Browse our TRAF3IP2 Proteins (TRAF3IP2)

Full name:
TRAF3 Interacting Protein 2 Proteins (TRAF3IP2)
On are 3 TRAF3 Interacting Protein 2 (TRAF3IP2) Proteins from 2 different suppliers available. Additionally we are shipping TRAF3IP2 Antibodies (126) and many more products for this protein. A total of 142 TRAF3IP2 products are currently listed.
Act1, AI429613, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, MGC134034, PSORS13, RGD1304768, t3jam, TRAF3IP2
list all proteins Gene Name GeneID UniProt
Rat TRAF3IP2 TRAF3IP2 361857  
TRAF3IP2 10758 O43734
Mouse TRAF3IP2 TRAF3IP2 103213  

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TRAF3IP2 Proteins (TRAF3IP2) by Origin

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More Proteins for TRAF3IP2 Interaction Partners

Human TRAF3 Interacting Protein 2 (TRAF3IP2) interaction partners

  1. TRAF3IP2 SNP rs33980500 associated with no achievement of low disease activity nor remission at 6 months

  2. the first report to describe a non-adaptor function of Act1 by directly binding to the promoter region of IL-17A (show IL17A Proteins) responsive genes and directly regulate their transcription.

  3. ACT1 is an essential adaptor molecule of Il-17 (show IL17A Proteins)-induced expression of inflammation-related gene targets.

  4. Both the ACT-1 assay and the MAdCAM-1 (show MADCAM1 Proteins) assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested.

  5. A G/G genotype of rs766748 in IL-17F (show IL17F Proteins), and a C/C or C/A genotype of rs1883136 in TRAF3IP2.

  6. The suppressive effects of miR (show MLXIP Proteins)-30a were mediated by directly targeting Traf3ip2 mRNA

  7. TRAF3IP2 may play a causal role in aldosterone-induced adverse cardiac remodeling in vivo.

  8. Single nucleotide polymorphisms in RBPJ (show RBPJ Proteins), IL1R1 (show IL1RN Proteins), REV3L, TRAF3IP2, IRF1 (show IRF1 Proteins) and ICOS (show CTLA4 Proteins) showed association with rheumatoid arthritis in black South Africans.

  9. A variant (rs76228616 SNP) in TRAF3IP2 gene could be involved in susceptibility to Steven-Johnson Syndrome.

  10. identify Syk (show SYK Proteins) as an upstream signaling molecule in IL-17A (show IL17A Proteins)-induced Act1-TRAF6 (show TRAF6 Proteins) interaction in keratinocytes, and inhibition of Syk (show SYK Proteins) can attenuate CCL20 (show CCL20 Proteins) production

Mouse (Murine) TRAF3 Interacting Protein 2 (TRAF3IP2) interaction partners

  1. ameliorating myocardial damage by targeting TRAF3IP2 appears to be more effective to inhibiting its downstream signaling intermediates NF-kappaB (show NFKB1 Proteins) and JNK (show MAPK8 Proteins). Therefore, TRAF3IP2 could be a potential therapeutic target in ischemic heart disease

  2. these results demonstrate that overexpression of TRAF3IP2 in male mice is sufficient to induce myocardial hypertrophy, cardiac fibrosis, and contractile dysfunction.

  3. using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 (show SORL1 Proteins) exon 17, TRAF3IP2 exon 2, PPARG (show PPARG Proteins) exon 6) at single nucleotide resolution in the mouse liver

  4. TRAF3IP2 is a critical intermediate in IL-18 (show IL18 Proteins)-induced cardiac fibroblast migration and differentiation in vitro.

  5. Our results support the important role of Act1 in the regulation of self-reactive B cells and reveal how Act1 functions to prevent the production of autoantibodies.

  6. These results demonstrate for the first time that AOPPs induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent

  7. CIKS knockdown inhibited high glucose-induced IKKbeta (show IKBKB Proteins) and JNK (show MAPK8 Proteins) phosphorylation, p65 (show NFkBP65 Proteins) and c-Jun (show JUN Proteins) nuclear translocation, and NF-kappaB (show NFKB1 Proteins)- and AP-1 (show JUN Proteins)-dependent proinflammatory cytokine, chemokine (show CCL1 Proteins), and adhesion molecule (show NCAM1 Proteins) expression.

  8. The findings define a new role for the IKK-related kinases in suppressing IL-17-mediated NF-kappaB activation through TRAF6-dependent Act1 phosphorylation.

  9. Data show that deletion of the CC' loop from Act1 or IL-17RA (show IL17RA Proteins) abolished the interaction between both proteins.

  10. our findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness

TRAF3IP2 Protein Profile

Protein Summary

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.

Alternative names and synonyms associated with TRAF3IP2

  • Traf3 interacting protein 2 (Traf3ip2)
  • TRAF3 interacting protein 2 (TRAF3IP2)
  • adapter protein CIKS-like (LOC100467029)
  • adapter protein CIKS-like (LOC100480036)
  • adapter protein CIKS-like (LOC100490063)
  • TRAF3 interacting protein 2 (traf3ip3)
  • TRAF3 interacting protein 2 (LOC100226375)
  • TRAF3 interacting protein 2 (Traf3ip2)
  • Act1 protein
  • AI429613 protein
  • C6orf2 protein
  • C6orf4 protein
  • C6orf5 protein
  • C6orf6 protein
  • CIKS protein
  • MGC134034 protein
  • PSORS13 protein
  • RGD1304768 protein
  • t3jam protein
  • TRAF3IP2 protein

Protein level used designations for TRAF3IP2

adapter protein CIKS , TRAF3 interacting protein 2 , adapter protein CIKS-like , NFkB-activating protein ACT1 , connection to IKK and SAPK/JNK , nuclear factor NF-kappa-B activator 1

361857 Rattus norvegicus
100390719 Callithrix jacchus
100439347 Pongo abelii
100467029 Ailuropoda melanoleuca
100473939 Ailuropoda melanoleuca
100480036 Ailuropoda melanoleuca
100490063 Xenopus (Silurana) tropicalis
421752 Gallus gallus
494853 Xenopus laevis
549319 Xenopus (Silurana) tropicalis
616801 Bos taurus
697530 Macaca mulatta
741209 Pan troglodytes
100226375 Taeniopygia guttata
10758 Homo sapiens
103213 Mus musculus
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