Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)

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Protein Name
Protein Characteristics
AA 24-91, full length
(72), (30), (18), (5), (3), (3), (2), (2), (1), (1), (1), (1)
Escherichia coli (E. coli)
(111), (10), (3), (2), (2), (1)
Protein Type Recombinant
Purification tag / Conjugate
This CCL5 protein is labelled with His tag.
Pubmed 2 references available
Quantity 10 μg
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Availability Please contact our customer support.
Characteristics Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Purity 90 %
Alternative Name C-C motif chemokine 5 protein
Background Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. Ref.3 Ref.8 Ref.10 Ref.11 Ref.12
Molecular Weight 11.9 kD
UniProt P13501

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions For Research Use only
Format Lyophilized
Concentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handling Advice Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Storage -20 °C
Storage Comment Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Supplier Images
SDS-PAGE (SDS) image for Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag) (ABIN1046693) Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)
Background publications Capoulade-Métay, Ayouba, Kfutwah et al.: "A natural CCL5/RANTES variant antagonist for CCR1 and CCR3." in: Immunogenetics, Vol. 58, Issue 7, pp. 533-41, 2006 (PubMed).

Schall, Jongstra, Dyer et al.: "A human T cell-specific molecule is a member of a new gene family." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 3, pp. 1018-25, 1988 (PubMed).

Catalog No. ABIN1046693
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