Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)

Details for Product No. ABIN1046691
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Protein Name
Synonyms Rantes, Scya5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, MuRantes
Protein Characteristics
AA 24-91, full length
(62), (25), (20), (5), (3), (2), (2), (2), (1), (1), (1)
Escherichia coli (E. coli)
(98), (9), (2), (2), (2)
Protein Type Recombinant
Purification tag / Conjugate
His tag
Pubmed 3 references available
Quantity 50 μg
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Catalog No. ABIN1046691
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Characteristics Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. Ref.3 Ref.8 Ref.10 Ref.11 Ref.12
Purity 90 %
Alternative Name C-C motif chemokine 5
Background Synonyms: EoCP,Eosinophil chemotactic cytokine,SIS-delta,Small-inducible cytokine A5,T cell-specific protein P228,TCP228,T-cell-specific protein RANTES
Molecular Weight 11.9 kD
UniProt P13501

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Format Liquid
Buffer 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole
Storage -20 °C
Product cited in: Capoulade-Métay, Ayouba, Kfutwah et al.: "A natural CCL5/RANTES variant antagonist for CCR1 and CCR3." in: Immunogenetics, Vol. 58, Issue 7, pp. 533-41, 2006 (PubMed).

Nomiyama, Fukuda, Iio et al.: "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 19, Issue 3, pp. 227-34, 1999 (PubMed).

Schall, Jongstra, Dyer et al.: "A human T cell-specific molecule is a member of a new gene family." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 3, pp. 1018-25, 1988 (PubMed).

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