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anti-Human SEC61B Antibodies:
anti-Mouse (Murine) SEC61B Antibodies:
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Human Polyclonal SEC61B Primary Antibody for EIA, WB - ABIN954705
Liao, Carpenter: Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor. in Cancer research 2009
Show all 2 references for 954705
Sec61beta overexpression increased tight junction modulation rates, in conjunction with enhanced delivery of claudin-4 (show CLDN4 Antibodies) from and to plasma membranes.
Sec61beta-KD cells also exhibited altered ATP7A (show ATP7A Antibodies) cellular distribution.
Sec61beta function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR (show EGFR Antibodies).
This indicates that EGF (show EGF Antibodies) receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 (show SEC61A1 Antibodies) translocon.
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Sec61 complex, beta subunit
, protein translocation complex beta
, protein transport protein SEC61 beta subunit
, protein transport protein Sec61 subunit beta
, protein translocation complex beta subunit