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The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
RNF168, in complex with RAD6A (show ube2a ELISA Kits) or RAD6B (show UBE2B ELISA Kits), is activated in the DNA-damage-induced protein ubiquitination cascade.
Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (show TP53 ELISA Kits) in suppressing tumorigenesis.
We identified 85 overlapping deletions, of which six included the RPL35A (show RPL35A ELISA Kits) gene and all should be had Diamond-Blackfan anemia (DBA (show RPS19 ELISA Kits)).we sequenced the remaining RNF168 gene and examined her fibroblast culture for a DNA double strand break repair deficiency. These results were normal, indicating that the immunodeficiency is unlikely to result from a RNF168 deficiency.
Ubiquitin ligases RNF168, RNF169, and RAD18 (show RAD18 ELISA Kits) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (show TP53BP1 ELISA Kits) chromatin recruitment may be activated by RNF168 and blocked by RNF169 and RAD18 (show RAD18 ELISA Kits).
deregulated RNF168/53BP1 (show TP53BP1 ELISA Kits) pathway could promote tumorigenesis by selecting for a more robust, better stress-adapted cancer cell phenotype, through altered DNA repair, fueling genomic instability and tumor heterogeneity
Further mining of the UBE2U interactome uncovered its cognate E3 RNF17 (show RNF17 ELISA Kits) as a novel factor that, via the radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties (RIDDLE) syndrome protein RNF168, enforces DNA damage responses.
The association of RNF168 with PML (show PML ELISA Kits) NBs (show NBN ELISA Kits) resulted in increased ubiquitylation.
Results reveal an important role of USP7 (show USP7 ELISA Kits) in regulating ubiquitin-dependent signaling via stabilization of RNF168.
CK2 (show CSNK2A1 ELISA Kits)/WIP1 (show PPM1D ELISA Kits)-mediated modulation of LSD1 (show KDM1A ELISA Kits) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (show TP53BP1 ELISA Kits) to the DNA damage sites.
The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.
Finding that RNF8 (show RNF8 ELISA Kits) is less abundant than RNF168 identifies RNF8 (show RNF8 ELISA Kits) as a rate-limiting determinant of focal repair complex assembly
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
E3 ubiquitin-protein ligase RNF168
, ring fnger protein 168