Browse our RNF168 Proteins (RNF168)

Full name:
Ring Finger Protein 168 Proteins (RNF168)
On are 6 Ring Finger Protein 168 (RNF168) Proteins from 4 different suppliers available. Additionally we are shipping RNF168 Antibodies (58) and many more products for this protein. A total of 73 RNF168 products are currently listed.
3110001H15Rik, hRNF168
list all proteins Gene Name GeneID UniProt
RNF168 70238 Q80XJ2
RNF168 165918 Q8IYW5
RNF168 690043 B2RYR0

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RNF168 Proteins (RNF168) by Origin

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More Proteins for RNF168 Interaction Partners

Mouse (Murine) Ring Finger Protein 168 (RNF168) interaction partners

  1. RNF168, in complex with RAD6A (show ube2a Proteins) or RAD6B (show UBE2B Proteins), is activated in the DNA-damage-induced protein ubiquitination cascade.

  2. Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (show TP53 Proteins) in suppressing tumorigenesis.

Human Ring Finger Protein 168 (RNF168) interaction partners

  1. Ubiquitin ligases RNF168, RNF169 (show RNF169 Proteins), and RAD18 (show RAD18 Proteins) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (show TP53BP1 Proteins) chromatin recruitment may be activated by RNF168 and blocked by RNF169 (show RNF169 Proteins) and RAD18 (show RAD18 Proteins).

  2. deregulated RNF168/53BP1 (show TP53BP1 Proteins) pathway could promote tumorigenesis by selecting for a more robust, better stress-adapted cancer cell phenotype, through altered DNA repair, fueling genomic instability and tumor heterogeneity

  3. Further mining of the UBE2U (show UBE2U Proteins) interactome uncovered its cognate E3 RNF17 (show RNF17 Proteins) as a novel factor that, via the radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties (RIDDLE) syndrome protein RNF168, enforces DNA damage responses.

  4. The association of RNF168 with PML (show PML Proteins) NBs (show NBN Proteins) resulted in increased ubiquitylation.

  5. Results reveal an important role of USP7 (show USP7 Proteins) in regulating ubiquitin-dependent signaling via stabilization of RNF168.

  6. CK2 (show CSNK2A1 Proteins)/WIP1 (show PPM1D Proteins)-mediated modulation of LSD1 (show KDM1A Proteins) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (show TP53BP1 Proteins) to the DNA damage sites.

  7. The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.

  8. Finding that RNF8 (show RNF8 Proteins) is less abundant than RNF168 identifies RNF8 (show RNF8 Proteins) as a rate-limiting determinant of focal repair complex assembly

  9. Depletion of RNF8 (show RNF8 Proteins) or RNF168 blocks the degradation of diffusely localized nuclear 53BP1 (show TP53BP1 Proteins).

  10. The E3 ligase RNF168 promotes both H2A ubiquitylation and neddylation. RNF168 is itself a substrate for NEDD8, and neddylation of RNF168 is necessary for its E3 ubiquitin activity.

RNF168 Protein Profile

Protein Summary

This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.

Alternative names and synonyms associated with RNF168

  • ring finger protein 168 (Rnf168)
  • ring finger protein 168, E3 ubiquitin protein ligase (rnf168)
  • ring finger protein 168, E3 ubiquitin protein ligase (RNF168)
  • ring finger protein 168, E3 ubiquitin protein ligase (Rnf168)
  • 3110001H15Rik protein
  • hRNF168 protein

Protein level used designations for RNF168

E3 ubiquitin-protein ligase RNF168 , ring fnger protein 168

70238 Mus musculus
432198 Xenopus laevis
770166 Gallus gallus
165918 Homo sapiens
488029 Canis lupus familiaris
613812 Bos taurus
690043 Rattus norvegicus
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