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Human Polyclonal TIMELESS Primary Antibody for ICC, IF - ABIN251537
Dheekollu, Lieberman: The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus. in Journal of virology 2011
Show all 2 Pubmed References
Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK (show CLOCK Antibodies)-CYC (show COX6C Antibodies) E-box binding, thus enhancing the removal of CLK (show CLOCK Antibodies)-CYC (show COX6C Antibodies) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK (show CLOCK Antibodies)-CYC (show COX6C Antibodies) from E-boxes
mir (show MYLIP Antibodies)-276a inhibits tim expression: Deleting the mir (show MYLIP Antibodies)-276a-binding site in the tim 3 (show HAVCR2 Antibodies)' UTR (show UTS2R Antibodies) causes elevated levels of TIM and approximately 50% arrhythmicity.
This is supported by attenuated interaction of IMPa1 (show IMPA1 Antibodies) with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER.
CULLIN-3 (show CUL3 Antibodies) is required for the circadian control of PERIOD and TIMELESS oscillations.
Timeless regulates phagocytosis of bacteria in Drosophila.
A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein.
This study demonstrated that timelss mutant affect TIMELESS and PERIOD post-trnaslational regulation and metabolism in cell nuclear.
A major transformation in the number and types of cells that express period and timeless takes place between embryonic and larval life.
The F-box protein (show FBXO30 Antibodies) slimb controls the levels of clock proteins period and timeless
CK2beta (show CSNK2B Antibodies) is localized within clock neurons and the clock proteins Period (Per) and Timeless (Tim) accumulate to abnormally high levels in the Andante mutant, suggesting a function for CK2 (show CSNK2A1 Antibodies)-dependent phosphorylation in the molecular oscillator
Stable ectopic overexpression of TIMELESS in nasopharyngeal carcinoma cell lines conferred resistance to cisplatin-induced apoptosis in vitro and in vivo, promoted an epithelial-to-mesenchymal transition phenotype, and activated the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway and downstream gene transcription.
the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin (show TIPIN Antibodies).
results provide the first evidence that TIM is required for the correct chromatin association of the CMG (show CASK Antibodies) complex to allow efficient DNA replication.
Our results show that TIMELESS overexpression correlates with pelvic lymph node metastasis, lymphovascular space involvement, as well as unfavorable OS and DFS (show FST Antibodies) in human cervical cancer. Therefore, TIMELESS expression may be a potential prognostic biomarker for cervical cancer patients
TIMELESS mutants unable to bind PARP1 (show PARP1 Antibodies). TIMELESS silencing significantly impairs DNA double-strand break repair.
Data reports the crystal structure of Timeless-PARP-1 (show PARP1 Antibodies) complex and provides evidence that Timeless is recruited to sites of DNA damage through PARP-1 (show PARP1 Antibodies) to mediate homologous recombination repair of DNA double-strand breaks.
overexpression of TIM exerts oncogenic function in human HCCs (show HCCS Antibodies), which is mediated via CHEK2 (show CHEK2 Antibodies) and EEF1A2 (show EEF1A2 Antibodies).
TIMELESS and RORA (show RORA Antibodies) genes may confer susceptibility to bipolar disorders and impact on circadian phenotypes
The results of this study suggest that the TIMELESS gene may be associated with the lithium prophylactic response in bipolar illness.
TIMELESS is frequently overexpressed in various types of tumor tissues, and elevated TIMELESS expression is associated with advanced tumor stage and poorer breast cancer prognosis.
The Phosphorylation of timeless protein by Hck (show HCK Antibodies) and Fyn (show FYN Antibodies) induced Tim ubiquitylation on K48 and subsequent degradation, while c-Src (show SRC Antibodies) and c-Yes (show YES1 Antibodies) led to K63-linked ubiquitylation and Tim accumulation within cells.
Data indicate that RNAi-mediated knockdown of TIMELESS (TIM) in NIH3T3 and U2OS cells shortens the period by 1 hour and diminishes DNA damage-dependent phase advancing.
mTIM promotes the nuclear localization of TIPIN (show TIPIN Antibodies), and TIPIN (show TIPIN Antibodies) is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes
TIM and Tipin (show TIPIN Antibodies) are functional orthologs of their replisome-associated yeast counterparts capable of coordinating
The tim-Tipin (show TIPIN Antibodies) dysfunction creates an indispensable reliance on the ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies) pathway for continued DNA synthesis.
human homolog is a circadian clock gene
, timeless homolog (Drosophila)
, timeless homolog
, protein timeless homolog-like
, protein timeless homolog
, Tof1 homolog
, timeless circadian clock 1
, timeless-like protein