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Browse our Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (SLC30A8)

Full name:
Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (SLC30A8)
On www.antibodies-online.com are 6 Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) Proteins from 3 different suppliers available. Additionally we are shipping Solute Carrier Family 30 (Zinc Transporter), Member 8 Antibodies (43) and Solute Carrier Family 30 (Zinc Transporter), Member 8 Kits (10) and many more products for this protein. A total of 62 Solute Carrier Family 30 (Zinc Transporter), Member 8 products are currently listed.
Synonyms:
C820002P14Rik, DKFZp469F0128, HMDPC, slc30a3, wu:fe49g03, ZnT-8, ZnT-10, ZNT8, ZNT10, ZRC1
list all proteins Gene Name GeneID UniProt
Mouse SLC30A8 SLC30A8 239436 Q8BGG0
Rat SLC30A8 SLC30A8 299903 P0CE46
SLC30A8 169026 Q8IWU4

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Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (SLC30A8) by Origin

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More Proteins for Solute Carrier Family 30 (Zinc Transporter), Member 8 Interaction Partners

Pig (Porcine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. slc30A8 colocalizes with ghrelin (show GHRL Proteins) and motilin (show MLN Proteins) in the gastrointestinal tract of pigs

  2. The absence of ZnT8 in glucagon (show GCG Proteins)-producing cells in pig islets indicates that zinc homeostasis is mediated by a different cellular mechanism compared with human islet cells.

Mouse (Murine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. These data demonstrate that the function of ZnT8 in islets can be unmasked by removal of ZnT7 (show SLC30A7 Proteins) and imply that ZnT8 may affect T2D susceptibility through actions in other tissues where it is expressed at low levels rather than through effects on pancreatic islet function.

  2. Our findings demonstrate that glucose homeostasis in the mouse improves as beta-cell ZnT8 activity increases, and remarkably, these changes track Zn(2+) rather than insulin (show INS Proteins) release in vitro.

  3. Deletion of ZnT8 in a limited subset ( approximately 15%) of alpha-pancreatic cells is sufficient to increase glucagon (show GCG Proteins) secretion at low glucose concentrations in vitro and in vivo and to improve the response to hypoglycemia.

  4. ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 (show RBMS1 Proteins) plays a neuroprotective role against ischemic insult

  5. Data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology.

  6. Beta-cell Znt8 alone does not considerably aggravate weight gain and glucose intolerance during metabolic stress imposed by an high-fat high-calorie diet. Global loss of Znt8 is involved in diet-induced obesity and resulting insulin (show INS Proteins) resistance.

  7. Downregulation of ZnT8 may be associated with impaired function of beta-cells in diabetes.

  8. Mutation of two Pdx-1 (show PDX1 Proteins)-binding sites in enhancer A markedly reduces fusion gene expression suggesting that this factor contributes to Slc30a8 expression in beta-c

  9. Our data indicate that while, under the conditions studied, ZnT8 is absolutely essential for proper beta cell function, it is largely dispensable for alpha cell function.

  10. Results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.

Human Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. Results indicate a lack of association of the SLC30A8 SNPs with type 2 diabetes in Mexican American families.

  2. The hZnT8 R325W transgenic line had lower pancreatic [Zn(2+)]i and proinsulin (show INS Proteins) and higher insulin (show INS Proteins) and glucose tolerance compared with control littermates after 10 weeks of a high-fat diet in male mice. The converse was true for the hZnT8 WT transgenic line, and dietary Zn(2+) supplementation also induced glucose intolerance.

  3. Data indicate that gestational weight gain may modify SLC30A8 variant on long-term glycemic changes, highlighting the importance of gestational weight control in the prevention of postpartum hyperglycemia in women with GDM.

  4. results indicate that residues in the transmembrane and C-terminal domains together confer optimal manganese transport capability to SLC30A10 and suggest that the mechanism of ion coordination in the transmembrane domain of SLC30A10 may be substantially different from that in YiiP/other SLC30 proteins.

  5. We investigated the association of the polymorphisms rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes. The minor allele frequencies, for healthy and gestational diabetes, respectively, for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons showed no significant difference.

  6. Two miR (show MLXIP Proteins)-binding SNPs SLC30A8 rs2466293 and INSR (show INSR Proteins) rs1366600 increased Gestational diabetes mellitus susceptibility. Functional studies were required to confirm the underlying mechanism.

  7. we have successfully constructed a T1D phage display antibody library and identified two ZnT8-specific scFv clones, C27 and C22. These ZnT8-specific scFvs are potential agents in immunodiagnostic and immunotherapy of T1D

  8. allele was also associated with increased sway velocity (15%, P = .033; adjusted for age and sex) and reduced SLC30A10 expression

  9. Detection of ZnT8 antibodies in blood precedes detection of classical islet antibodies in children at risk of developing diabetes mellitus type 1.

  10. Studies indicate that people who have particular mutations in a gene called SLC30A8 (Solute carrier (show SERTAD2 Proteins) family 30, member 8) are 65% less likely to get diabetes.

Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) Protein Profile

Protein Summary

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8)

  • solute carrier family 30 (zinc transporter), member 8 (slc30a8)
  • solute carrier family 30 (zinc transporter), member 8 (SLC30A8)
  • solute carrier family 30 member 8 (LOC100347644)
  • solute carrier family 39 (zinc transporter), member 8 (SLC39A8)
  • solute carrier family 30 (zinc transporter), member 8 (Slc30a8)
  • solute carrier family 30, member 10 (SLC30A10)
  • C820002P14Rik protein
  • DKFZp469F0128 protein
  • HMDPC protein
  • slc30a3 protein
  • wu:fe49g03 protein
  • ZnT-8 protein
  • ZnT-10 protein
  • ZNT8 protein
  • ZNT10 protein
  • ZRC1 protein

Protein level used designations for SLC30A8

ZnT8 , solute carrier family 30 (zinc transporter), member 8 , zinc transporter 8 , znT-8 , solute carrier family 30 member 8 , solute carrier family 30 (zinc transporter), member 3 , zinc transporter 8-like , solute carrier family 39 (zinc transporter), member 8 , zinc transporter ZIP8 , zinc transporter ZnT-8 , zinc transporter 10

GENE ID SPECIES
326926 Danio rerio
420285 Gallus gallus
464348 Pan troglodytes
482022 Canis lupus familiaris
496450 Xenopus (Silurana) tropicalis
701127 Macaca mulatta
100056898 Equus caballus
100155672 Sus scrofa
100461137 Pongo abelii
100595779 Nomascus leucogenys
100347644 Oryctolagus cuniculus
430411 Gallus gallus
461405 Pan troglodytes
478494 Canis lupus familiaris
508193 Bos taurus
100171966 Pongo abelii
100385303 Callithrix jacchus
239436 Mus musculus
299903 Rattus norvegicus
169026 Homo sapiens
496294 Xenopus laevis
55532 Homo sapiens
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