Browse our TAR DNA Binding Protein Proteins (TARDBP)

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TAR DNA Binding Protein Proteins (TARDBP)
On www.antibodies-online.com are 14 TAR DNA Binding Protein (TARDBP) Proteins from 7 different suppliers available. Additionally we are shipping TAR DNA Binding Protein Antibodies (241) and TAR DNA Binding Protein Kits (32) and many more products for this protein. A total of 302 TAR DNA Binding Protein products are currently listed.
Synonyms:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
list all proteins Gene Name GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
Rat TARDBP TARDBP 298648  

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TAR DNA Binding Protein Proteins (TARDBP) by Origin

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Top referenced TAR DNA Binding Protein Proteins

  1. Human TARDBP Protein expressed in HEK-293 Cells - ABIN2733240 : Yang, Lin, Robertson, Wang: Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 (PubMed)
    Show all 3 references for 2733240

  2. Human TARDBP Protein expressed in Escherichia coli (E. coli) - ABIN1098222 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

More Proteins for TAR DNA Binding Protein Interaction Partners

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. removing the human orthologs of Hrb27c (DAZAP1 (show DAZAP1 Proteins)) in human neuronal cell lines can correct several pre-mRNA splicing events altered by TDP-43 depletion

  2. TDP-43 suppressed tau expression by promoting its mRNA instability through the UG repeats of its 3-UTR. The C-terminal region of TDP-43 was required for this function.The level of TDP-43, which is decreased in AD brains, was found to correlate negatively with the tau level in human brain.

  3. Amyotrophic lateral sclerosis mutations disrupt phase separation mediated by alpha-helical structure in the TDP-43 low-complexity C-terminal domain.

  4. we demonstrated cytoplasmic TDP-43 aggregate formation in neuronal and glial cells following adenoviral transduction of WT and CTF (show NFIA Proteins) TDP-43 under MG-132 treatment. These TDP-43 aggregates were phosphorylated and ubiquitinated and consisted of electron-dense granules.

  5. emphasize the importance of distinguishing cerebral age-related TDP-43 with sclerosis from late-onset frontotemporal lobar degeneration with TDP-43 pathology and from advanced Alzheimer disease with TDP-43 pathology

  6. Mutant and wild type human TDP-43 replacing the endogenous Drosophila gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.

  7. The study establishes a functional/physical partnership between FMRP (show FMR1 Proteins) and TDP-43 that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases.

  8. By silencing TDP-43, authors saw significant inhibition of cell proliferation and metastasis in A375 and WM451 cells. TDP-43 knockdown could suppress glucose transporter type-4 (GLUT4 (show SLC2A4 Proteins)) expression and reduce glucose uptake.

  9. The present study, based on 15 cases staged for pTDP-43 pathology, reports the finding that pathologically altered TDP-43 in Betz cells reacts differently than that in bulbar or spinal alpha-motoneurons. The major differences between the two types of histological profiles are discussed within the context of their possible consequences and implications for the potential further progression or spread of the pTDP-43 lesions.

  10. This study have shown that TDP-43-positive cytoplasmic inclusions were frequently found in the amygdala of pathologically and genetically confirmed cases of Frontotemporal Lobar Degeneration and Motor Neuron Disease.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. The findings of this study support a role for nuclear depletion of TDP-43 in the pathogenesis of AD and provide strong rationale for developing novel therapeutics to alleviate the depletion of TDP-43 and functional antemortem biomarkers associated with its nuclear loss.

  2. These results suggested that nuclear localization signal -tagged TDP25 (a carboxyl-terminal fragment of TDP-43) can change its structure to use ordered oligomeric but nontoxic state. Moreover, the structure of ordered oligomers as well as nuclear sequestration may be important in mediating cytotoxicity in ALS pathology.

  3. Mutatgion M337V in TDP-43 impaired the Nrf2 (show NFE2L2 Proteins)/ARE pathway by reducing the expression of MafK and JDP2 (show JDP2 Proteins) proteins.

  4. The suppression of TDP-43 mitochondrial localization abolishes WT and mutant TDP-43-induced mitochondrial dysfunction and neuronal loss, and improves phenotypes of transgenic mutant TDP-43 mice.

  5. we found a significant overlap in genes that undergo both RBM17 (show RBM17 Proteins)- and TDP-43-dependent cryptic splicing repression, many of which are associated with survival. We propose that repression of cryptic splicing by RBPs is critical for neuronal health and survival

  6. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  7. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  8. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  9. demonstrated that the levels of HSF1 (show HSF1 Proteins) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  10. The present study identified USP7 (show USP7 Proteins) and TDP-43 as the regulators of CRY1 (show CRY1 Proteins) and CRY2 (show CRY2 Proteins), underscoring the significance of the stability control process of CRY (show CRY2 Proteins) proteins for period determination in the mammalian circadian clockwork.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (show CNBP Proteins) tardbp and RNA binding protein fus (show FUS Proteins).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (show FUS Proteins) act in a pathogenic pathway that is independent of SOD1 (show SOD1 Proteins).

TAR DNA Binding Protein (TARDBP) Protein Profile

Protein Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP)
  • Tardbp protein (tardbp)
  • TAR DNA binding protein (tardbp)
  • TAR DNA binding protein (Tardbp)
  • TAR DNA-binding protein 43-like (LOC100621383)
  • 1190002A23Rik protein
  • ALS10 protein
  • C85084 protein
  • DKFZp459I2127 protein
  • tardbp protein
  • TDP-43 protein
  • Tdp43 protein
  • wu:fb77f02 protein
  • wu:fc52g10 protein

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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