Browse our anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Antibodies

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anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Antibodies (APBB1)
On www.antibodies-online.com are 118 Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Antibodies from 19 different suppliers available. Additionally we are shipping Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Proteins (8) and many more products for this protein. A total of 138 Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) products are currently listed.
Synonyms:
apbb1, FE65, MGC80654, MGC:9072, RIR
list all antibodies Gene Name GeneID UniProt
APBB1 11785 Q9QXJ1
APBB1 322 O00213
APBB1 29722 P46933

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Top referenced anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Antibodies

  1. Human Polyclonal APBB1 Primary Antibody for ELISA, WB - ABIN185689 : Hoe, Magill, Guenette, Fu, Vicini, Rebeck: FE65 interaction with the ApoE receptor ApoEr2. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Interaction Partners

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) interaction partners

  1. Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.

  2. results provide strong evidence that Fe65 plays a role in DNA damage response and cell viability by epigenomic regulation of specific transcriptional programs activated upon genotoxic stress.

  3. Findings show that amyloid precursor protein (show APP Antibodies)-binding proteins FE65 and FE65L1 (show APBB2 Antibodies) are essential for the maintenance of lens transparency.

  4. our data suggest that FE65 serves as a link between VLDLR (show VLDLR Antibodies) and APP (show APP Antibodies)

  5. FE65 small interfering RNA does not influence Rac1 expression or its activity, although it acts as an adaptor protein with several protein-interaction domains.

  6. Fe65 carries out different functions depending on its location in the regulation of Notch1 (show NOTCH1 Antibodies) signaling.

  7. a unique role for the 97 kDa isoform in controlling GnRH-1 (show GNRH1 Antibodies) neurogenesis that is not redundant with the 60 kDa isoform of FE65.

  8. Results confirm that megalin (show LRP2 Antibodies) interacts with APP (show APP Antibodies) and FE65, suggesting that these three proteins form a tripartite complex.

  9. Data show that the carboxyl-terminal half of FE65, which contains the PI2 (show SERPINB1 Antibodies) domain, failed to stabilize p53 (show TP53 Antibodies), suggesting that the amino-terminal half of the protein plays an important role in the stabilization of p53 (show TP53 Antibodies) in osmotically stressed cells.

  10. cell cycle progression by down-regulating thymidylate synthase (show TYMS Antibodies) expression

Human Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) interaction partners

  1. Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP (show APP Antibodies). Here, the subcellular localization was further investigated using TAP-tagged Fe65 constructs expressed in human neuroblastoma (show ARHGEF16 Antibodies) cells. Our results indicate that PTB2 (show PTBP1 Antibodies) rather than the WW domain (show DRP2 Antibodies) is important for the nuclear localization of Fe65.

  2. Fe65 Ser289 phosphorylation did not affect the transcriptional activity of the Fe65-APP (show APP Antibodies) complex, in contrast to the previously described Ser228 site.

  3. Our findings imply that APBB1 plays an important role in the maintenance of EMT (show ITK Antibodies)-associated CSC-like properties and gamma-radiation resistance via activation of IGF1Rbeta/AKT (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies) pathway in lung cancer cells, highlighting APBB1 as a potential target for therapeutic cancer treatment.

  4. Targeted enhancement of the signaling through the Fe65-cortactin (show CTTN Antibodies) pathway, by either HDAC6 (show HDAC6 Antibodies) inhibition or Tip60 (show KAT5 Antibodies) activation, may lead to the development of new therapeutic drugs that are effective for patients with metastatic breast cancers.

  5. Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.

  6. FE65 influences APP (show APP Antibodies) degradation via the proteasome, and phosphorylation of FE65 Ser (show SIGLEC1 Antibodies)(610) by SGK1 (show SGK1 Antibodies) regulates binding of FE65 to APP (show APP Antibodies), APP (show APP Antibodies) turnover and processing.

  7. A novel phosphorylation site was identified within Fe65 which mediates gene transcription.

  8. The SV2A (show SV2A Antibodies)/FE65 interaction might play a role in synaptic signal transduction.

  9. Data indicate that Fe65 is a positive estrogen receptor alpha (ERalpha (show ESR1 Antibodies)) transcriptional regulator.

  10. FE65 interactions with BLM and MCM proteins may contribute to the neuronal cell cycle re-entry observed in brains affected by Alzheimer's disease.

Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1)

  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1) antibody
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (apbb1) antibody
  • amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (APBB1IP) antibody
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1) antibody
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (Apbb1) antibody
  • apbb1 antibody
  • FE65 antibody
  • MGC80654 antibody
  • MGC:9072 antibody
  • RIR antibody

Protein level used designations for APBB1

amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) , amyloid beta A4 precursor protein-binding, family B, member 1 , amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein , amyloid beta A4 precursor protein-binding family B member 1-like , amyloid beta A4 precursor protein-binding family B member 1 , adaptor protein FE65a2 , stat-like protein , amyloid beta precursor protein-binding B1

GENE ID SPECIES
100069964 Equus caballus
446838 Xenopus laevis
466415 Pan troglodytes
100030868 Monodelphis domestica
100350673 Oryctolagus cuniculus
100354159 Oryctolagus cuniculus
100401543 Callithrix jacchus
100444276 Pongo abelii
100475168 Ailuropoda melanoleuca
11785 Mus musculus
322 Homo sapiens
29722 Rattus norvegicus
476833 Canis lupus familiaris
505096 Bos taurus
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