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In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients.
circulating levels elevated and positively correlated with C-reactive protein (show CRP Proteins) in polycystic ovary syndrome
results show that activation of CRH (show CRH Proteins) receptors by CRH (show CRH Proteins) ligands stimulates VEGF-A (show VEGFA Proteins) expression in intestinal epithelial cells through the cAMP/CREB (show CREB1 Proteins) pathway
The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin (show SST Proteins) release to ensure the timely reduction of insulin (show INS Proteins) secretion upon normalization of plasma glucose.
The molecular modifications of urocortin 3[36-38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, could be further tested for possible clinical treatment of depression
Data suggest that UCN3 expression can serve as a late stage maturation/differentiation marker in beta-cells during pancreogenesis. [REVIEW]
SCP (show RAG1AP1 Proteins) inhibits a subpopulation of PVN neurons, especially OTergic magnocellular neurons, by enhancing the activity of GIRK channels via CRF-R2 (show CRHR2 Proteins)
study showed that Ucn2 (show UTS2 Proteins) and Ucn3 differentially regulate the LPS (show IRF6 Proteins)-induced TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins) expression and secretion in trophoblast explants acting through CRH-R2 (show CRHR2 Proteins). Ucn3 has an anti-inflammatory effect.
These data suggest a possible involvement of urocortin 2 (show UCN2 Proteins) and Ucn 3 in the mechanisms of endometriosis.
Confirm the anti-inflammatory function of VIP (show Vip Proteins), through the modulation of the expression of CRF (show CRH Proteins) system that impacts in a reduction of mediators with inflammatory/destructive functions.
findings collectively suggest that the MeA (show MEA1 Proteins) Ucn3-CRF-R2 (show CRHR2 Proteins) system modulates the ability of mice to cope with social challenges
Ucn3 KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
This study aims to investigate the cellular localization of CRF (show CRH Proteins) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Leptin (show LEP Proteins) regulates corticotropin-releasing factor (show CRH Proteins) and urocortin 2 (show UTS2 Proteins)/3 mRNA in hypothalamic neurons.
Urocortin 3 acting on CRFR2 (show CRHR2 Proteins) in skeletal muscle of Ucn3(+) mice results in a metabolic phenotype, with lean body composition and protection against diet-induced obesity and hyperglycaemia.
In this study, the intracerebroventricularly administered Ucn3 exerted an inhibitory effect on food intake, although the potency for decreasing food intake differed with the experimental conditions.
The results of this study suggested a novel role for UCN3 and CRH-R2 (show CRHR2 Proteins) related to the processing of social cues and to the establishment of social memories.
demonstrate the involvement of the hypothalamic neuropeptide Urocortin-3 in modulating septal and hypothalamic nuclei responsible for anxiety-like behaviors and metabolic functions, respectively.
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin 3
, prepro-urocortin 3
, ucn III
, urocortin III
, Urocortin II
, Urocortin III
, urocortin 3 (stresscopin)