COL4A1 Protein (AA 30-167, partial) (GST tag)

Catalog No. ABIN1046837

Product Details

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Protein Type: Recombinant

Protein Characteristics: AA 30-167, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This COL4A1 protein is labelled with GST tag.

Application: SDS-PAGE (SDS), ELISA

Sequence: GCAGSGCGKC DCHGVKGQKG ERGLPGLQGV IGFPGMQGPE GPQGPPGQKG DTGEPGLPGT KGTRGPPGAS GYPGNPGLPG IPGQDGPPGP PGIPGCNGTK GERGPLGPPG LPGFAGNPGP PGLPGMKGDP GEILGHVP

Characteristics: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Ref.12 Ref.17 Ref.18 Ref.19 Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin

Purity: 90 %

Application Details

Comment:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS buffer, 20mM GSH

Storage: -20 °C

Target Details

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Alternative Name: Collagen alpha-1(IV) chain (COL4A1 Products)

Synonyms: col4a1 Protein, wu:fc02g11 Protein, HANAC Protein, ICH Protein, POREN1 Protein, arresten Protein, Bru Protein, Col4a-1 Protein, Del(8)44H Protein, Raw Protein, Svc Protein, collagen, type IV, alpha 5 (Alport syndrome) Protein, collagen type IV alpha 1 chain Protein, collagen, type IV, alpha 1 Protein, col4a5 Protein, COL4A1 Protein, Col4a1 Protein

Molecular Weight: 40.3 kD

UniProt: P02462

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding