Browse our Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) ELISA Kits

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Solute Carrier Family 30 (Zinc Transporter), Member 8 ELISA Kits (SLC30A8)
On www.antibodies-online.com are 12 Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) ELISA Kits from 8 different suppliers available. Additionally we are shipping Solute Carrier Family 30 (Zinc Transporter), Member 8 Antibodies (43) and Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (6) and many more products for this protein. A total of 64 Solute Carrier Family 30 (Zinc Transporter), Member 8 products are currently listed.
Synonyms:
C820002P14Rik, DKFZp469F0128, HMDPC, slc30a3, wu:fe49g03, ZnT-8, ZnT-10, ZNT8, ZNT10, ZRC1
list all ELISA KIts Gene Name GeneID UniProt
SLC30A8 239436 Q8BGG0
SLC30A8 299903 P0CE46
SLC30A8 169026 Q8IWU4

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Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) ELISA Kits by Reactivity

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More ELISA Kits for Solute Carrier Family 30 (Zinc Transporter), Member 8 Interaction Partners

Pig (Porcine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. slc30A8 colocalizes with ghrelin (show GHRL ELISA Kits) and motilin (show MLN ELISA Kits) in the gastrointestinal tract of pigs

  2. The absence of ZnT8 in glucagon (show GCG ELISA Kits)-producing cells in pig islets indicates that zinc homeostasis is mediated by a different cellular mechanism compared with human islet cells.

Mouse (Murine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. These data demonstrate that the function of ZnT8 in islets can be unmasked by removal of ZnT7 (show SLC30A7 ELISA Kits) and imply that ZnT8 may affect T2D susceptibility through actions in other tissues where it is expressed at low levels rather than through effects on pancreatic islet function.

  2. Our findings demonstrate that glucose homeostasis in the mouse improves as beta-cell ZnT8 activity increases, and remarkably, these changes track Zn(2+) rather than insulin (show INS ELISA Kits) release in vitro.

  3. Deletion of ZnT8 in a limited subset ( approximately 15%) of alpha-pancreatic cells is sufficient to increase glucagon (show GCG ELISA Kits) secretion at low glucose concentrations in vitro and in vivo and to improve the response to hypoglycemia.

  4. ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 (show RBMS1 ELISA Kits) plays a neuroprotective role against ischemic insult

  5. Data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology.

  6. Beta-cell Znt8 alone does not considerably aggravate weight gain and glucose intolerance during metabolic stress imposed by an high-fat high-calorie diet. Global loss of Znt8 is involved in diet-induced obesity and resulting insulin (show INS ELISA Kits) resistance.

  7. Downregulation of ZnT8 may be associated with impaired function of beta-cells in diabetes.

  8. Mutation of two Pdx-1 (show PDX1 ELISA Kits)-binding sites in enhancer A markedly reduces fusion gene expression suggesting that this factor contributes to Slc30a8 expression in beta-c

  9. Our data indicate that while, under the conditions studied, ZnT8 is absolutely essential for proper beta cell function, it is largely dispensable for alpha cell function.

  10. Results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.

Human Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. rs13266634/T SNP (SLC30A8) is a suggestive protective variant against gestational diabetes mellitus development.

  2. SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK (show EIF2AK3 ELISA Kits)-ATF4 (show ATF4 ELISA Kits) pathway.

  3. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 (show ATP2C1 ELISA Kits) in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 (show ATP2C1 ELISA Kits) or restoring the Mn-induced trafficking of ATP2C1 (show ATP2C1 ELISA Kits) can reduce Mn accumulation, providing a possible target for treating HMDPC.

  4. High Arg-325 variant in ZnT8 is associated with Risk for Type-2 Diabetes.

  5. The results provide a strong evidence for independent association between type 2 diabetes mellitus and SNPs for in TCF7L2 (show TCF7L2 ELISA Kits) and SLC30A8.

  6. this is the first study to report a significant association between the R325W C-allele of SLC30A8 and increased risk of developing gestational diabetes mellitus. All of the autoantibody positive women with GDM who developed postpartum type 1 diabetes were positive for autoantibodies against glutamic acid decarboxylase (show GAD ELISA Kits). Thus ZnT8A did not have any additional predictive value in postpartum development of type 1 diabetes.

  7. Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on type 2 diabetes mellitus in an African population when stratified by ethnicity under additive model even with a small number of studies.

  8. Results indicate a lack of association of the SLC30A8 SNPs with type 2 diabetes in Mexican American families.

  9. The hZnT8 R325W transgenic line had lower pancreatic [Zn(2+)]i and proinsulin (show INS ELISA Kits) and higher insulin (show INS ELISA Kits) and glucose tolerance compared with control littermates after 10 weeks of a high-fat diet in male mice. The converse was true for the hZnT8 WT transgenic line, and dietary Zn(2+) supplementation also induced glucose intolerance.

  10. Data indicate that gestational weight gain may modify SLC30A8 variant on long-term glycemic changes, highlighting the importance of gestational weight control in the prevention of postpartum hyperglycemia in women with GDM.

Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) Antigen Profile

Antigen Summary

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8)

  • solute carrier family 30 (zinc transporter), member 8 (slc30a8) Elisa Kit
  • solute carrier family 30 (zinc transporter), member 8 (SLC30A8) Elisa Kit
  • solute carrier family 30 member 8 (LOC100347644) Elisa Kit
  • solute carrier family 39 (zinc transporter), member 8 (SLC39A8) Elisa Kit
  • solute carrier family 30 (zinc transporter), member 8 (Slc30a8) Elisa Kit
  • solute carrier family 30, member 10 (SLC30A10) Elisa Kit
  • C820002P14Rik Elisa Kit
  • DKFZp469F0128 Elisa Kit
  • HMDPC Elisa Kit
  • slc30a3 Elisa Kit
  • wu:fe49g03 Elisa Kit
  • ZnT-8 Elisa Kit
  • ZnT-10 Elisa Kit
  • ZNT8 Elisa Kit
  • ZNT10 Elisa Kit
  • ZRC1 Elisa Kit

Protein level used designations for SLC30A8

ZnT8 , solute carrier family 30 (zinc transporter), member 8 , zinc transporter 8 , znT-8 , solute carrier family 30 member 8 , solute carrier family 30 (zinc transporter), member 3 , zinc transporter 8-like , solute carrier family 39 (zinc transporter), member 8 , zinc transporter ZIP8 , zinc transporter ZnT-8 , zinc transporter 10

GENE ID SPECIES
326926 Danio rerio
420285 Gallus gallus
464348 Pan troglodytes
482022 Canis lupus familiaris
496450 Xenopus (Silurana) tropicalis
701127 Macaca mulatta
100056898 Equus caballus
100155672 Sus scrofa
100461137 Pongo abelii
100595779 Nomascus leucogenys
100347644 Oryctolagus cuniculus
430411 Gallus gallus
461405 Pan troglodytes
478494 Canis lupus familiaris
508193 Bos taurus
100171966 Pongo abelii
100385303 Callithrix jacchus
239436 Mus musculus
299903 Rattus norvegicus
169026 Homo sapiens
496294 Xenopus laevis
55532 Homo sapiens
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