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This study provides the first evidence for the association of IKZF1 variants with diffuse large B-cell lymphoma outcome
showed that PTEN induced miR (show MLXIP Proteins)-26b expression by regulating the differential expression of Ikaros isoforms that are transcriptional regulators of miR (show MLXIP Proteins)-26b
These results show that the mechanism of action of lenalidomide in ABC (show ABCB6 Proteins)-DLBCL cells involves downregulation of SPIB (show SPIB Proteins) transcription by cereblon (show CRBN Proteins)-induced degradation of IKAROS.
IKZF1 and IKZF3 (show IKZF3 Proteins) expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients
Phosphorylation of Ikaros by CK2 (show CSNK2A1 Proteins) impairs Ikaros DNA-binding ability, as well as Ikaros ability to regulate gene expression and function as a tumor suppressor in leukemia. (Review)
High IKZF1 expression is associated with multiple myeloma.
bioinformatics analysis indicated that both SNPs were located in a putative enhancer area in immune-related cell lines and tissues. A protein-protein interaction analysis found that IKZF1, together with GTF2I (an SS susceptibility gene newly identified through GWAS), could interact with histone deacetylase family proteins. In summary, this is the first study to report an association between IKZF1 and SS in Han Chinese
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (show CISH Proteins)-element, which engages a THAP11/HCF-1 (show HCFC1 Proteins) complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 (show NFKB1 Proteins)
Germline heterozygous IKZF1 mutations cause dysgammaglobulinemia, hematologic abnormalities (including B-cell defects), and autoimmune diseases
Results suggest that the rs1456896 A allele is associated with protective susceptibility to lupus nephritis. However, this association did not seem to be implicated in the disease and histopathological severity of lupus nephritis in the current population, a northern Han Chinese cohort.
These data describe a novel regulatory mechanism through which STAT3 (show STAT3 Proteins) and the Ikaros zinc finger transcription factors Aiolos (show IKZF3 Proteins) and Ikaros cooperate to regulate Bcl-6 (show BCL6 Proteins) expression.
Ikaros is a transcriptional regulator required for maintaining levels of Foxo1 (show FOXO1 Proteins) gene expression in naive T-cells.
ADAMTS10 (show ADAMTS10 Proteins) is identified as a potential functional integrator of the Ikaros-CtBP (show CTBP2 Proteins) chromatin remodeling network.
this study shows that ablation of Ikzf1 in RORgammat+ group 3 innate lymphoid cells results in increased expansion and cytokine production, and protection against infection and colitis
Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros
our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.
These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.
These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Proteins).
Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.
Ikaros is a fundamental regulator of PRC2 function in developing T cells.
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
CLL-associated antigen KW-6
, DNA-binding protein Ikaros
, Ikaros (zinc finger protein)
, ikaros family zinc finger protein 1
, lymphoid transcription factor LyF-1
, zinc finger protein, subfamily 1A, 1 (Ikaros)
, Ikaros transcription factor
, KAROS family zinc finger 1 (Ikaros)
, IKAROS family zinc finger 1 (Ikaros)
, DNA-binding protein Ikaros-like
, zinc finger protein subfamily 1A, 1