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mTOR (show FRAP1 Proteins) and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 (show STAT1 Proteins) by KPNA1, which are key modulators of STAT1 (show STAT1 Proteins) expression and apoptosis.
KPNA1 knockdown increased myoblast proliferation.
Importin alpha binding and the nuclear import of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin to 14-3-3 (show YWHAQ Proteins). These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 (show YWHAQ Proteins) binding.
PTH1R (show PTH1R Proteins) forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta (show KPNB1 Proteins), and nuclear PTH1R (show PTH1R Proteins) is associated with the nucleoplasm
Here, we show that the expression of importin-alpha subtypes is strictly regulated during neural differentiation of mouse embryonic stem (ES) cells, and that the switching of importin-alpha subtype expression is critical for neural differentiation.
Absence of importin a5 during mouse development does not significantly interfere with neuronal differentiation and brain development.
Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (show STAT1 Proteins)/2 induced by IFN-beta (show IFNB1 Proteins), but p-STAT1 (show STAT1 Proteins)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 and induces degradation of cellular KPNA1 via caspase-3 (show CASP3 Proteins). [EV17 = Enterovirus 71]
Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with TPX2 protein.
BIG3 (show WDR5 Proteins) may block the KPNAs (KPNA1, KPNA5 (show KPNA5 Proteins), and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2 (show PHB2 Proteins).
miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
Bel1 fragment with residues 215-223, which bears the NLS (show ALDH1A2 Proteins), interacts with KPNA1, KPNA6 (show KPNA6 Proteins), and KPNA7 (show KPNA6 Proteins).
Results indicate CTNNBL1 (show CTNNBL1 Proteins) as a unique selective nuclear localization signals (NLSs)-binding protein with striking differences from karyopherin-alphas.
This supports the notion that de novo mutations KPNA1 in are extremely rare in schizophrenia
LRRC59 facilitates transport of cytosolic FGF1 through nuclear pores by interaction with Kpns and movement of LRRC59 along the ER and NE membranes
the requirement for and the regulation of CAS (show CSE1L Proteins) in the functioning of the Vpr-Impalpha complex
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1 (show STAT1 Proteins)/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.
Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7 (show IPO7 Proteins).
Data show that either an excess or a lack of importin alpha blocks nuclear envelope (NE) assembly in vitro, and that it also functions in NE assembly in conjunction with nuclear localization signal-containing partner proteins.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.
importin alpha-1 subunit
, Importin subunit alpha-1
, importin subunit alpha-5
, karyopherin subunit alpha-1
, RAG cohort protein 2
, importin alpha-S1
, importin subunit alpha-1
, nucleoprotein interactor 1
, importin alpha 5
, importin alpha-5
, karyopherin (importin) alpha 1
, karyopherin/importin alpha-1
, recombination activating gene cohort 2
, importin alpha 1a