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Mouse (Murine) Polyclonal CAD Primary Antibody for ELISA, ICC - ABIN4286809
Hara, Miyake, Arakawa, Kamidono, Hara: Over expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo. in The Journal of urology 2001
Show all 3 Pubmed References
Human Polyclonal CAD Primary Antibody for ICC, IF - ABIN253268
Morin, Fritsch, Mathieu, Gilbert, Guarmit, Firlej, Gallou-Kabani, Vieillefond, Delongchamps, Cabon: Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Show all 2 Pubmed References
Guinea Pig Polyclonal CAD Primary Antibody for ELISA, IHC - ABIN1584131
Zhdanov, Fahmi, Wang, Apostolov, Sokolov, Javadov, Basnakian: Regulation of Apoptotic Endonucleases by EndoG. in DNA and cell biology 2015
In this study, ChIP/chip datasets are analyzed using the corresponding PWMs for the well-studied TFs; CAUDAL, HUNCHBACK, KNIRPS and KRUPPEL, to determine the distribution of predicted binding sites. All four TFs are critical regulators of gene expression along the anterio-posterior axis in early Drosophila development
Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz (show NR5A1 Antibodies)) Caudal target gene.
Bicoid acts through a 63 nt response element in the caudal 3' untranslated region that includes a single miR (show MYLIP Antibodies)-2 target site. Four predicted Bicoid splice isoforms are capable of caudal repression; all require the microRNA target for repression.
Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region.
Bicoid recruits Bin3 to the caudal 3' UTR (show UTS2R Antibodies).
Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.
The caudal homeodomain protein activates Drosophila E2F (show E2F2 Antibodies) gene expression.
Transcriptional activation of the Drosophila caudal homeobox (show PRRX1 Antibodies) gene by the DRE (show SUFUH Antibodies)-binding factor (DREF (show ZBED1 Antibodies)).
In this study, we have identified the binding sites for bHLH-PAS (show PASK Antibodies) proteins, referred to as CNS midline element (CME), in the 5'-flanking region of the Drosophila caudal gene.
study shows that the intestinal homeobox (show PRRX1 Antibodies) gene Caudal regulates the commensal-gut (show GUSB Antibodies) mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide (show cAMP Antibodies) genes
Dff40 (show DFFB Antibodies) expression is upregulated in atherosclerotic plaque. Dff40 (show DFFB Antibodies) deficiency inhibited high-fat diet-induced atherosclerosis, as evidenced by decreased atherosclerotic plaques, inhibited inflammatory response, and macrophage apoptosis, as well as enhanced stability of plaques.
CAD functions as a necessary modulator of the hypertrophic response by regulating the mitogen-activated protein kinase (show MAPK1 Antibodies)-extracellular signal-regulated kinase 1/2 (show MAPK3 Antibodies) signaling pathway in the heart.
the highest order of chromatin compaction observed in the later steps of caspase (show CASP3 Antibodies)-dependent apoptosis relies on DFF40/CAD (show DFFB Antibodies)-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks
results show that caspase 3 (show CASP3 Antibodies)/CAD promotes cell differentiation by directly modifying the DNA/nuclear microenvironment, which enhances the expression of critical regulatory genes
Co-transfection of mouse DFF45 (show DFFA Antibodies)(-/-) fibroblasts with plasmids encoding human DFF40 (show DFFB Antibodies) and DFF45 (show DFFA Antibodies) reversed the apoptosis resistance normally observed in these cells
The thymus of DNase II(-/-)CAD(-/-) embryos contained many foci carrying undigested DNA and the cellularity was severely reduced due to a block in T cell development.
Interactions identified here between mouse liver histone H1 (show H1F0 Antibodies) carboxyl-terminal domain and DFF40/CAD (show DFFB Antibodies) target and activate linker DNA cleavage during the terminal stages of apoptosis.
The results suggest that CAD protein may be preferentially degraded by the ubiquitin-proteasome system in the absence of its inhibitor (ICAD (show DFFA Antibodies)) to maintain protein quality control.
A los of caspase-activated DNASE (show DFFB Antibodies) enhances tumorigenesis induced by a chemical carcinogen in a model of skin carcinogenesis in mice.
These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch/Vegf signaling during angiogenesis.
an essential role for CAD in facilitating proliferation and differentiation events in a tissue-specific manner
Detection of the CAD-ALK (show ALK Antibodies) gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK (show ALK Antibodies) kinase mutations that emerged during treatment with the ALK (show ALK Antibodies) inhibitor entrectinib
This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures.
Changes in glycosylation in caused by mutations in CAD.
These results establish CAD as a downstream effector of Rheb (show RHEB Antibodies) and suggest a possible role of Rheb (show RHEB Antibodies) in regulating de novo pyrimidine nucleotide synthesis
Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
The results obtained indicate that mLST8 (show MLST8 Antibodies) bridges between CAD and mTOR (show FRAP1 Antibodies), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (show FRAP1 Antibodies) pathway through the association with mLST8 (show MLST8 Antibodies)
preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD
findings show that in prostate tumor cells, CAD fosters androgen receptor (show AR Antibodies) translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse
the cad gene is regulated by a nonclassical ERalpha (show ESR1 Antibodies)/Sp1 (show PSG1 Antibodies)-mediated pathway.
Data show that PRMT5 can be found in association with hSWI/SNF complexes and is involved in regulating the expression of carbamoyl-phosphate synthase-aspartate carbamoyltransferase-dihydroorotase.
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
, CAD protein
, carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
, CAD protein-like
, CAD trifunctional protein
, multifunctional protein CAD
, carbamyl phosphatate synthetase 2
, CAD protein carbamylphosphate synthetase domain
, dihydrorotate synthase
, DNA fragmentation factor subunit beta
, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
, DNA fragmentation factor 40 kDa subunit
, DNA fragmentation factor, 40 kD, beta subunit
, DNase inhibited by DNA fragmentation factor
, caspase-activated DNase
, caspase-activated deoxyribonuclease