Browse our IKZF1 Proteins (IKZF1)

On www.antibodies-online.com are 3 IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) Proteins from 2 different suppliers available. Additionally we are shipping IKZF1 Antibodies (141) and IKZF1 Kits (8) and many more products for this protein. A total of 164 IKZF1 products are currently listed.
Synonyms:
5832432G11Rik, hik-1, hlk-1, hs.54452, ik1, Ikaros, ikzf1, LyF-1, lyf1, MGC108252, mKIAA4227, pro0758, RGD1562979, Zfpn1a1, Znfn1a1
list all proteins Gene Name GeneID UniProt
IKZF1 10320 Q13422
Rat IKZF1 IKZF1 305501  
IKZF1 22778  

IKZF1 Proteins (IKZF1) by Origin

More Proteins for IKZF1 Interaction Partners

Human IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. bioinformatics analysis indicated that both SNPs were located in a putative enhancer area in immune-related cell lines and tissues. A protein-protein interaction analysis found that IKZF1, together with GTF2I (an SS susceptibility gene newly identified through GWAS), could interact with histone deacetylase family proteins. In summary, this is the first study to report an association between IKZF1 and SS in Han Chinese

  2. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (show CISH Proteins)-element, which engages a THAP11/HCF-1 (show HCFC1 Proteins) complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 (show NFKB1 Proteins)

  3. Germline heterozygous IKZF1 mutations cause dysgammaglobulinemia, hematologic abnormalities (including B-cell defects), and autoimmune diseases

  4. Results suggest that the rs1456896 A allele is associated with protective susceptibility to lupus nephritis. However, this association did not seem to be implicated in the disease and histopathological severity of lupus nephritis in the current population, a northern Han Chinese cohort.

  5. elevated Ctnnd1 (show CTNND1 Proteins) expression contributes to maintenance of murine B-ALL cells with compromised Ikaros function.

  6. the presence of IKAROS deletion in acute lymphoblastic leukemia in Mexican Mestizos patients could represent a poor-prognosis marker and was probably related to therapy failure

  7. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros

  8. our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.

  9. ETV6 (show ETV6 Proteins) and IKZF1 are transcriptional regulators not just of ERG (show ERG Proteins), but also of a number of genes regulated by a densely interconnected network of seven transcription factors.

  10. results suggest that CRBN (show CRBN Proteins) binds to Ikaros via its N-terminal region and regulates transcriptional activities of Ikaros and its downstream target, enkephalin

Mouse (Murine) IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. ADAMTS10 (show ADAMTS10 Proteins) is identified as a potential functional integrator of the Ikaros-CtBP (show CTBP2 Proteins) chromatin remodeling network.

  2. this study shows that ablation of Ikzf1 in RORgammat+ group 3 innate lymphoid cells results in increased expansion and cytokine production, and protection against infection and colitis

  3. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros

  4. our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.

  5. These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.

  6. These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Proteins).

  7. Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.

  8. Ikaros is a fundamental regulator of PRC2 function in developing T cells.

  9. Ikaros/Ets1 binding has a role on Ikzf1 expression that is exerted at least through its promoter

  10. deletions on chromosomes 4 and 11 affecting Cdkn2a and Ikaros are a prominent feature of young adult irradiation-induced T-cell lymphoma.. tumors arising after irradiation suffer a second hit in Pten by mis (show AMH Proteins)-segregation or recombination

IKZF1 Protein Profile

Protein Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Alternative names and synonyms associated with IKZF1

  • IKAROS family zinc finger 1 (Ikaros) (IKZF1)
  • IKAROS family zinc finger 1 (Ikzf1)
  • IKAROS family zinc finger 1 (Ikaros) (ikzf1)
  • Ikaros homolog (ikaros)
  • 5832432G11Rik protein
  • hik-1 protein
  • hlk-1 protein
  • hs.54452 protein
  • ik1 protein
  • Ikaros protein
  • ikzf1 protein
  • LyF-1 protein
  • lyf1 protein
  • MGC108252 protein
  • mKIAA4227 protein
  • pro0758 protein
  • RGD1562979 protein
  • Zfpn1a1 protein
  • Znfn1a1 protein

Protein level used designations for IKZF1

CLL-associated antigen KW-6 , DNA-binding protein Ikaros , Ikaros (zinc finger protein) , ikaros family zinc finger protein 1 , lymphoid transcription factor LyF-1 , zinc finger protein, subfamily 1A, 1 (Ikaros) , Ikaros transcription factor , KAROS family zinc finger 1 (Ikaros) , IKAROS family zinc finger 1 (Ikaros) , DNA-binding protein Ikaros-like , zinc finger protein subfamily 1A, 1

GENE ID SPECIES
10320 Homo sapiens
305501 Rattus norvegicus
30177 Danio rerio
395974 Gallus gallus
483231 Canis lupus familiaris
541154 Bos taurus
548415 Xenopus (Silurana) tropicalis
744299 Pan troglodytes
100052437 Equus caballus
100356499 Oryctolagus cuniculus
100380614 Salmo salar
100403568 Callithrix jacchus
100436638 Pongo abelii
100475874 Ailuropoda melanoleuca
100601106 Nomascus leucogenys
22778 Mus musculus
100136762 Oncorhynchus mykiss
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