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anti-Human MGEA5 Antibodies:
anti-Mouse (Murine) MGEA5 Antibodies:
anti-Rat (Rattus) MGEA5 Antibodies:
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Tax (show CNTN2 Antibodies) interacts with the host OGT (show OGT Antibodies)/OGA complex and inhibits the activity of OGT (show OGT Antibodies)-bound OGA.
TGFBR3 (show TGFBR3 Antibodies) and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas.
Data suggest that the substrate specificity of O-GlcNAcase/OGA does not extend to proteins/peptides modified with S-GlcNAc (an analog of O-GlcNAc (show OGT Antibodies)); proteins modified with S-GlcNAc appear to be stable against O-GlcNAcase/OGA hydrolysis.
hOGA (show OAT Antibodies) forms an unusual arm-in-arm homodimer in which the catalytic domain of one monomer is covered by the stalk domain of the sister monomer to create a substrate-binding cleft.
OGA is physically associated with the known RNA polymerase II (pol II) pausing/elongation factors SPT5 (show SUPT5H Antibodies) and TRIM28-KAP1-TIF1beta (show TRIM28 Antibodies), and a purified OGA-SPT5 (show SUPT5H Antibodies)-TIF1beta (show TRIM28 Antibodies) complex has elongation properties.
the O-linked N-acetylglucosamine (O-GlcNAc (show OGT Antibodies)) processing enzymes, O-GlcNAc (show OGT Antibodies)-transferase (OGT (show OGT Antibodies)) and O-GlcNAcase (OGA), interact with the (A)gamma-globin (show HBG1 Antibodies) promoter at the -566 GATA repressor (show ZBTB32 Antibodies) site
E2F1 (show E2F1 Antibodies) negatively regulates both Ogt (show OGT Antibodies) and Mgea5 expression in an Rb1 (show RB1 Antibodies) protein-dependent manner.
OGA overexpression in endothelial cells improves endothelial function and may have a beneficial effect on coronary vascular complications in diabetes.
Amino acid composition of splice variants, post-translational modifications, and stable associations with regulatory proteins influence subcellular distribution/substrate specificity of OGA and OGT (O-linked N-acetylglucosamine transferase (show OGT Antibodies)). [REVIEW]
This work identifies the first target of miR (show MLXIP Antibodies)-539 in the heart and the first miRNA that regulates OGA.
Furthermore, both Ogt (show OGT Antibodies) and Oga were required for the reversion from primed ESD (show ESD Antibodies)-EpiSCs to naive rESCs. These findings indicate that O-GlcNAcylation plays an important role in the survival of primed ESD (show ESD Antibodies)-EpiSCs and in their reversion to naive rESCs.
the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT (show OGT Antibodies)) and O-GlcNAcase (OGA), interact with the (A)gamma-globin (show HBG1 Antibodies) promoter at the -566 GATA repressor (show ZBTB32 Antibodies) site
Oga(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism
plays a critical role in placental vasculogenesis by modulating HIF-1alpha (show HIF1A Antibodies) stabilization
Conditional disruption of the O-GlcNAcase in mice leads to metabolic deregulation and semi-penetrant perinatal lethality.
The O-GlcNAcase active site resembles those of glycosidases which carry out the hydrolysis of GlcNAc linkages in a substrate-assisted acid-base manner.
Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development; these include Oga, Gfpt (glutamine-fructose-6-P aminotransferase), and Ogt (O-GlcNAc transferase).
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001
, bifunctional protein NCOAT
, hyaluronidase in meningioma
, meningioma-expressed antigen 5
, nuclear cytoplasmic O-GlcNAcase and acetyltransferase