Browse our anti-SPRED1 (SPRED1) Antibodies

Full name:
anti-Sprouty-Related, EVH1 Domain Containing 1 Antibodies (SPRED1)
On www.antibodies-online.com are 108 Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) Antibodies from 14 different suppliers available. Additionally we are shipping SPRED1 Proteins (3) and many more products for this protein. A total of 118 SPRED1 products are currently listed.
Synonyms:
5730461F13Rik, AL024345, AW047647, fb14c08, fj51c03, hSpred1, NFLS, spred-1, wu:fb14c08, wu:fj51c03, Xspred1, Xtspred1, zgc:85707
list all antibodies Gene Name GeneID UniProt
SPRED1 114715 Q924S8
SPRED1 161742 Q7Z699
SPRED1 296072  

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anti-Mouse (Murine) SPRED1 Antibodies:

anti-Human SPRED1 Antibodies:

anti-Rat (Rattus) SPRED1 Antibodies:

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Top referenced anti-SPRED1 Antibodies

  1. Human Polyclonal SPRED1 Primary Antibody for EIA, IHC (p) - ABIN356945 : King, Straffon, DAbaco, Poon, I, Smith, Buchert, Corcoran, Hall, Callus, Sarcevic, Martin, Lock, Hovens: Distinct requirements for the Sprouty domain for functional activity of Spred proteins. in The Biochemical journal 2005 (PubMed)
    Show all 2 references for 356945

  2. Human Polyclonal SPRED1 Primary Antibody for IHC (p), WB - ABIN388229 : Brems, Chmara, Sahbatou, Denayer, Taniguchi, Kato, Somers, Messiaen, De Schepper, Fryns, Cools, Marynen, Thomas, Yoshimura, Legius: Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. in Nature genetics 2007 (PubMed)
    Show all 2 references for 388229

  3. Human Polyclonal SPRED1 Primary Antibody for FACS, WB - ABIN650630 : Yoshida, Hisamoto, Akiba, Koga, Nakamura, Tokunaga, Hanada, Kumemura, Maeyama, Harada, Ogata, Yano, Kojiro, Ueno, Yoshimura, Sata: Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. in Oncogene 2006 (PubMed)
    Show all 2 references for 650630

  4. Human Polyclonal SPRED1 Primary Antibody for ICC, IF - ABIN4355739 : Baras, Gandhi, Munari, Faraj, Shultz, Marchionni, Schoenberg, Hahn, Hoque, Hoque, Berman, Bivalacqua, Netto: Identification and Validation of Protein Biomarkers of Response to Neoadjuvant Platinum Chemotherapy in Muscle Invasive Urothelial Carcinoma. in PLoS ONE 2015 (PubMed)

More Antibodies against SPRED1 Interaction Partners

Mouse (Murine) Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) interaction partners

  1. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  2. SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (show MAPK1 Antibodies) signaling pathway in pluripotent cells

  3. The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK (show EPHB2 Antibodies) pathway.

  4. Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).

  5. show that neurofibromin (show NF1 Antibodies), the NF1 (show NF1 Antibodies) gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function

  6. The results suggest that Spred1 negatively regulates mast cell activation, which is modulated by miR126.

  7. SPRED1 is a likely substrate of SHP2 (show PTPN11 Antibodies), whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK (show EPHB2 Antibodies) pathway.

  8. Data show that both SPRED1 and SPRED2 (show SPRED2 Antibodies) inhibit the ability of DYRK1A (show DYRK1A Antibodies) to phosphorylate its substrates.

  9. These data suggest that Spreds are key regulators of RhoA (show RHOA Antibodies)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.

  10. Spred-1 and Spred-2 (show SPRED2 Antibodies) were found to be expressed predominantly in brain

Human Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) interaction partners

  1. The EVH1 domain of Spred1 binds to the noncatalytic portion of the GAP-related domain of neurofibromin (show NF1 Antibodies).

  2. Results provide genetic evidence that miR (show MLXIP Antibodies)-126, through its target gene Spred-1, plays a critical role in the development of retinal vascular layers.

  3. In one case we identified a nonsense mutation c.46C>T (p.Arg16*) in exon 2 of SPRED1 gene, confirming diagnosis of Legius syndrome. This mutation was reported previously.

  4. PURA (show PURA Antibodies) may be a potential target of miR (show MLXIP Antibodies)-144 and observed downregulation of PURA (show PURA Antibodies) may be caused by increased expression of miR (show MLXIP Antibodies)-144. The other predicted target of miR (show MLXIP Antibodies)-144 SPRED1, was found to be downregulated in 69 per cent EC tissues as compared to matched distant non-malignant tissues.

  5. Data suggest SPRED1 EVH1 domain interacts with NF1 (show NF1 Antibodies) GRD domain [N-term. 16AA/C-term. 20AA of GTPase-activating protein (show RASA1 Antibodies)-related domain]; SPRED1 EVH1 and NF1 (show NF1 Antibodies) GRD mutations observed in Legius syndrome reduce binding affinity between EVH1/GRD domains.

  6. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  7. SPRED1 decreased expression correlated with genetic features of AML (show RUNX1 Antibodies). Our study reveals a new mechanism which contributes to deregulate RAS MAPK (show MAPK1 Antibodies) pathway in the vast majority of paediatric AMLs

  8. Antisense-mediated knockdown (anti-miR (show MLXIP Antibodies)) revealed that miR (show MLXIP Antibodies)-206/21 coordinately promote RAS-ERK (show EPHB2 Antibodies) signaling and the corresponding cell phenotypes by inhibiting translation of the pathway suppressors RASA1 (show RASA1 Antibodies) and SPRED1.

  9. SPRED1 seems to play an important role in recruiting neurofibromin (show NF1 Antibodies) to the plasma membrane. (Review)

  10. Older age and deletions of IKZF1 (show IKZF1 Antibodies) and SPRED1 were also associated with poor overall survival of pediatric B-cell precursor acute lymphoblastic leukemia.

SPRED1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Alternative names and synonyms associated with SPRED1

  • sprouty-related, EVH1 domain containing 1 (spred1) antibody
  • sprouty-related, EVH1 domain containing 1 (SPRED1) antibody
  • SPRED1 (Bm1_51610) antibody
  • sprouty protein with EVH-1 domain 1, related sequence (Spred1) antibody
  • sprouty-related, EVH1 domain containing 1 (Spred1) antibody
  • 5730461F13Rik antibody
  • AL024345 antibody
  • AW047647 antibody
  • fb14c08 antibody
  • fj51c03 antibody
  • hSpred1 antibody
  • NFLS antibody
  • spred-1 antibody
  • wu:fb14c08 antibody
  • wu:fj51c03 antibody
  • Xspred1 antibody
  • Xtspred1 antibody
  • zgc:85707 antibody

Protein level used designations for SPRED1

sprouty-related, EVH1 domain-containing protein 1 , sprouty-related protein with EVH-1 domain 1 , sprouty-related, EVH1 domain containing 1 , spred-1 , sprouty-related, EVH1 domain-containing protein 1-like , SPRED1 , sprouty-related protein 1 with EVH-1 domain , suppressor of Ras/MAPK activation , sprouty protein with EVH-1 domain 1, related sequence

GENE ID SPECIES
406513 Danio rerio
423292 Gallus gallus
467654 Pan troglodytes
487485 Canis lupus familiaris
493399 Xenopus (Silurana) tropicalis
519882 Bos taurus
100057517 Equus caballus
100158360 Xenopus laevis
100512576 Sus scrofa
100563315 Anolis carolinensis
6105207 Brugia malayi
100351685 Oryctolagus cuniculus
100391851 Callithrix jacchus
100482511 Ailuropoda melanoleuca
100544962 Meleagris gallopavo
100583864 Nomascus leucogenys
114715 Mus musculus
161742 Homo sapiens
296072 Rattus norvegicus
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