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Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Depletion of IPO7 by IPO7 siRNA reduced nuclear accumulation of GLI1 (show GLI1 ELISA Kits). In addition, FOXM1 (show FOXM1 ELISA Kits) induced nuclear import of GLI1 (show GLI1 ELISA Kits) by promoting IPO7 expression.
Importin 7 as a soluble nuclear transport factor that is required for efficient import of the protein component of human telomerase.
Importin 7 contributes to the regulation of androgen receptor (show AR ELISA Kits) import by restraining import until androgen is detected in the cytoplasm.
imp7 is a part of an intrinsic pathway that promotes nuclear import of exogenous and endogenous DNA in mammalian cells.
Importin 7 (IPO7)is regulated positively by c-Myc (show MYC ELISA Kits) and negatively by p53 (show TP53 ELISA Kits).
essential for Egr-1 (show EGR1 ELISA Kits) nuclear translocation
Data show that ARHI could compete for Ran-importin binding and induce disruption of importin-binding to cargo proteins, including STAT3 (show STAT3 ELISA Kits).
role of IMP7 in nuclear transport of H1 histones
Nuclear import of HIV-1 intracellular reverse transcription is mediated by IPO7.
Down-regulation of importin 7 suppresses lung tumorigenesis via suppressing Akt (show AKT1 ELISA Kits) activity and inducing apoptosis
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
, RAN binding protein 7
, importin 7
, RAN-binding protein 7
, ran-binding protein 7