Browse our HIC1 Proteins (HIC1)

Full name:
Hypermethylated in Cancer 1 Proteins (HIC1)
On are 4 Hypermethylated in Cancer 1 (HIC1) Proteins from 3 different suppliers available. Additionally we are shipping HIC1 Antibodies (81) and HIC1 Kits (3) and many more products for this protein. A total of 94 HIC1 products are currently listed.
AA408311, HIC-1, HIC1, ZBTB29, zfHIC1, ZNF901
list all proteins Gene Name GeneID UniProt
HIC1 3090 Q14526
HIC1 15248 Q9R1Y5
Rat HIC1 HIC1 303310  

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HIC1 Proteins (HIC1) by Origin

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More Proteins for HIC1 Interaction Partners

Zebrafish Hypermethylated in Cancer 1 (HIC1) interaction partners

  1. These results suggest that up-regulation of MVP (show MVP Proteins) in multi-drug resistance (MDR) may involve chromatin remodeling.

Human Hypermethylated in Cancer 1 (HIC1) interaction partners

  1. Data show that expression of hypermethylated in cancer 1 protein (HIC1) is downregulated in uveal melanoma.

  2. HIC1 attenuates invasion and metastasis by inhibiting the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signalling pathway in human pancreatic ductal adenocarcinoma.

  3. Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma via EphA2 (show EPHA2 Proteins) signaling.

  4. The tumor-suppressive function of Hic1 in colon is related to its inhibitory action on proproliferative signaling mediated by the Tlr2 receptor present on tumor cells.

  5. Results demonstrated an important role of HIC1 for the normal progression of cell cycle, and could affect the homeostasis of p53 (show TP53 Proteins) as well as number of cell cycle-related genes, which may or may not be directly linked to p53 (show TP53 Proteins).

  6. We found that EVI1 (show MECOM Proteins) and HIC1 colocalize in the nucleus, and their interaction is mediated by the amino terminal zinc finger binding domain of EVI1 (show MECOM Proteins)

  7. HIC-1 expression was assessed on a tissue microarray containing 80 cases of breast cancer.

  8. Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 (show SIRT1 Proteins) might contribute to the carcinogenesis of pancreatic cancer.

  9. ectopic expression of HIC1 in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 (show LRP8 Proteins) and VLDLR (show VLDLR Proteins) genes, encoding two canonical tyrosine kinase (show TXK Proteins) receptors for Reelin (show RELN Proteins).

  10. HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2 (show LCN2 Proteins).

Mouse (Murine) Hypermethylated in Cancer 1 (HIC1) interaction partners

  1. identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb (show CBX2 Proteins)-like proteins.

  2. Data show that Hic1 expression is absent in polyps from DH mice, with concomitant increased expression of two transcriptional repression targets of Hic1, Sirt1 (show SIRT1 Proteins) and Sox9 (show SOX9 Proteins).

  3. A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1 (show EFNA1 Proteins).

  4. mice disrupted in the germ line for only one allele of Hic1 develop many different spontaneous malignant tumors, including a predominance of epithelial cancers in males and lymphomas and sarcomas in females

  5. In human osteosarcomas, hypermethylation of HIC1 is frequent only in tumors with p53 (show TP53 Proteins) mutation

  6. Inactivation of HIC1 results in upregulated SIRT1 (show SIRT1 Proteins) expression in normal or cancer cells; this deacetylates and inactivates p53 (show TP53 Proteins), allowing cells to bypass apoptosis and survive DNA damage.

  7. For the Hic-1 gene, but not p16, the p53 (show TP53 Proteins) gene might protect against aberrant methylation. The iNOS (show NOS2 Proteins) gene might not be involved in methylation of the Hic-1 gene, whereas the promoter region of p16 could be prone to methylation in MEFs lacking the iNOS (show NOS2 Proteins) gene.

HIC1 Protein Profile

Protein Summary

This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.

Alternative names and synonyms associated with HIC1

  • hypermethylated in cancer 1 (hic1)
  • hypermethylated in cancer 1 (HIC1)
  • hypermethylated in cancer 1 (Hic1)
  • AA408311 protein
  • HIC-1 protein
  • HIC1 protein
  • ZBTB29 protein
  • zfHIC1 protein
  • ZNF901 protein

Protein level used designations for HIC1

etID142640.25 , hypermethylated in cancer 1 protein , hypermethylated in cancer 1 , zinc finger and BTB domain-containing protein 29 , hypermethylated in cancer 1 protein-like , gammaFBP , gammaFBP-A , hic-1

436585 Danio rerio
750446 Pan troglodytes
3090 Homo sapiens
15248 Mus musculus
303310 Rattus norvegicus
491198 Canis lupus familiaris
786191 Bos taurus
396164 Gallus gallus
100525779 Sus scrofa
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