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anti-Human INO80 Antibodies:
anti-Rat (Rattus) INO80 Antibodies:
anti-Mouse (Murine) INO80 Antibodies:
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Cow (Bovine) Polyclonal INO80 Primary Antibody for ELISA - ABIN4226781
Yao, Song, Jin, Cai, Takahashi, Swanson, Washburn, Florens, Conaway, Cohen, Conaway: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. in Molecular cell 2008
our study defines a critical role of INO80 in promoting oncogenic transcription and NSCLC tumorigenesis, and reveals a potential treatment strategy for inhibiting the cancer transcription network by targeting the INO80 chromatin remodeling complex.
Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 (show YY1 Antibodies) in this process have been described.
The inositol hexaphosphate binding site is located within the C-terminal region of the Ino80 subunit.
the existence of both INO80 and YY1 (show YY1 Antibodies) is required for recruiting the INO80/YY1 (show YY1 Antibodies) complex to BCCIP (show BCCIP Antibodies) promoter region. Our findings strongly indicate that BCCIP (show BCCIP Antibodies) is a potential target gene of the INO80/YY1 (show YY1 Antibodies) complex.
The expression of Ino80, the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) ATPase (show DNAH8 Antibodies), is elevated in melanoma cells and patient melanomas compared with normal melanocytes and benign nevi.
Overexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors.
INO80 complex negatively regulates p21 (show CDKN1A Antibodies) expression in a p53 (show TP53 Antibodies)-mediated mechanism and is implicated in cell cycle phase G2/M arrest and abnormal chromosome stability.
INO80 is stabilized and targeted to replication forks by BAP1 (show RNF2 Antibodies) during normal DNA synthesis but downregulated in BAP1 (show RNF2 Antibodies) defective cancer cells
Mutations in INO80D is associated with translocation renal cell carcinoma (show MOK Antibodies).
The data indicate that under conditions of replication stress INO80 protects stalled forks from collapsing and allows their subsequent restart.
Mot1 (show BTAF1 Antibodies), Ino80 chromatin remodeling complex (Ino80C (show INO80C Antibodies)), and NC2 (show GTF2H5 Antibodies) co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
The loss of INO80 resulted in an arrest during meiosis associated with a failure to repair DNA damage during meiotic recombination
Ino80 represses Bmp4 (show BMP4 Antibodies) expression during embryonic stem cell differentiation.
INO80 is stabilized and targeted to replication forks by BAP1 (show BAP1 Antibodies) during normal DNA synthesis but downregulated in BAP1 (show BAP1 Antibodies) defective cancer cells
data reveal an essential role for INO80 in the expression of the pluripotency network and illustrate the coordination among chromatin remodeler, transcription factor, and histone-modifying enzyme in the regulation of the pluripotent state.
The mIno80 chromatin remodeling complex plays important roles in telomere replication, HDR (show GATA3 Antibodies)-mediated repair of dysfunctional telomeres, and maintenance of genome stability.
observations reveal a link between YY1 (show YY1 Antibodies) and INO80 and roles for both in homologous recombination-based repair, providing new insight into mechanisms that control the cellular response to genotoxic stress
The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. This complex binds DNA and is recruited by YY1 to activate certain genes.
DNA helicase INO80
, INO80 complex subunit A
, INO80 homolog
, homolog of yeast INO80
, putative DNA helicase INO80 complex homolog 1
, INO80 complex homolog 1
, yeast INO80-like protein