 ELISA Kits) and CA1 (show CA1 ELISA Kits) regions in the adult hippocampus.
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.
calcium uniporter protein, mitochondrial
, coiled-coil domain-containing protein 109A
, coiled-coil domain containing 109A