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human epidermal growth factor receptor (show EGFR Proteins) 2 (HER-2 (show ERBB2 Proteins)) levels, were correlated well with TSP50 (show PRSS50 Proteins)/p-Samd2 (show SARM1 Proteins)/3 and TSP50 (show PRSS50 Proteins)/p27 (show PAK2 Proteins) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (show PRSS50 Proteins)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
Furthermore, inhibition of COPS5 (show COPS5 Proteins) resulted in an elevation of Akt (show AKT1 Proteins) expression and sensitized SOC (show UBXN11 Proteins) cells to Akt (show AKT1 Proteins) inhibitor MK2206. Suppression of COPS5 (show COPS5 Proteins) and Akt (show AKT1 Proteins) offers a potential strategy for the treatment of SOC (show UBXN11 Proteins).
Loss of p27 (show PAK2 Proteins) associated with risk for endometrial carcinoma arising in the setting of obesity.
p53 (show TP53 Proteins) immunopositivity was more frequent in SCC (show CYP11A1 Proteins) (65%) than in VC (23%) (P=0.001). VC had lower p53 (show TP53 Proteins) as compared with well-differentiated SCC (show CYP11A1 Proteins) and SCC (show CYP11A1 Proteins) without lymph node metastasis. No significant difference was seen in pRb (show RB1 Proteins), p16, and p27 (show PAK2 Proteins) expression
The PSMD9 intronic SNPs rs74421874 (IVS3+nt460 G>A) and rs3825172 (IVS3+nt437 C>T) remain significantly associated with insomnia only when taking into account anxiety -and not depression- as covariate.
Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit (show PSMD14 Proteins) 9 (show ATP5G1 Proteins) (PSMD9), proteasome alpha type 7 (show PSMA7 Proteins) subunit (PSMA7 (show PSMA7 Proteins)) and PSMD13 (show PSMD13 Proteins) genes.
recurrence rate of p27 and/or PTEN-negative patients was higher than that of the positive ones,that should be followed up closely after treatment
The present study provided the first evidences that miR (show MLXIP Proteins)-1470 mediated lapatinib induced p27 (show PAK2 Proteins) upregulation by targeting c-jun (show JUN Proteins).
Staining intensities of cell cycle inhibitors p27 (show PAK2 Proteins) and p57 (show CDKN1C Proteins) significantly increased in all parts of preeclamptic placentas compared to control
PSMD9 expression predicts radiotherapy response in breast cancer.
These results therefore suggest that proteasomes, particularly p27 (show CDKN1B Proteins) subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene.
26S proteasome non-ATPase regulatory subunit 9
, 26S proteasome regulatory subunit p27
, homolog of rat Bridge 1
, proteasome 26S non-ATPase regulatory subunit 9
, transactivating protein Bridge-1
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
, proteasome 26S non-ATPase subunit 9
, PDZ domain-containing protein