Cathepsin D (CTSD) (AA 67-403), (partial) protein (GST tag)

Details for Product No. ABIN1046776
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Protein Name
Synonyms catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09, LOC398557, Cathd, CatD, LOC100136761, CTSD, DKFZp469J0315, DDBDRAFT_0205785, DDBDRAFT_0215012, DDB_0205785, DDB_0215012, CLN10, CPSD, CD
Protein Characteristics
AA 67-403, partial
Origin
Human
(38), (4), (4), (1), (1)
Source
Escherichia coli (E. coli)
(20), (6), (5), (5), (4), (2)
Protein Type Recombinant
Purification tag / Conjugate
GST tag
Application
SDS-PAGE (SDS), ELISA
Pubmed 3 references available
Quantity 200 μg
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Catalog No. ABIN1046776
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Sequence IPEVLKNYMD AQYYGEIGIG TPPQCFTVVF DTGSSNLWVP SIHCKLLDIA CWIHHKYNSD KSSTYVKNGT SFDIHYGSGS LSGYLSQDTV SVPCQSASSA SALGGVKVER QVFGEATKQP GITFIAAKFD GILGMAYPRI SVNNVLPVFD NLMQQKLVDQ NIFSFYLSRD PDAQPGGELM LGGTDSKYYK GSLSYLNVTR KAYWQVHLDQ VEVASGLTLC KEGCEAIVDT GTSLMVGPVD EVRELQKAIG AVPLIQGEYM IPCEKVSTLP AITLKLGGKG YKLSPEDYTL KVSQAGKTLC LSGFMGMDIP PPSGPLWILG DVFIGRYYTV FDRDNNR
Characteristics Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Purity 90 %
Alternative Name Cathepsin D
Molecular Weight 64.2 kD
UniProt P07339
Research Area Proteolysis / Ubiquitin, Extracellular Matrix, Proteases, Signaling
Comment

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Buffer PBS buffer, 20mM GSH
Storage -20 °C
Product cited in: Redecker, Heckendorf, Grosch et al.: "Molecular organization of the human cathepsin D gene." in: DNA and cell biology, Vol. 10, Issue 6, pp. 423-31, 1991 (PubMed).

Westley, May: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." in: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, 1987 (PubMed).

Faust, Kornfeld, Chirgwin: "Cloning and sequence analysis of cDNA for human cathepsin D." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 4910-4, 1985 (PubMed).

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