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IL-20 and IL-24 (show IL24 Antibodies) increased the production of monocyte chemoattractant protein-1 (show CCL2 Antibodies) by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 (show DKK1 Antibodies) by SpA (show FASL Antibodies) fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 and IL-24 (show IL24 Antibodies) in spondyloarthritis
Data suggest that HGF (show HGF Antibodies), IL-20, and IL-22 (show IL22 Antibodies) in the serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before chemotherapy may be a prognostic of cancer progression.
The current study provides evidence that IL-20 directly targets and inhibits key inflammatory functions of neutrophils during infection with S. aureus.
Results found that IL-20 is more specifically associated with ER-positive breast cancer and is epigenetically regulated by estrogen via the specific recruitment of KMT2B (show MLL2 Antibodies) by ERalpha (show ESR1 Antibodies).
Coincident diabetes mellitus type 2 in either pulmonary or latent tuberculosis is characterized by decreased production of the IL-20 subfamily of cytokines.
IL-20 serum levels were increased in patients with active multiple myeloma compared to both healthy controls and responders to bortezomib-based treatment.IL-20 participate actively in the pathophysiology of multiple myeloma progression.
Data show reduced cytokines IL-10 (show IL10 Antibodies) and IL-19 (show IL19 Antibodies) expression, and enhanced IL-20 and il-1 beta (show IL1B Antibodies) expression in chronic recurrent multifocal osteomyelitis (CRMO) monocytes.
Overexpression of IL-20 was detected in the airway epithelium collected from patients with asthma.
Distribution of interleukin-10 (show IL10 Antibodies) family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different
IL-20 may play a patho-physiologic role in the Th2 immune response in human asthma and may be a potential biomarker of asthma severity.
our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22 (show IL22 Antibodies), and IL-24 (show IL24 Antibodies), might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
The authors conclude that IL-20 affects bone formation and downregulates osteoblastogenesis by modulating sclerostin (show SOST Antibodies), osterix (show SP7 Antibodies), RUNX2 (show RUNX2 Antibodies), and osteoprotegerin (show TNFRSF11B Antibodies) on osteoblasts.
Data show that interleukin 20 (IL-20) is expressed in type 2 diabetic db/db (show LEPR Antibodies) islets and contributes to inflammation.
IL-20 is primarily up regulated in psoriatic skin at the post-transcriptional level.
our results suggest that IL-20 plays pivotal roles in the tumor progression of breast cancer. IL-20 expression in breast cancer tissue is associated with a poor clinical outcome.
IL-20 is a proatherogenic cytokine that contributes to the progression of atherosclerosis.
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
novel effects of IL-20 on mesangial cells and its association with lupus nephritis.
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
, Interleukin 10 family protein
, cytokine Zcyto10
, four alpha helix cytokine
, four alpha helix cytokine ZCYTO10
, four helix bundle cytokine 10