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the association of TXNIP (thioredoxin-interacting protein) with NLRP3 (show NLRP3 ELISA Kits) induced by ROS (show ROS1 ELISA Kits) promoted NLRP3 (show NLRP3 ELISA Kits) inflammasome activation in senescent HUVEC endothelial cells
histone acetylation serves as a key regulator of glucose-induced increase in TXNIP gene expression
thioredoxin-interacting protein deficiency alleviates diabetic renal lipid accumulation through regulation of Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) pathway
High expression of TXNIP indicates a lower pathological grade of meningnioma, and is also associated with longer recurrence-free time.
All-trans retinoic acid plays a key role in inhibition of hepatic stellate cell activation via suppressing TXNIP expression, which reduces oxidative stress levels.
Study shows that TXNIP expression is down-regulated in new Multiple Sclerosis (MS) patients compared to controls and might be implicated in pathogenesis of the disease.
TXNIP Single nucleotide polymorphisms may individually and cumulatively affect CAD (show CAD ELISA Kits) risk through a possible mechanism for regulating TXNIP expression and gene-environment interactions.
Taken together, our results firstly reveal that TMAO induces inflammation and endothelial dysfunction via activating ROS (show ROS1 ELISA Kits)-TXNIP-NLRP3 (show NLRP3 ELISA Kits) inflammasome, suggest a likely mechanism for TMAO-dependent enhancement in atherosclerosis and cardiovascular risks.
results suggest that TXNIP is required early in the apoptotic-inducing pathway resulting from r-Moj-DM binding to the alphav integrin (show ITGAV ELISA Kits) subunit
Hypoxia suppresses thioredoxin binding protein-2 gene expression, which may ultimately alter placental development.
The molecular characterization of porcine TXNIP gene, is described.
single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain
Foam cell-released 4-hydroxnonenal activates PPARdelta (show PPARD ELISA Kits) in Vascular endothelial cells, leading to increased TXNIP expression and consequently to senescence.
TXNIP-NFYA (show NFYA ELISA Kits)-SREBP2 (show SREBF2 ELISA Kits)/miR (show MLXIP ELISA Kits)-33a-AMPKalpha (show GRK4 ELISA Kits)/CROT (show CROT ELISA Kits)/CPT1 (show CPT1A ELISA Kits)/HADHB (show HADHB ELISA Kits) pathway is conserved in mouse, rat, and human cardiomyocytes and regulates myocardial beta-oxidation.
results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 (show NLRP3 ELISA Kits) inflammasome pathway.
proteomic and functional analyses demonstrated that Txnip inhibits glucose transport through direct binding to glucose transporter 1 (GLUT1 (show SLC2A1 ELISA Kits)). An ex vivo analysis of perfused hearts further demonstrated that the enhanced functional reserve afforded by deletion of Txnip was associated with myocardial glucose utilization during beta-adrenergic stimulation.
Thrombin (show F2 ELISA Kits) activates reactive oxygen species (ROS (show ROS1 ELISA Kits))/thioredoxin (show TXN ELISA Kits) binding protein (TXNIP)/NLRP3 (show NLRP3 ELISA Kits) signaling in BV2 (show DNAH9 ELISA Kits) microglia cells, which may indicate a mechanism that pro-inflammatory and pro-apoptotic contributes to the development of intracerebral hemorrhage (ICH (show ACE ELISA Kits)).
TxNIP appears to be an important factor in FFA-induced ROS (show ROS1 ELISA Kits) generation and insulin (show INS ELISA Kits) resistance in skeletal muscle cells
Glucose exerts strong stimulatory effects on activation histone marks while having inhibitory effects on repression marks in the promoter of the TXNIP gene, and this was associated with a marked increase in expression of the proinflammatory gene in kidney.
Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS.
ITCH targets TXNIP for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (show TXN ELISA Kits) system.
regulates thioredoxin to play an important role in the preservation of cellular viability
thioredoxin interacting protein
, Thioredoxin-interacting protein
, thioredoxin binding protein 2
, thioredoxin-binding protein 2
, thioredoxin-interacting protein
, upregulated by 1,25-dihydroxyvitamin D-3
, vitamin D3 up-regulated protein 1
, hyperlipidemia 1
, thioredoxin binding protein-2