Browse our KPNA1 Proteins (KPNA1)

Full name:
Karyopherin alpha 1 (Importin alpha 5) Proteins (KPNA1)
On www.antibodies-online.com are 9 Karyopherin alpha 1 (Importin alpha 5) (KPNA1) Proteins from 6 different suppliers available. Additionally we are shipping KPNA1 Antibodies (97) and many more products for this protein. A total of 116 KPNA1 products are currently listed.
Synonyms:
AW494490, IPOA5, kpna1, mSRP1, NPI-1, NPI1, RCH2, si:ch211-161h7.7, SRP1
list all proteins Gene Name GeneID UniProt
KPNA1 16646 Q60960
KPNA1 288064  
KPNA1 3836 P52294

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KPNA1 Proteins (KPNA1) by Origin

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More Proteins for KPNA1 Interaction Partners

Mouse (Murine) Karyopherin alpha 1 (Importin alpha 5) (KPNA1) interaction partners

  1. mTOR (show FRAP1 Proteins) and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 (show STAT1 Proteins) by KPNA1, which are key modulators of STAT1 (show STAT1 Proteins) expression and apoptosis.

  2. KPNA1 knockdown increased myoblast proliferation.

  3. Importin alpha binding and the nuclear import of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin to 14-3-3 (show YWHAQ Proteins). These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 (show YWHAQ Proteins) binding.

  4. PTH1R (show PTH1R Proteins) forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta (show KPNB1 Proteins), and nuclear PTH1R (show PTH1R Proteins) is associated with the nucleoplasm

  5. Here, we show that the expression of importin-alpha subtypes is strictly regulated during neural differentiation of mouse embryonic stem (ES) cells, and that the switching of importin-alpha subtype expression is critical for neural differentiation.

  6. Absence of importin a5 during mouse development does not significantly interfere with neuronal differentiation and brain development.

Human Karyopherin alpha 1 (Importin alpha 5) (KPNA1) interaction partners

  1. Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (show STAT1 Proteins)/2 induced by IFN-beta (show IFNB1 Proteins), but p-STAT1 (show STAT1 Proteins)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 and induces degradation of cellular KPNA1 via caspase-3 (show CASP3 Proteins). [EV17 = Enterovirus 71]

  2. Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with TPX2 protein.

  3. BIG3 (show WDR5 Proteins) may block the KPNAs (KPNA1, KPNA5 (show KPNA5 Proteins), and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2 (show PHB2 Proteins).

  4. miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy

  5. Bel1 fragment with residues 215-223, which bears the NLS (show ALDH1A2 Proteins), interacts with KPNA1, KPNA6 (show KPNA6 Proteins), and KPNA7 (show KPNA6 Proteins).

  6. Results indicate CTNNBL1 (show CTNNBL1 Proteins) as a unique selective nuclear localization signals (NLSs)-binding protein with striking differences from karyopherin-alphas.

  7. This supports the notion that de novo mutations KPNA1 in are extremely rare in schizophrenia

  8. LRRC59 facilitates transport of cytosolic FGF1 through nuclear pores by interaction with Kpns and movement of LRRC59 along the ER and NE membranes

  9. mTOR (show FRAP1 Proteins) and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 (show STAT1 Proteins) by KPNA1, which are key modulators of STAT1 (show STAT1 Proteins) expression and apoptosis.

  10. the requirement for and the regulation of CAS (show CSE1L Proteins) in the functioning of the Vpr-Impalpha complex

Pig (Porcine) Karyopherin alpha 1 (Importin alpha 5) (KPNA1) interaction partners

  1. Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1 (show STAT1 Proteins)/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.

Cow (Bovine) Karyopherin alpha 1 (Importin alpha 5) (KPNA1) interaction partners

  1. Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7 (show IPO7 Proteins).

Xenopus laevis Karyopherin alpha 1 (Importin alpha 5) (KPNA1) interaction partners

  1. Data show that either an excess or a lack of importin alpha blocks nuclear envelope (NE) assembly in vitro, and that it also functions in NE assembly in conjunction with nuclear localization signal-containing partner proteins.

KPNA1 Protein Profile

Protein Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with KPNA1

  • importin alpha-1 subunit (EHI_124900)
  • karyopherin alpha 1 (importin alpha 5) (KPNA1)
  • karyopherin (importin) alpha 1 (Kpna1)
  • karyopherin alpha 1 (Kpna1)
  • karyopherin alpha 1 (importin alpha 5) (kpna1)
  • karyopherin alpha 7 (importin alpha 8) (kpna7)
  • AW494490 protein
  • IPOA5 protein
  • kpna1 protein
  • mSRP1 protein
  • NPI-1 protein
  • NPI1 protein
  • RCH2 protein
  • si:ch211-161h7.7 protein
  • SRP1 protein

Protein level used designations for KPNA1

importin alpha-1 subunit , Importin subunit alpha-1 , importin subunit alpha-5 , karyopherin subunit alpha-1 , NPI-1 , RAG cohort protein 2 , SRP1-beta , importin alpha-S1 , importin subunit alpha-1 , m-importin-alpha-S1 , nucleoprotein interactor 1 , importin alpha 5 , importin alpha-5 , karyopherin (importin) alpha 1 , karyopherin/importin alpha-1 , importin-alpha-S1 , recombination activating gene cohort 2 , importin alpha 1a

GENE ID SPECIES
6220066 Entamoeba histolytica HM-1:IMSS
100172964 Pongo abelii
16646 Mus musculus
288064 Rattus norvegicus
3836 Homo sapiens
478585 Canis lupus familiaris
397235 Sus scrofa
539679 Bos taurus
572542 Danio rerio
418271 Gallus gallus
398026 Xenopus laevis
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