Browse our Ring Finger Protein 8 Proteins (RNF8)

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Ring Finger Protein 8 Proteins (RNF8)
On are 7 Ring Finger Protein 8 (RNF8) Proteins from 3 different suppliers available. Additionally we are shipping Ring Finger Protein 8 Antibodies (97) and many more products for this protein. A total of 111 Ring Finger Protein 8 products are currently listed.
3830404E21Rik, AIP37, fc66f09, hRNF8, RNF8, wu:fc66f09, zgc:55936, zgc:77313
list all proteins Gene Name GeneID UniProt
RNF8 58230 Q8VC56
RNF8 9025 O76064
RNF8 361815 Q4KLN8

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Ring Finger Protein 8 Proteins (RNF8) by Origin

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Top referenced Ring Finger Protein 8 Proteins

  1. Human RNF8 Protein expressed in Wheat germ - ABIN1318397 : Delker, Zhou, Strikoudis, Stebbins, Papavasiliou: Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)
    Show all 2 references for 1318397

More Proteins for Ring Finger Protein 8 Interaction Partners

Mouse (Murine) Ring Finger Protein 8 (RNF8) interaction partners

  1. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  2. RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis. Neurons from RNF8(-/-) mice appear to be more susceptible to X-ray-induced DNA damage

  3. Altogether, the data in this study highlight the importance of p53 (show TP53 Proteins)-pathway activation upon loss of Rnf8, suggesting that Rnf8 and p53 (show TP53 Proteins) functionally interact to protect against genomic instability and tumorigenesis.

  4. The identification of RNF8 allows new insights into the integration of the control of p12 (show CDK2AP1 Proteins) degradation by different DNA damage signaling pathways.

  5. RNF8-dependent ubiquitination of histone H2A during meiosis establishes active epigenetic modifications, including dimethylation of H3K4 on the sex chromosomes

  6. A new mechanism of chromatin remodelling-assisted ubiquitylation was shown, which involves cooperation between CHD4 (show CHD4 Proteins) and RNF8 to create a local chromatin environment permissive to the assembly of checkpoint and repair machineries at DNA lesions.

  7. Rnf8 physically interacts with Tpp1 (show TPP1 Proteins) to generate Ubc13 (show UBE2N Proteins)-dependent Lys63 polyubiquitin (show UBB Proteins) chains that stabilize Tpp1 (show TPP1 Proteins) at telomeres.

  8. RNF8 and Chfr (show CHFR Proteins), function together to activate ATM (show ATM Proteins) and maintain genomic stability in vivo.

  9. 53BP1 (show TP53BP1 Proteins) protein binds to Rnf8, suggesting DNA damage involves RNF8 dependent ubiquitylation, which allows its accumulation at damaged chromatin.

  10. RNF8 deficint mice exhibit increased genomic instability and elevated risks for tumorigenesis indicating that Rnf8 is a novel tumor suppressor.

Human Ring Finger Protein 8 (RNF8) interaction partners

  1. The attenuated DNA damage localization of RNF8 resulting from INT6 (show EIF3E Proteins) depletion could be attributed to the defective retention of ATM (show ATM Proteins).

  2. In late S/G2 (show STRN3 Proteins) phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1 (show TNKS Proteins), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (show FAM175B Proteins)/BRCC36 (show BRCC3 Proteins)-containing deubiquitinase complex.

  3. Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage.

  4. High RNF8 expression is associated with bladder cancer.

  5. The interaction of MDC1 with RNF8, but not with ATM (show ATM Proteins) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Proteins).

  6. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 (show RNF168 Proteins) and USP11 to maintain the proper status of ubiquitylation gammaH2AX (show H2AFX Proteins) to repair double strand breaks.

  7. define a novel function for ATDC (show TRIM29 Proteins) in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC (show TRIM29 Proteins)

  8. Results indicate that RNF8 recruits and ubiquitinates many factors to repair DNA damage thereby conferring radioresistance to nasopharyngeal cancer cells.

  9. Significantly restored tolerance of RAD18 (show RAD18 Proteins)-/- and RNF8-/- cells to camptothecin and olaparib without affecting Rad51 (show RAD51 Proteins) focus formation.

  10. considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 and BRDT (show BRDT Proteins) genes in Chinese patients with non-obstructive azoospermia

Ring Finger Protein 8 (RNF8) Protein Profile

Protein Summary

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Ring Finger Protein 8 (RNF8)

  • ring finger protein 8 (RNF8)
  • ring finger protein 8 (Rnf8)
  • ring finger protein 8, E3 ubiquitin protein ligase (RNF8)
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8-a)
  • ring finger protein 8, E3 ubiquitin protein ligase (Rnf8)
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8)
  • 3830404E21Rik protein
  • AIP37 protein
  • fc66f09 protein
  • hRNF8 protein
  • RNF8 protein
  • wu:fc66f09 protein
  • zgc:55936 protein
  • zgc:77313 protein

Protein level used designations for Ring Finger Protein 8 Proteins (RNF8)

E3 ubiquitin-protein ligase RNF8 , ActA binding protein 2 , actA-interacting protein 37 , laXp180 , C3HC4-type zinc finger protein , UBC13/UEV-interacting ring finger protein , ring finger protein (C3HC4 type) 8 , E3 ubiquitin-protein ligase RNF8 A , E3 ubiquitin-protein ligase RNF8-A , RING finger protein 8 A , RING finger protein 8-A

515933 Bos taurus
58230 Mus musculus
9025 Homo sapiens
380076 Xenopus laevis
361815 Rattus norvegicus
481775 Canis lupus familiaris
100173982 Pongo abelii
404050 Danio rerio
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