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ADIPOQ Protein (AA 18-247, full length) (His tag)

ADIPOQ Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 95 % WB, ELISA, PETIA
Catalog No. ABIN1046479
  • Target See all ADIPOQ Proteins
    ADIPOQ (Adiponectin (ADIPOQ))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 18-247, full length
    Origin
    • 24
    • 18
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Mouse
    Source
    • 27
    • 12
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This ADIPOQ protein is labelled with His tag.
    Application
    Western Blotting (WB), ELISA, Particle-Enhanced Turbidimetric Assay (PETIA)
    Sequence
    EDDVTTTEEL APALVPPPKG TCAGWMAGIP GHPGHNGTPG RDGRDGTPGE KGEKGDAGLL GPKGETGDVG MTGAEGPRGF PGTPGRKGEP GEAAYVYRSA FSVGLETRVT VPNVPIRFTK IFYNQQNHYD GSTGKFYCNI PGLYYFSYHI TVYMKDVKVS LFKKDKAVLF TYDQYQEKNV DQASGSVLLH LEVGDQVWLQ VYGDGDHNGL YADNVNDSTF TGFLLYHDTN
    Characteristics
    Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
    Purity
    95 %
    Top Product
    Discover our top product ADIPOQ Protein
  • Comment

    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole
    Storage
    -20 °C
  • Wang, Xu, Knight, Xu, Cooper: "Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19521-9, (2002) (PubMed).

    Yamauchi, Kamon, Waki, Terauchi, Kubota, Hara, Mori, Ide, Murakami, Tsuboyama-Kasaoka, Ezaki, Akanuma, Gavrilova, Vinson, Reitman, Kagechika, Shudo, Yoda, Nakano, Tobe, Nagai, Kimura, Tomita, Froguel et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. ..." in: Nature medicine, Vol. 7, Issue 8, pp. 941-6, (2001) (PubMed).

  • Target
    ADIPOQ (Adiponectin (ADIPOQ))
    Alternative Name
    Adiponectin (ADIPOQ Products)
    Synonyms
    ADP Protein, DCAF9 Protein, 6720489L24Rik Protein, 9330209L04Rik Protein, Adp Protein, Mamdc1 Protein, RNSVSP4U Protein, SVSIV1 Protein, Svp4 Protein, ACDC Protein, ACRP30 Protein, ADIPQTL1 Protein, ADPN Protein, APM-1 Protein, APM1 Protein, GBP28 Protein, apM-1 Protein, 30kDa Protein, APN Protein, Acdc Protein, Acrp30 Protein, Ad Protein, adipo Protein, apM1 Protein, ADN Protein, acrpl Protein, adipo-b Protein, adipoql Protein, zgc:153584 Protein, adipoq Protein, WD and tetratricopeptide repeats 1 Protein, MAM domain containing glycosylphosphatidylinositol anchor 2 Protein, seminal vesicle secretory protein 4 Protein, adiponectin, C1Q and collagen domain containing Protein, adiponectin, C1Q and collagen domain containing, b Protein, adiponectin, C1Q and collagen domain containing L homeolog Protein, WDTC1 Protein, Mdga2 Protein, Svs4 Protein, ADIPOQ Protein, Adipoq Protein, adipoqb Protein, adipoq.L Protein
    Background
    Synonyms: 30 kDa adipocyte complement-related protein,Adipocyte complement-related 30 kDa protein,ACRP30,Adipocyte, C1q and collagen domain-containing protein,Adipocyte-specific protein AdipoQ
    Molecular Weight
    29 kD
    UniProt
    Q60994
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