Browse our Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins (TNFRSF4)

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Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins (TNFRSF4)
On www.antibodies-online.com are 54 Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Proteins from 11 different suppliers available. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 4 Antibodies (264) and Tumor Necrosis Factor Receptor Superfamily, Member 4 Kits (23) and many more products for this protein. A total of 351 Tumor Necrosis Factor Receptor Superfamily, Member 4 products are currently listed.
Synonyms:
ACT35, CD134, Ly-70, OX40, TNFRSF4, Txgp1, TXGP1L
list all proteins Gene Name GeneID UniProt
TNFRSF4 22163 P47741
TNFRSF4 7293 P43489
TNFRSF4 25572 P15725

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Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins (TNFRSF4) by Origin

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Top referenced Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins

  1. Human TNFRSF4 Protein expressed in HEK-293 Cells - ABIN2181573 : Arch, Thompson: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. in Molecular and cellular biology 1998 (PubMed)
    Show all 2 references for 2181573

  2. Mouse (Murine) TNFRSF4 Protein expressed in Human Cells - ABIN2008326 : Chen, McAdam, Buhlmann, Scott, Lupher, Greenfield, Baum, Fanslow, Calderhead, Freeman, Sharpe: Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. in Immunity 2000 (PubMed)
    Show all 2 references for 2008326

  3. Human TNFRSF4 Protein expressed in Human Cells - ABIN2002939 : Calderhead, Buhlmann, van den Eertwegh, Claassen, Noelle, Fell: Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. in Journal of immunology (Baltimore, Md. : 1950) 1993 (PubMed)
    Show all 2 references for 2002939

More Proteins for Tumor Necrosis Factor Receptor Superfamily, Member 4 Interaction Partners

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) interaction partners

  1. this study shows that OX40 links a costimulatory receptor to a repressive chromatin remodeling pathway, and that that OX40 stimulation inhibits IL-17 (show IL17A Proteins) and reduces experimental autoimmune encephalomyelitis

  2. IFNalphaR1 signaling promoted CXCL9 (show CXCL9 Proteins) and CXCL10 (show CXCL10 Proteins) synthesis, suggesting that these chemokines might be involved in the LPS (show TLR4 Proteins) and CD134 costimulation response.

  3. OX40 and ICOS (show ICOS Proteins) act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection

  4. OX40 regulates cardiac remodelling via the modulation of CD4 (show CD4 Proteins)(+) T-lymphocytes.

  5. bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4 (show CD4 Proteins)+ T cells to Th2 cells by ligation of OX40L (show TNFSF4 Proteins) and OX40 between BMMC-exosomes and CD4 (show CD4 Proteins)+ T cells and represents a novel mechanism of cell-to-cell communication

  6. Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes.

  7. The OX40-OX40 ligand (show TNFSF4 Proteins) interaction up-regulates intracellular levels of reactive oxygen species in atherogenesis.

  8. OX40 was highly expressed by intratumoral T cells, particularly those of the FoxP3 (show FOXP3 Proteins)(+) regulatory T-cell (Treg) lineage.

  9. OX40 and IL-7 (show IL7 Proteins) play synergistic, but distinct roles in the homeostatic proliferation of CD4 (show CD4 Proteins)(+) effector memory T cells

  10. OX40-OX40L (show TNFSF4 Proteins) interaction regulates the expression of NFATc1 (show NFATC1 Proteins), which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.

Human Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) interaction partners

  1. this study investigated whether CD134 is preferentially expressed on CD4 (show CD4 Proteins) T cells in drug-induced hypersensitivity syndrome .

  2. blocking of both OX-40L (show TNFSF4 Proteins) and 4-1BBL (show TNFSF9 Proteins) reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.

  3. Low OX40 expression is associated with colorectal cancer.

  4. OX40 and its ligand are co stimulators for T lymphocytes.

  5. These studies provide the first direct evidence that ligation of tumour necrosis factor (show TNF Proteins) superfamily members and their cognate receptors is important for the control of viral lytic replication.

  6. Malaria patients and Plasmodium-infected rodents exhibit enhanced expression of the co-stimulatory receptor OX40 on CD4 (show CD4 Proteins) T cells, which is abrogated following coordinate PD-1 (show PDCD1 Proteins) co-inhibitory pathways, which are also upregulated during malaria.

  7. Identified two key amino acid residues within CD134 that are required for its interaction with herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to CD134.

  8. TL1A (show TNFSF15 Proteins) increases expression of CD25 (show IL2RA Proteins), LFA-1 (show ITGAL Proteins), CD134 and CD154 (show CD40LG Proteins), and induces IL-22 (show IL22 Proteins) and GM-CSF (show CSF2 Proteins) production from effector CD4 (show CD4 Proteins) T-cells

  9. Data indicate that soluble OX40 and sOX40L plasma levels are increased in early rheumatoid arthritis patients.

  10. High expression of OX40 is associated with type 1 diabetes.

Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Alternative names and synonyms associated with Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4)

  • tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)
  • tumor necrosis factor receptor superfamily, member 4 (Tnfrsf4)
  • ACT35 protein
  • CD134 protein
  • Ly-70 protein
  • OX40 protein
  • TNFRSF4 protein
  • Txgp1 protein
  • TXGP1L protein

Protein level used designations for TNFRSF4

tumor necrosis factor receptor superfamily, member 4 , tumor necrosis factor receptor superfamily member 4 , OX40 antigen , OX40L receptor , tax-transcriptionally activated glycoprotein 1 , ACT35 antigen , ATC35 antigen , CD134 antigen , OX40 cell surface antigen , OX40 homologue , TAX transcriptionally-activated glycoprotein 1 receptor , lymphoid activation antigene ACT35 , tax-transcriptionally activated glycoprotein 1 receptor , MRC OX40 , Tax-transcriptionally activated glycoprotein 1 , tumor necrosis factor (ligand) superfamily member 4 , tumor necrosis factor superfamily, member 4

GENE ID SPECIES
457185 Pan troglodytes
489600 Canis lupus familiaris
528782 Bos taurus
699674 Macaca mulatta
22163 Mus musculus
493665 Felis catus
7293 Homo sapiens
25572 Rattus norvegicus
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