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Different dynamics and pathway of disulfide bonds reduction has been demonstrated for two human defensins, HD5 (show DEFA5 Proteins) and HBD-3.
In this study, the results showed genetically modified (GM) milk containing human beta-defensin-3 (HBD3) was easy to be digested in simulated gastric fluid, and it did not have adverse effects on general and gastrointestinal (GI) tract health compared to conventional milk.
this study shows that hBD3 amplifies the response to bacterial DNA in both mouse and human immune cells in a TLR9 (show TLR9 Proteins)-dependent manner
Direct interaction between SP-A or SAP01 and human BD-3 seemed to be responsible for the inhibitory effects on chemotaxis of mast cells.
Expression of hBD-1 (show DEFB1 Proteins), hBD-2 (show DEFB4 Proteins), hBD-3, and hBD-4 (show DEFB104A Proteins) in healthy and chronic periodontitis gingiva.
Per duplication of mRNA in whole blood, the risk of being a carrier increased by 93% for IL17A (show IL17A Proteins) and decreased by 35% for IFN-gamma (show IFNG Proteins). Independent of carriage and DEFB promotor haplotype, a 1-unit increase in IFN-gamma (show IFNG Proteins)/IL-17A (show IL17A Proteins) mRNA ratio led to a 24% increase in HBD3 mRNA in wounded skin. A low Th1 (show TH1L Proteins) to Th17 mRNA ratio increases the risk of colonization, with HBD3 being a potential link.
Analysis of TLR4 (show TLR4 Proteins) and HBD3 expression in epithelial cells demonstrates the key role of the innate immune factors in the pathogenesis of inflammatory and destructive periodontal lesions.
study indicated that the expression of HBD-2 (show DEFB4 Proteins) and HBD-3 mRNA and protein in lesions of cutaneous tuberculosis may be not consistent with that of tuberculids
epidermal growth factor receptor (EGFR (show EGFR Proteins))activation via phosphorylation of EGFR (show EGFR Proteins) via TAK1 (show MAP3K7 Proteins)-p38alpha (show MAPK14 Proteins) pathway, and subsequent internalization of EGFR (show EGFR Proteins) are functionally linked to the induction of hBD3 in gastric epithelial cells infected with H. pylori.
These results demonstrate that the gamma-core within HBD3 is the ancestral core of the full-length molecule and is a viable HDP (show HNRNPA1 Proteins) per se, since it is endowed with the most important biological features of HBD3
Thus, oral epithelial cells dominantly control IL-17R-dependent responses to oropharyngeal candidiasis through regulation of BD3 expression.
C/EBPbeta (show CEBPB Proteins) contributes to immunity to mucosal candidiasis during cortisone immunosuppression in a manner linked to beta-defensin 3 expression, but is apparently dispensable for the IL-17 (show IL17A Proteins)-dependent response.
Stress decreases mouse beta-defensin-3 expression in the esophagus of mice with diabetes.
visfatin (show NAMPT Proteins) enhances CAMP, hBD-2 (show DEFB4 Proteins), hBD-3, and S100A7 (show S100A7 Proteins) production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin.
this investigation revealed an indispensable role for BD3, BD4 (show DEFB4 Proteins), and CRAMP in defense against F. solani-induced keratitis
SP-A (show SFTPA1 Proteins) protects lung epithelium from tissue injury caused by BD3
Mouse beta-defensin 3 was strongly up-regulated in colonic epithelium of 15 (but not 5) week-old IL-2 (show IL2 Proteins)(-/-) mice and in dextran-sulfate-induced chronic (but not acute) colitis, but not in IL-2 (show IL2 Proteins)(+/-) 15-week-old mice.
Epithelial and mucosal tissues expressed bd3 and recombinant bd3 exhibits antifungal activity.
Murine beta-defensins BD2 (show DEFB4 Proteins) and BD3 together promote resistance against corneal infection by Pseudomonas aeruginosa.
Mycobacterial infection induces the expression of mBD3 (show MBD3 Proteins) and mBD4 (show MBD4 Proteins), and both might participate in the control of mycobacterial growth.
Expression of the bovine DEFB103 gene was surveyed in 27 tissues and transcript was most abundant in tissues with stratified squamous epithelium.
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.
, beta-defensin 3
, defensin, beta 103
, defensin, beta 3
, defensin-like protein
, beta defensin-2
, beta-defensin 4
, defensin beta 3
, beta defensin 3
, beta-defensin 103A
, defensin, beta 103B
, Beta-defensin 6
, bovine neutrophil beta-defensin 3
, defensin, beta 103A
, beta-defensin 103B
, beta-defensin 300