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Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma
Data (including data from studies in knockout mice) suggest that Pck1 (show PCK1 ELISA Kits) in liver plays role in glucose homeostasis; here, Pck1 (show PCK1 ELISA Kits) deficiency (in knockout mice) can be successfully treated by re-expression of Pck1 (show PCK1 ELISA Kits) in liver, thus partially rescuing pups from fatal neonatal hypoglycemia. Pck1 (show PCK1 ELISA Kits) appears to play roles in metabolism in lung and skeletal muscle.
Lactate maintains/induces populations of postnatal neuronal progenitors/neural stem cells in a PEPCK-M-dependent manner
Silencing PCK1 (show PCK1 ELISA Kits) or inhibiting its enzymatic activity slows the growth of tumor-repopulating cells in vitro and impedes tumorigenesis in vivo.
Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines.
PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while approximately 10% re-expression of PEPCK-C normalized most parameters.
FAT/CD36 (show CD36 ELISA Kits) regulates PEPCK in adipose tissue and that this could be secondary to reductions in lipolysis.
PCB (show PC ELISA Kits) 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels.
the role of IL-6 (show IL6 ELISA Kits) signalling in adipose tissue during exercise
there are multiple cytokine pathways by which inflammation inhibits PEPCK expression in adipose tissue which could contribute to the increased mobilization of fatty acids during inflammation
ApoA-IV (show APOA4 ELISA Kits) colocalizes with NR4A1 (show NR4A1 ELISA Kits), which suppresses G6Pase (show G6PC ELISA Kits) and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.
Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine metabolism, increases anabolic metabolism and promotes mTORC1 activity.
Mitochondrial PCK2 regulates metabolic adaptation and enables glucose-independent tumor growth in various neoplasms.
When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase (show G6PC ELISA Kits)) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B cells.
PEPCK activity was elevated threefold in lung cancer samples over normal lungs and its activation mediates an adaptive response to glucose depletion in lung cancer.
Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.
expression of HCV nonstructural component NS5A in Huh7 or primary hepatocytes stimulated PEPCK gene expression and glucose output in HepG2 cells.
results reveal a novel link between glucose metabolism and the DNA damage signaling pathway and suggest a possible role for PEPCK and G6P in the DNA damage response
Transition to lactation does not alter expression of the mitochondrial form of PEPCK.
Concurrent binding and modifications of AUF1 (show HNRNPD ELISA Kits) and HuR (show ELAVL1 ELISA Kits) mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells.
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described.
phosphoenolpyruvate carboxykinase [GTP], mitochondrial
, mitochondrial phosphoenolpyruvate carboxykinase 2
, phosphoenolpyruvate carboxylase
, phosphoenolpyruvate carboxykinase
, Phosphoenolpyruvate carboxylase
, PEP carboxykinase
, phosphoenolpyruvate carboxykinase [ATP]
, phosphoenolpyruvate carboxykinase, cytosolic
, phosphoenolpyruvate carboxykinase, cytosolic [GTP]
, phosphopyruvate carboxylase