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Subcellular localization of APC8 is regulated during male gametophyte development.
Results identified CDC23 as a miR (show MLXIP Proteins)-34c-regulated target that could be responsible for the miR (show MLXIP Proteins)-34c-induced cell cycle arrest.
CDC23 is a critical regulator of cell cycle (show C13orf15 Proteins) and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender.
Cdc20 (show CDC20 Proteins) requires APC3 and APC8 to bind and activate the APC (show APC Proteins)/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 (show ANAPC10 Proteins) is crucial for the destruction of cyclin B1 (show CCNB1 Proteins) and securin (show PTTG1 Proteins), but not cyclin A (show CCNA2 Proteins)
We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 (show CDC16 Proteins) and APC8/CDC23 which are known to be key function elements.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
cell division cycle protein 23
, cell division cycle protein 23 homolog
, cell division cycle 23 homolog (S. cerevisiae)
, CDC23 (cell division cycle 23, yeast, homolog)
, Cell division cycle protein 23 homolog
, cell division cycle protein 23 homolog-like
, anaphase-promoting complex subunit 8
, cyclosome subunit 8
, anaphase promoting complex subunit 8
, cell division cycle 23 homolog